APC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APC_RAT
• UniProt AC: P70478
• Protein Name: Adenomatous polyposis coli protein
• Gene Name: Apc
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 2842
• Subcellular Localization: Cell junction, adherens junction . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Cell projection, ruffle membrane . Cytoplasm . Cell membrane . Associated with the microtubule network at the growing distal tip of microtubules. Accumulate
• Protein Description: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity)..
• Protein Sequence: MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTELETEASNMKEVLKQLQGSIEDETMTSGQIDLLERLKEFNLDSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRAFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRAAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRVRQLLQSQAAEAERSSQSKHETASHEAERQLEGQGVAESNLATSGSGQSSAARVDHETAGVLSSSGTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMHGLTDDHYSVTLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQNLYGDYVFDASRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLSTYHSATENPGTSSKRGLQLSATAAQIAKVMEEVSALHTSQDDRSPASAAELHCVAEERTAARRSSASHTHPNTHNFAKSESSNRTCSMPYAKVEYKRSSNDSLNSVTSSDGYGKRGQMKPSVESYSEDDEGKFCSYGQYPADLAHKIHSANHMDDNGGELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQSRSQNTNFPVYSENTDDKHLKFQQHFGQQECVSPYRSRGTNGSETNRMGSSHAVNQNVNQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEEKHHVDQPIDYSLKYATDISSSQKPSFSFSKTPSVQGTKTEHNSPSSEAASAPSSNAKRQSQLHPSSAQRNGQTPKGTACKVPSINQETMQTYCVEDTPICFSRCSSLSSLSSAEDEIGCDQTTQEADSANTLQIAEIKENDVTRSAQDPASDVPAVSQSTRTKPSRLQASGLASESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLVFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIVSPSDLPDSPGQTMPPSRSKTPPPPPPPQPVQTKREVPKTKVPAAEQREGGPKQTAVSAAVQRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETEPEQPEESNENQDKEVEKPDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKLAQTASKLPPPVARKPSQLPVYKLLPSQSRLQAQKHVSFTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGDGVRASVQSGEFEKRDTIPTEGRSTDEAQRGKVSSIAIPDLDGSKAEEGDILAECINSALPKGRSHKPFRVKKIMDQVQQASMTSSGTNKNQIDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTEETFSDNKDSKKQSLKNNPKDLNDKLPDNEDRVRGGFTFDSPHHYAPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKGKESKDSEAKVTCHTEPSSSQQSARKAQASTKHPVNRGPSKPLLQEQPTFPQSSKDVPDRGAATDEKLQNFAIENTPVCFSRNSSLSSLSDVDQENNNNEETGPVRDAEPANAQGQPGKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLRECISSAMPKKRRPSRLKGEGEWQSPRKVGSVLAEDLTLDLKDIQRPESEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAAACLSRQASSDSDSILSLKSGVSLGSPFHLTPDQEEKPFTSHKGPRILKPGEKSTLEAKKIESENKGIKGGKKVYKSLITGKIRSNSEISSQMKQPLQTNMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGPVATTSPRGTKPAVKSELSPITRQTSHISGSNKGPSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNGISTPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLSKQTGLSKNASSIPRSESASKGLNQMNNSNGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYSDGRPSKRHDIARSHSESPSRLPVNRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSVPGPRQMKENQVPTKGTWRKIKESEISPTNTVSQTTSSGAASGAESKTLIYQMAPAVSRTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSISEKGNPSIKDSKDTQGKQSVGSGSPVQTVGLENRLNSFIQVEAPEQKGTETKAGQGSPAPVAETGETCMAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVGSSTKKRDSKTDSTESSGAQSPKRHSGSYLVTSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAASYDQL ------CCCCHHHHH	24.04	-
100	Phosphorylation	SYGSREGSVSSRSGE HCCCCCCCCCCCCCC	17.67	28689409
102	Phosphorylation	GSREGSVSSRSGECS CCCCCCCCCCCCCCC	23.02	28689409
103	Phosphorylation	SREGSVSSRSGECSP CCCCCCCCCCCCCCC	28.45	28689409
105	Phosphorylation	EGSVSSRSGECSPVP CCCCCCCCCCCCCCC	40.67	27097102
109	Phosphorylation	SSRSGECSPVPMGSF CCCCCCCCCCCCCCC	25.32	27097102
115	Phosphorylation	CSPVPMGSFPRRAFV CCCCCCCCCCCEEEC	26.31	28432305
128	Phosphorylation	FVNGSRESTGYLEEL ECCCCCCCCCHHHHH	26.48	28432305
129	Phosphorylation	VNGSRESTGYLEELE CCCCCCCCCHHHHHH	25.70	28432305
286	Phosphorylation	AARVDHETAGVLSSS CCCCCHHHCCEECCC	25.87	27097102
291	Phosphorylation	HETAGVLSSSGTHSA HHHCCEECCCCCCCC	21.76	27097102
292	Phosphorylation	ETAGVLSSSGTHSAP HHCCEECCCCCCCCC	28.73	27097102
293	Phosphorylation	TAGVLSSSGTHSAPR HCCEECCCCCCCCCH	44.31	27097102
295	Phosphorylation	GVLSSSGTHSAPRRL CEECCCCCCCCCHHH	18.01	27097102
297	Phosphorylation	LSSSGTHSAPRRLTS ECCCCCCCCCHHHHH	39.54	27097102
735	Phosphorylation	MANRPAKYKDANIMS HHCCCCCCCCCCCCC	19.06	25575281
742	Phosphorylation	YKDANIMSPGSSLPS CCCCCCCCCCCCCCC	23.47	27097102
745	Phosphorylation	ANIMSPGSSLPSLHV CCCCCCCCCCCCHHH	31.89	27097102
746	Phosphorylation	NIMSPGSSLPSLHVR CCCCCCCCCCCHHHH	50.65	27097102
749	Phosphorylation	SPGSSLPSLHVRKQK CCCCCCCCHHHHHHH	36.08	27097102
768	Phosphorylation	ELDAQHLSETFDNID HHHHHHHHHHHCCHH	32.25	28551015
770	Phosphorylation	DAQHLSETFDNIDNL HHHHHHHHHCCHHHC	32.67	28551015
778	Phosphorylation	FDNIDNLSPKASHRS HCCHHHCCHHHHHHH	30.52	23712012
809	Phosphorylation	SRHDDNRSDNFNTGN CCCCCCCCCCCCCCC	43.06	27097102
814	Phosphorylation	NRSDNFNTGNMTVLS CCCCCCCCCCCEEEE	26.29	27097102
818	Phosphorylation	NFNTGNMTVLSPYLN CCCCCCCEEEECCCC	23.46	27097102
821	Phosphorylation	TGNMTVLSPYLNTTV CCCCEEEECCCCCEE	13.73	27097102
823	Phosphorylation	NMTVLSPYLNTTVLP CCEEEECCCCCEECC	14.81	27097102
