GRPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRPR_HUMAN
• UniProt AC: P30550
• Protein Name: Gastrin-releasing peptide receptor
• Gene Name: GRPR
• Organism: Homo sapiens (Human).
• Sequence Length: 384
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Receptor for gastrin-releasing peptide (GRP). [PubMed: 1655761 Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory (By similarity]
• Protein Sequence: MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	N-linked_Glycosylation	VDHFMHCNISSHSAD CCEEECCCCCCCCCC	23.62	UniProtKB CARBOHYD
127	Phosphorylation	QLTSVGVSVFTLTAL EEECCCEEEEHHHHC	12.94	-
328	Phosphorylation	ALYLLSKSFRKQFNT HHHHHCHHHHHHCCH	27.23	29759185
335	Phosphorylation	SFRKQFNTQLLCCQP HHHHHCCHHEEEECC	23.14	29759185
339	S-palmitoylation	QFNTQLLCCQPGLII HCCHHEEEECCCEEE	2.49	-
348	Phosphorylation	QPGLIIRSHSTGRST CCCEEEEECCCCCCC	16.04	30108239
350	Phosphorylation	GLIIRSHSTGRSTTC CEEEEECCCCCCCCE	33.53	30108239
351	Phosphorylation	LIIRSHSTGRSTTCM EEEEECCCCCCCCEE	31.06	30108239
354	Phosphorylation	RSHSTGRSTTCMTSL EECCCCCCCCEECCC	29.43	30108239
355	Phosphorylation	SHSTGRSTTCMTSLK ECCCCCCCCEECCCC	23.74	30108239
356	Phosphorylation	HSTGRSTTCMTSLKS CCCCCCCCEECCCCC	11.09	30108239
359	Phosphorylation	GRSTTCMTSLKSTNP CCCCCEECCCCCCCC	32.81	30108239
360	Phosphorylation	RSTTCMTSLKSTNPS CCCCEECCCCCCCCC	13.60	30108239
362	Acetylation	TTCMTSLKSTNPSVA CCEECCCCCCCCCCE	55.81	7367235
363	Phosphorylation	TCMTSLKSTNPSVAT CEECCCCCCCCCCEE	38.42	28348404
364	Phosphorylation	CMTSLKSTNPSVATF EECCCCCCCCCCEEE	49.95	28348404
367	Phosphorylation	SLKSTNPSVATFSLI CCCCCCCCCEEEEEE	26.84	28348404
370	Phosphorylation	STNPSVATFSLINGN CCCCCCEEEEEECCC	16.17	28348404
372	Phosphorylation	NPSVATFSLINGNIC CCCCEEEEEECCCCC	24.80	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRPR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRPR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAR1_HUMAN	F2R	physical	28514442
AVR2B_HUMAN	ACVR2B	physical	28514442
CXG1_HUMAN	GJC1	physical	28514442
MRCKB_HUMAN	CDC42BPB	physical	28514442
UBP30_HUMAN	USP30	physical	28514442
CCHL_HUMAN	HCCS	physical	28514442
SC6A8_HUMAN	SLC6A8	physical	28514442
ASPH2_HUMAN	ASPHD2	physical	28514442
ARL8B_HUMAN	ARL8B	physical	28514442
RAB4A_HUMAN	RAB4A	physical	28514442
TAP1_HUMAN	TAP1	physical	28514442
MFSD5_HUMAN	MFSD5	physical	28514442
FADS1_HUMAN	FADS1	physical	28514442
MTG1_HUMAN	MTG1	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
S35G2_HUMAN	SLC35G2	physical	28514442
RAB3B_HUMAN	RAB3B	physical	28514442
DUSTY_HUMAN	DSTYK	physical	28514442
ADCK1_HUMAN	ADCK1	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
DPH6_HUMAN	DPH6	physical	28514442
F213A_HUMAN	FAM213A	physical	28514442
RAB32_HUMAN	RAB32	physical	28514442
MD2L2_HUMAN	MAD2L2	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
GNPAT_HUMAN	GNPAT	physical	28514442
PANX1_HUMAN	PANX1	physical	28514442
ABCB6_HUMAN	ABCB6	physical	28514442
TTK_HUMAN	TTK	physical	28514442
RAP1B_HUMAN	RAP1B	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
FND3A_HUMAN	FNDC3A	physical	28514442
RETR2_HUMAN	FAM134A	physical	28514442
ARF5_HUMAN	ARF5	physical	28514442
DHRS7_HUMAN	DHRS7	physical	28514442
CDS1_HUMAN	CDS1	physical	28514442
MET7B_HUMAN	METTL7B	physical	28514442
ARV1_HUMAN	ARV1	physical	28514442
MBLC2_HUMAN	MBLAC2	physical	28514442
S19A2_HUMAN	SLC19A2	physical	28514442
ARL5B_HUMAN	ARL5B	physical	28514442
LMBD2_HUMAN	LMBRD2	physical	28514442
BTAF1_HUMAN	BTAF1	physical	28514442
ATP7B_HUMAN	ATP7B	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
FACR2_HUMAN	FAR2	physical	28514442
MIPEP_HUMAN	MIPEP	physical	28514442
PTH2_HUMAN	PTRH2	physical	28514442
COX1_HUMAN	COX1	physical	28514442
GRP_HUMAN	GRP	physical	12021405

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.