GRP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRP_HUMAN
• UniProt AC: P07492
• Protein Name: Gastrin-releasing peptide
• Gene Name: GRP
• Organism: Homo sapiens (Human).
• Sequence Length: 148
• Subcellular Localization: Secreted . Cytoplasmic vesicle, secretory vesicle lumen .
• Protein Description: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity)..
• Protein Sequence: MRGRELPLVLLALVLCLAPRGRAVPLPAGGGTVLTKMYPRGNHWAVGHLMGKKSTGESSSVSERGSLKQQLREYIRWEEAARNLLGLIEAKENRNHQPPQPKALGNQQPSWDSEDSSNFKDVGSKGKVGRLSAPGSQREGRNPQLNQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	PLPAGGGTVLTKMYP CCCCCCCEEEEEEEE	18.67	-
50	Methionine amide	HWAVGHLMGKKSTGE CEEHHHHCCCCCCCC	6.49	-
50	Amidation	HWAVGHLMGKKSTGE CEEHHHHCCCCCCCC	6.49	3211139
50	Methylation	HWAVGHLMGKKSTGE CEEHHHHCCCCCCCC	6.49	3211139
52	Ubiquitination	AVGHLMGKKSTGESS EHHHHCCCCCCCCCC	29.59	-
53	Ubiquitination	VGHLMGKKSTGESSS HHHHCCCCCCCCCCC	47.74	-
68	Acetylation	VSERGSLKQQLREYI HHHHCCHHHHHHHHH	37.38	19814805
127	Acetylation	KDVGSKGKVGRLSAP CCCCCCCCEEEECCC	45.30	19820049

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GRP_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Amidation

"Posttranslational processing of endogenous and of baculovirus-expressed human gastrin-releasing peptide precursor.";
Lebacq-Verheyden A.-M., Kasprzyk P.G., Raum M.G.,van Wyke Coelingh K., Lebacq J.A., Battey J.F.;
Mol. Cell. Biol. 8:3129-3135(1988).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], AND AMIDATION AT MET-50.
PubMed: 3211139