826	Phosphorylation	VLSPYLNTTVLPSSS EEECCCCCEECCCCC	18.71	27097102
827	Phosphorylation	LSPYLNTTVLPSSSS EECCCCCEECCCCCC	20.97	27097102
831	Phosphorylation	LNTTVLPSSSSSRGS CCCEECCCCCCCCCC	38.40	27097102
832	Phosphorylation	NTTVLPSSSSSRGSL CCEECCCCCCCCCCC	32.09	27097102
833	Phosphorylation	TTVLPSSSSSRGSLD CEECCCCCCCCCCCC	36.35	27097102
834	Phosphorylation	TVLPSSSSSRGSLDS EECCCCCCCCCCCCC	26.46	27097102
835	Phosphorylation	VLPSSSSSRGSLDSS ECCCCCCCCCCCCCC	42.48	27097102
879	Phosphorylation	SKRGLQLSATAAQIA CHHHHHHHHHHHHHH	15.60	22108457
893	Phosphorylation	AKVMEEVSALHTSQD HHHHHHHHHHCCCCC	28.52	25575281
897	Phosphorylation	EEVSALHTSQDDRSP HHHHHHCCCCCCCCC	29.00	25575281
898	Phosphorylation	EVSALHTSQDDRSPA HHHHHCCCCCCCCCC	22.36	25575281
903	Phosphorylation	HTSQDDRSPASAAEL CCCCCCCCCCCHHHH	31.64	25575281
906	Phosphorylation	QDDRSPASAAELHCV CCCCCCCCHHHHHHH	31.25	25575281
923	Phosphorylation	ERTAARRSSASHTHP HHHHHHHHHCCCCCC	25.38	28432305
924	Phosphorylation	RTAARRSSASHTHPN HHHHHHHHCCCCCCC	31.79	28432305
926	Phosphorylation	AARRSSASHTHPNTH HHHHHHCCCCCCCCC	30.76	28432305
928	Phosphorylation	RRSSASHTHPNTHNF HHHHCCCCCCCCCCC	36.21	25575281
957	Phosphorylation	AKVEYKRSSNDSLNS EEEEEECCCCCCCCC	29.37	27097102
958	Phosphorylation	KVEYKRSSNDSLNSV EEEEECCCCCCCCCC	49.00	27097102
961	Phosphorylation	YKRSSNDSLNSVTSS EECCCCCCCCCCCCC	33.43	27097102
964	Phosphorylation	SSNDSLNSVTSSDGY CCCCCCCCCCCCCCC	31.87	27097102
966	Phosphorylation	NDSLNSVTSSDGYGK CCCCCCCCCCCCCCC	23.49	25575281
967	Phosphorylation	DSLNSVTSSDGYGKR CCCCCCCCCCCCCCC	25.03	25575281
985	Phosphorylation	KPSVESYSEDDEGKF CCCCCCCCCCCCCCC	43.77	22673903
1029	Phosphorylation	PINYSLKYSDEQLNS CCEEEEECCHHHHHC	27.01	28432305
1030	Phosphorylation	INYSLKYSDEQLNSG CEEEEECCHHHHHCC	32.84	28432305
1036	Phosphorylation	YSDEQLNSGRQSPSQ CCHHHHHCCCCCCCC	43.90	27097102
1040	Phosphorylation	QLNSGRQSPSQNERW HHHCCCCCCCCCCCC	25.76	27097102
1042	Phosphorylation	NSGRQSPSQNERWAR HCCCCCCCCCCCCCC	51.38	27097102
1098	Phosphorylation	FGQQECVSPYRSRGT HCCCCCCCCCHHCCC	28.07	27097102
1100	Phosphorylation	QQECVSPYRSRGTNG CCCCCCCCHHCCCCC	17.45	23984901
1145	Phosphorylation	PTNYSERYSEEEQHE CCCHHHCCCHHHHCC	19.18	30181290
1146	Phosphorylation	TNYSERYSEEEQHEE CCHHHCCCHHHHCCC	44.76	30181290
1178	Phosphorylation	VDQPIDYSLKYATDI CCCCCCCEEEHHHCC	18.03	16641100
1210	Phosphorylation	GTKTEHNSPSSEAAS CCCCCCCCCCHHHHC	28.24	28432305
1212	Phosphorylation	KTEHNSPSSEAASAP CCCCCCCCHHHHCCC	40.40	28432305
1217	Phosphorylation	SPSSEAASAPSSNAK CCCHHHHCCCCCHHH	48.00	22276854
1221	Phosphorylation	EAASAPSSNAKRQSQ HHHCCCCCHHHHHHH	39.48	22276854
1324	Phosphorylation	ASDVPAVSQSTRTKP HHHCCCCCCCCCCCC	22.11	26022182
1352	Phosphorylation	RHKAVEFSSGAKSPS HHHHEECCCCCCCCC	17.85	28432305
1353	Phosphorylation	HKAVEFSSGAKSPSK HHHEECCCCCCCCCC	48.36	28432305
1357	Phosphorylation	EFSSGAKSPSKSGAQ ECCCCCCCCCCCCCC	33.59	27097102
1359	Phosphorylation	SSGAKSPSKSGAQTP CCCCCCCCCCCCCCC	46.69	27097102
1361	Phosphorylation	GAKSPSKSGAQTPKS CCCCCCCCCCCCCCC	43.64	28432305
1365	Phosphorylation	PSKSGAQTPKSPPEH CCCCCCCCCCCCCHH	31.95	27097102
1368	Phosphorylation	SGAQTPKSPPEHYVQ CCCCCCCCCCHHHCC	47.06	27097102
1373	Phosphorylation	PKSPPEHYVQETPLV CCCCCHHHCCCCCEE	11.36	28432305
1377	Phosphorylation	PEHYVQETPLVFSRC CHHHCCCCCEEEECC	12.58	28432305
1382	Phosphorylation	QETPLVFSRCTSVSS CCCCEEEECCCCCHH	20.97	29779826
1385	Phosphorylation	PLVFSRCTSVSSLDS CEEEECCCCCHHCCC	30.93	27097102
1386	Phosphorylation	LVFSRCTSVSSLDSF EEEECCCCCHHCCCC	24.51	27097102
1388	Phosphorylation	FSRCTSVSSLDSFES EECCCCCHHCCCCHH	25.58	27097102
1389	Phosphorylation	SRCTSVSSLDSFESR ECCCCCHHCCCCHHC	33.76	27097102
1392	Phosphorylation	TSVSSLDSFESRSIA CCCHHCCCCHHCHHH	35.89	27097102
1395	Phosphorylation	SSLDSFESRSIASSV HHCCCCHHCHHHHHC	29.35	27097102
1404	Phosphorylation	SIASSVQSEPCSGMV HHHHHCCCCCCCCCC	41.15	26022182
1416	Phosphorylation	GMVSGIVSPSDLPDS CCCCCCCCHHHCCCC	19.43	25575281
1418	Phosphorylation	VSGIVSPSDLPDSPG CCCCCCHHHCCCCCC	44.25	25575281
1423	Phosphorylation	SPSDLPDSPGQTMPP CHHHCCCCCCCCCCC	29.05	25575281
1427	Phosphorylation	LPDSPGQTMPPSRSK CCCCCCCCCCCCCCC	37.24	25575281
1431	Phosphorylation	PGQTMPPSRSKTPPP CCCCCCCCCCCCCCC	43.23	25575281
1433	Phosphorylation	QTMPPSRSKTPPPPP CCCCCCCCCCCCCCC	45.26	27097102
1435	Phosphorylation	MPPSRSKTPPPPPPP CCCCCCCCCCCCCCC	42.13	27097102
1536	Phosphorylation	ENDNGNETEPEQPEE CCCCCCCCCCCCCCC	61.92	27097102
1544	Phosphorylation	EPEQPEESNENQDKE CCCCCCCCCCCCCCC	48.02	27097102
1557	Phosphorylation	KEVEKPDSEKDLLDD CCCCCCCCHHCCCCC	55.89	29779826
1565	Phosphorylation	EKDLLDDSDDDDIEI HHCCCCCCCCCHHHH	42.48	22673903
1608	Phosphorylation	PPVARKPSQLPVYKL CCCCCCCCCCCHHHC	47.59	25403869
1650	Phosphorylation	EGTPINFSTATSLSD ECCCEECCCCCCHHH	16.79	28551015
1651	Phosphorylation	GTPINFSTATSLSDL CCCEECCCCCCHHHC	29.80	28551015
1653	Phosphorylation	PINFSTATSLSDLTI CEECCCCCCHHHCEE	30.23	28551015
1654	Phosphorylation	INFSTATSLSDLTIE EECCCCCCHHHCEEC	24.34	28551015
1656	Phosphorylation	FSTATSLSDLTIESP CCCCCCHHHCEECCC	30.27	28551015
1659	Phosphorylation	ATSLSDLTIESPPNE CCCHHHCEECCCCCC	27.91	28551015
1662	Phosphorylation	LSDLTIESPPNELAA HHHCEECCCCCCCCC	41.63	28551015
1695	Phosphorylation	IPTEGRSTDEAQRGK CCCCCCCCCHHHCCC	36.18	16641100
1714	Phosphorylation	AIPDLDGSKAEEGDI EECCCCCCCCCCCCH	28.49	16641100
1771	Phosphorylation	DTKKKKPTSPVKPMP CCCCCCCCCCCCCCC	55.32	28432305
1772	Phosphorylation	TKKKKPTSPVKPMPQ CCCCCCCCCCCCCCC	35.90	28432305
1799	Phosphorylation	DSKVNVNTEETFSDN CCCCCCCCHHHHCCC	30.80	30181290
1802	Phosphorylation	VNVNTEETFSDNKDS CCCCCHHHHCCCCHH	23.39	30181290
1804	Phosphorylation	VNTEETFSDNKDSKK CCCHHHHCCCCHHHH	47.93	28689409
1859	Phosphorylation	YCFSRNDSLSSLDFD CCCCCCCCCCCCCCC	33.43	27097102
1861	Phosphorylation	FSRNDSLSSLDFDDD CCCCCCCCCCCCCCC	32.57	28432305
1862	Phosphorylation	SRNDSLSSLDFDDDD CCCCCCCCCCCCCCC	36.93	21630457
1901	Phosphorylation	CHTEPSSSQQSARKA EECCCCCHHHHHHHH	36.25	27097102
1904	Phosphorylation	EPSSSQQSARKAQAS CCCCHHHHHHHHHHH	23.54	27097102
1930	Phosphorylation	PLLQEQPTFPQSSKD CCCCCCCCCCCCCCC	47.87	27097102
1934	Phosphorylation	EQPTFPQSSKDVPDR CCCCCCCCCCCCCCC	39.32	27097102
1935	Phosphorylation	QPTFPQSSKDVPDRG CCCCCCCCCCCCCCC	27.85	27097102
1962	Phosphorylation	ENTPVCFSRNSSLSS CCCCEEECCCCCCCC	25.98	27097102
1969	Phosphorylation	SRNSSLSSLSDVDQE CCCCCCCCHHHHCCC	36.87	-
1971	Phosphorylation	NSSLSSLSDVDQENN CCCCCCHHHHCCCCC	37.22	-
2010	Phosphorylation	ASGYAPKSFHVEDTP CCCCCCCEECCCCCC	21.37	27097102
2016	Phosphorylation	KSFHVEDTPVCFSRN CEECCCCCCEEECCC	12.24	27097102
2021	Phosphorylation	EDTPVCFSRNSSLSS CCCCEEECCCCCCCC	25.98	27097102
2087	Phosphorylation	KDIQRPESEHGLSPD HHCCCCHHHCCCCCC	37.26	27097102
2092	Phosphorylation	PESEHGLSPDSENFD CHHHCCCCCCCCCCC	31.11	27097102
2095	Phosphorylation	EHGLSPDSENFDWKA HCCCCCCCCCCCHHH	37.51	28432305
2109	Phosphorylation	AIQEGANSIVSSLHQ HHHHHHHHHHHHHHH	24.67	27097102
2112	Phosphorylation	EGANSIVSSLHQAAA HHHHHHHHHHHHHHH	26.05	27097102
2113	Phosphorylation	GANSIVSSLHQAAAA HHHHHHHHHHHHHHH	20.98	27097102
2125	Phosphorylation	AAAAACLSRQASSDS HHHHHHHHHHCCCCC	23.41	28432305
2129	Phosphorylation	ACLSRQASSDSDSIL HHHHHHCCCCCCCCE	26.75	27097102
2130	Phosphorylation	CLSRQASSDSDSILS HHHHHCCCCCCCCEE	44.12	27097102
2132	Phosphorylation	SRQASSDSDSILSLK HHHCCCCCCCCEECC	34.89	27097102
2134	Phosphorylation	QASSDSDSILSLKSG HCCCCCCCCEECCCC	29.40	28432305
2137	Phosphorylation	SDSDSILSLKSGVSL CCCCCCEECCCCCCC	31.89	22673903
2140	Phosphorylation	DSILSLKSGVSLGSP CCCEECCCCCCCCCC	50.12	28432305
2143	Phosphorylation	LSLKSGVSLGSPFHL EECCCCCCCCCCCCC	30.45	28432305
2146	Phosphorylation	KSGVSLGSPFHLTPD CCCCCCCCCCCCCCC	29.68	28432305
2151	Phosphorylation	LGSPFHLTPDQEEKP CCCCCCCCCCCCCCC	19.09	28432305
2160	Phosphorylation	DQEEKPFTSHKGPRI CCCCCCCCCCCCCCC	38.15	28432305
2161	Phosphorylation	QEEKPFTSHKGPRIL CCCCCCCCCCCCCCC	24.47	28432305
2205	Phosphorylation	LITGKIRSNSEISSQ HHHCCCCCCHHHHHH	48.45	28432305
2207	Phosphorylation	TGKIRSNSEISSQMK HCCCCCCHHHHHHHC	37.24	28432305
2210	Phosphorylation	IRSNSEISSQMKQPL CCCCHHHHHHHCCCH	15.51	28432305
2239	Phosphorylation	HIPGVRNSSSSTSPV ECCCCCCCCCCCCCC	22.49	22673903
2240	Phosphorylation	IPGVRNSSSSTSPVS CCCCCCCCCCCCCCC	31.68	22673903
2241	Phosphorylation	PGVRNSSSSTSPVSK CCCCCCCCCCCCCCC	37.14	22673903
2242	Phosphorylation	GVRNSSSSTSPVSKK CCCCCCCCCCCCCCC	34.55	28432305
2243	Phosphorylation	VRNSSSSTSPVSKKG CCCCCCCCCCCCCCC	38.71	28432305
2244	Phosphorylation	RNSSSSTSPVSKKGP CCCCCCCCCCCCCCC	25.83	28432305
2247	Phosphorylation	SSSTSPVSKKGPPLK CCCCCCCCCCCCCCC	31.84	22673903
2255	Phosphorylation	KKGPPLKTPASKSPS CCCCCCCCCCCCCCC	31.60	28432305
2258	Phosphorylation	PPLKTPASKSPSEGP CCCCCCCCCCCCCCC	34.56	27097102
2260	Phosphorylation	LKTPASKSPSEGPVA CCCCCCCCCCCCCCC	31.03	27097102
2262	Phosphorylation	TPASKSPSEGPVATT CCCCCCCCCCCCCCC	63.38	27097102
2268	Phosphorylation	PSEGPVATTSPRGTK CCCCCCCCCCCCCCC	28.21	27097102
2269	Phosphorylation	SEGPVATTSPRGTKP CCCCCCCCCCCCCCC	27.31	27097102
2270	Phosphorylation	EGPVATTSPRGTKPA CCCCCCCCCCCCCCC	14.30	27097102
2283	Phosphorylation	PAVKSELSPITRQTS CCCCCCCCCCCCCCC	15.37	25403869
2286	Phosphorylation	KSELSPITRQTSHIS CCCCCCCCCCCCCCC	21.80	22673903
2302	Phosphorylation	SNKGPSRSGSRDSTP CCCCCCCCCCCCCCC	45.52	28432305
2304	Phosphorylation	KGPSRSGSRDSTPSR CCCCCCCCCCCCCCC	33.87	28432305
2307	Phosphorylation	SRSGSRDSTPSRPTQ CCCCCCCCCCCCCCC	40.90	28432305
2323	Phosphorylation	PLSRPMQSPGRNSIS CCCCCCCCCCCCCCC	24.06	27097102
2328	Phosphorylation	MQSPGRNSISPGRNG CCCCCCCCCCCCCCC	24.07	27097102
2330	Phosphorylation	SPGRNSISPGRNGIS CCCCCCCCCCCCCCC	22.56	23984901
2358	Phosphorylation	PSTASTKSSGSGKMS CCCCCCCCCCCCCCC	39.77	28689409
2365	Phosphorylation	SSGSGKMSYTSPGRQ CCCCCCCCCCCCCCC	28.83	23298284
2367	Phosphorylation	GSGKMSYTSPGRQLS CCCCCCCCCCCCCCH	22.57	27097102
2368	Phosphorylation	SGKMSYTSPGRQLSQ CCCCCCCCCCCCCHH	19.68	27097102
2374	Phosphorylation	TSPGRQLSQQNLSKQ CCCCCCCHHHHHHHH	22.75	28432305
2390	Phosphorylation	GLSKNASSIPRSESA CCCCCHHHCCCCHHH	33.91	23984901
2394	Phosphorylation	NASSIPRSESASKGL CHHHCCCCHHHHHHH	30.46	23984901
2396	Phosphorylation	SSIPRSESASKGLNQ HHCCCCHHHHHHHHH	38.80	23984901
2398	Phosphorylation	IPRSESASKGLNQMN CCCCHHHHHHHHHHH	36.21	23984901
2410	Phosphorylation	QMNNSNGSNKKVELS HHHCCCCCCCCEEEE	50.13	27097102
2449	Phosphorylation	TFIKEAPSPTLRRKL HHCCCCCCHHHHHHH	37.25	29779826
2451	Phosphorylation	IKEAPSPTLRRKLEE CCCCCCHHHHHHHHH	36.92	22673903
2459	Phosphorylation	LRRKLEESASFESLS HHHHHHHHCCCCCCC	21.60	27097102
2461	Phosphorylation	RKLEESASFESLSPS HHHHHHCCCCCCCCC	38.53	27097102
2464	Phosphorylation	EESASFESLSPSSRP HHHCCCCCCCCCCCC	31.94	27097102
2466	Phosphorylation	SASFESLSPSSRPDS HCCCCCCCCCCCCCC	31.83	27097102
2468	Phosphorylation	SFESLSPSSRPDSPT CCCCCCCCCCCCCCC	35.29	27097102
2469	Phosphorylation	FESLSPSSRPDSPTR CCCCCCCCCCCCCCC	51.74	27097102
2473	Phosphorylation	SPSSRPDSPTRSQAQ CCCCCCCCCCCCCCC	30.74	27097102
2475	Phosphorylation	SSRPDSPTRSQAQTP CCCCCCCCCCCCCCC	47.07	27097102
2512	Phosphorylation	RKLPPNLSPTIEYSD CCCCCCCCCCEECCC	27.00	30240740
2531	Phosphorylation	KRHDIARSHSESPSR CCHHHHHCCCCCCCC	23.49	27097102
2533	Phosphorylation	HDIARSHSESPSRLP HHHHHCCCCCCCCCC	40.80	27097102
2535	Phosphorylation	IARSHSESPSRLPVN HHHCCCCCCCCCCCC	31.06	27097102
2537	Phosphorylation	RSHSESPSRLPVNRA HCCCCCCCCCCCCCC	56.58	27097102
2556	Phosphorylation	REHSKHSSSLPRVST CCCCCCCCCCCCEEC	35.30	28432305
2557	Phosphorylation	EHSKHSSSLPRVSTW CCCCCCCCCCCEECC	45.46	28432305
2567	Phosphorylation	RVSTWRRTGSSSSIL CEECCCCCCCCHHHH	32.61	27097102
2569	Phosphorylation	STWRRTGSSSSILSA ECCCCCCCCHHHHCC	26.83	27097102
2570	Phosphorylation	TWRRTGSSSSILSAS CCCCCCCCHHHHCCC	29.47	27097102
2571	Phosphorylation	WRRTGSSSSILSASS CCCCCCCHHHHCCCC	24.08	23984901
2572	Phosphorylation	RRTGSSSSILSASSE CCCCCCHHHHCCCCC	29.51	23984901
2575	Phosphorylation	GSSSSILSASSESSE CCCHHHHCCCCCCHH	25.16	25575281
2578	Phosphorylation	SSILSASSESSEKAK HHHHCCCCCCHHHHH	41.01	28689409
2580	Phosphorylation	ILSASSESSEKAKSE HHCCCCCCHHHHHCC	45.83	28689409
2581	Phosphorylation	LSASSESSEKAKSED HCCCCCCHHHHHCCC	38.78	28689409
2586	Phosphorylation	ESSEKAKSEDEKHVN CCHHHHHCCCHHHCC	55.96	25575281
2618	Phosphorylation	TWRKIKESEISPTNT CHHCCHHHHCCCCCC	34.92	23984901
2621	Phosphorylation	KIKESEISPTNTVSQ CCHHHHCCCCCCCEE	22.94	27097102
2623	Phosphorylation	KESEISPTNTVSQTT HHHHCCCCCCCEEEC	36.41	23984901
2625	Phosphorylation	SEISPTNTVSQTTSS HHCCCCCCCEEECCC	24.82	23984901
2627	Phosphorylation	ISPTNTVSQTTSSGA CCCCCCCEEECCCCC	21.55	27097102
2629	Phosphorylation	PTNTVSQTTSSGAAS CCCCCEEECCCCCCC	22.57	27097102
2630	Phosphorylation	TNTVSQTTSSGAASG CCCCEEECCCCCCCC	17.17	27097102
2631	Phosphorylation	NTVSQTTSSGAASGA CCCEEECCCCCCCCC	30.11	27097102
2632	Phosphorylation	TVSQTTSSGAASGAE CCEEECCCCCCCCCC	30.29	27097102
2671	Phosphorylation	CPINNPRSGRSPTGN CCCCCCCCCCCCCCC	39.55	27097102
2674	Phosphorylation	NNPRSGRSPTGNTPP CCCCCCCCCCCCCCC	30.27	27097102
2676	Phosphorylation	PRSGRSPTGNTPPVI CCCCCCCCCCCCCCC	44.29	27097102
2679	Phosphorylation	GRSPTGNTPPVIDSI CCCCCCCCCCCCHHH	30.25	27097102
2705	Phosphorylation	KDTQGKQSVGSGSPV CCCCCCCCCCCCCCC	31.75	27097102
2708	Phosphorylation	QGKQSVGSGSPVQTV CCCCCCCCCCCCEEE	33.66	27097102
2710	Phosphorylation	KQSVGSGSPVQTVGL CCCCCCCCCCEEECC	24.48	21738781
2714	Phosphorylation	GSGSPVQTVGLENRL CCCCCCEEECCHHHH	19.44	25403869
2723	Phosphorylation	GLENRLNSFIQVEAP CCHHHHHCCEEEECC	28.46	29779826
2759	Phosphorylation	ETCMAERTPFSSSSS CCCCCCCCCCCCCCC	21.86	25575281
2762	Phosphorylation	MAERTPFSSSSSSKH CCCCCCCCCCCCCCC	30.43	27097102
2763	Phosphorylation	AERTPFSSSSSSKHS CCCCCCCCCCCCCCC	34.32	27097102
2764	Phosphorylation	ERTPFSSSSSSKHSS CCCCCCCCCCCCCCC	32.80	27097102
2765	Phosphorylation	RTPFSSSSSSKHSSP CCCCCCCCCCCCCCC	40.35	27097102
2766	Phosphorylation	TPFSSSSSSKHSSPS CCCCCCCCCCCCCCC	45.41	27097102
2767	Phosphorylation	PFSSSSSSKHSSPSG CCCCCCCCCCCCCCC	36.01	27097102
2770	Phosphorylation	SSSSSKHSSPSGTVA CCCCCCCCCCCCCEE	47.91	28432305
2771	Phosphorylation	SSSSKHSSPSGTVAA CCCCCCCCCCCCEEE	23.86	27097102
2773	Phosphorylation	SSKHSSPSGTVAARV CCCCCCCCCCEEEEE	49.39	28432305
2775	Phosphorylation	KHSSPSGTVAARVTP CCCCCCCCEEEEECC	16.00	28432305
2788	Phosphorylation	TPFNYNPSPRKSSAD CCCCCCCCCCCCCCC	33.43	28432305
2792	Phosphorylation	YNPSPRKSSADSTSA CCCCCCCCCCCCCCC	31.85	28432305
2793	Phosphorylation	NPSPRKSSADSTSAR CCCCCCCCCCCCCCC	38.85	28432305
2796	Phosphorylation	PRKSSADSTSARPSQ CCCCCCCCCCCCHHH	24.79	25575281
2797	Phosphorylation	RKSSADSTSARPSQI CCCCCCCCCCCHHHC	27.27	25575281
2798	Phosphorylation	KSSADSTSARPSQIP CCCCCCCCCCHHHCC	26.66	25575281
2802	Phosphorylation	DSTSARPSQIPTPVG CCCCCCHHHCCCCCC	34.88	25575281
2806	Phosphorylation	ARPSQIPTPVGSSTK CCHHHCCCCCCCCCC	32.03	27097102
2810	Phosphorylation	QIPTPVGSSTKKRDS HCCCCCCCCCCCCCC	34.76	27097102
2811	Phosphorylation	IPTPVGSSTKKRDSK CCCCCCCCCCCCCCC	38.01	27097102
2812	Phosphorylation	PTPVGSSTKKRDSKT CCCCCCCCCCCCCCC	42.13	27097102
2829	Phosphorylation	TESSGAQSPKRHSGS CCCCCCCCCCCCCCC	31.67	29779826
2834	Phosphorylation	AQSPKRHSGSYLVTS CCCCCCCCCCEEEEC	33.20	27097102
2836	Phosphorylation	SPKRHSGSYLVTSV- CCCCCCCCEEEECC-	20.50	27097102
2837	Phosphorylation	PKRHSGSYLVTSV-- CCCCCCCEEEECC--	14.55	23984901
2840	Phosphorylation	HSGSYLVTSV----- CCCCEEEECC-----	22.60	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APC_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APC_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTN13_HUMAN	PTPN13	physical	10951583
AXIN1_RAT	Axin1	physical	16815997
CTNB1_RAT	Ctnnb1	physical	16815997
GSK3B_RAT	Gsk3b	physical	16815997

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites.";
Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1178; THR-1695 ANDSER-1714, AND MASS SPECTROMETRY.
PubMed: 16641100