EMAL5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMAL5_HUMAN
• UniProt AC: Q05BV3
• Protein Name: Echinoderm microtubule-associated protein-like 5
• Gene Name: EML5
• Organism: Homo sapiens (Human).
• Sequence Length: 1969
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic..
• Protein Sequence: MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERVLVATGQVGKEPYICIWDSYTVQTISVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHAAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETDQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVQERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRLFYRMPGGKEVTSTEEIKGVHWASWTCVSGLEVNGIWPKYSDINDINSVDGNYIGQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDAVHIAPQESLADSHSDESDSDLSDVPELDSEIEQETQLTYRRQVYKEDLPQLKEQCKEKQKSATSKRRERAPGNSIRLHFVHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLTIHPLKDYVATGQVGRDPSIHIWDTETIKPLSILKGHHQYGVSAVDFSADGKRLASVGIDDSHTVVLWDWKKGEKLSIARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRKAGGGLIGRKGYIGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDIFLVKTVKAHDGPVFSMHALEKGFVTGGKDGIVALWDDSFERCLKTYAIKRAALAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPITLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDMISDIRFSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWTYDDSMLVTLGGTDMSLMVWTNEMEGYREKRPCDSEESDIDSEEDGGYDSDVTRENEISYTIRALSTNIRPMLGIKPHLQQKEPSIDERPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCSVSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATDCVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSLFVWKCVHTPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	TAAKEIVYFVAGVGV HCHHHHHEEEECCCC	9.67	-
47	Phosphorylation	VAGVGVVYSPREHRQ EECCCCEECCHHHHH	15.56	-
144	Phosphorylation	WKRGKMLSMAPGHTD CCCCCEEECCCCCCC	14.92	-
150	Phosphorylation	LSMAPGHTDRIFDIS EECCCCCCCEEEEEC	32.65	29759185
178	Phosphorylation	VKHIKFWSLCGNALT CCEEEHHHHCCCCCC	19.53	26270265
185	Phosphorylation	SLCGNALTPKRGVFG HHCCCCCCCCCCCCC	25.10	26270265
187	Ubiquitination	CGNALTPKRGVFGKT CCCCCCCCCCCCCCC	57.45	-
285	Phosphorylation	DQGYKGLSVRSVCWR CCCCCCEEEEEEEEC	24.93	24719451
342	Phosphorylation	PTKPLAVTGSDDRSV CCCCEEECCCCCCCC	25.92	23909892
344	Phosphorylation	KPLAVTGSDDRSVRI CCEEECCCCCCCCHH	27.29	23909892
348	Phosphorylation	VTGSDDRSVRIWSLV ECCCCCCCCHHHHHH	23.81	23909892
474	Methylation	QTNDGNGKRLFYRMP EECCCCCCEEEEECC	50.34	-
547	Phosphorylation	GIIKLFRYPCLRKGA CHHHHHCCHHHCCCC	7.32	30108239
663	Phosphorylation	QCKEKQKSATSKRRE HHHHHHHHHHHHHHH	33.99	26657352
665	Phosphorylation	KEKQKSATSKRRERA HHHHHHHHHHHHHCC	41.70	26657352
666	Phosphorylation	EKQKSATSKRRERAP HHHHHHHHHHHHCCC	24.71	26657352
676	Phosphorylation	RERAPGNSIRLHFVH HHCCCCCCEEEEEEC	18.27	-
696	Phosphorylation	DCRSNLFYTQIGEIV CCCCCEEEEHHHHHH	10.82	22817900
765	Phosphorylation	TETIKPLSILKGHHQ CCCCCCEECCCCCCC	34.11	24719451
789	Phosphorylation	ADGKRLASVGIDDSH CCCCEEEEEECCCCC	26.01	-
815	Phosphorylation	KLSIARGSKDKIFVV EEEEEECCCCCEEEE	31.93	22496350
831	Acetylation	MNPYVPDKLITAGIK CCCCCCHHHHHCCCC	35.40	12439175
838	Acetylation	KLITAGIKHMKFWRK HHHHCCCCCHHHHHH	36.41	12439187
898	Phosphorylation	RDIFLVKTVKAHDGP EEEEEEEEEECCCCC	21.54	22210691
918	Phosphorylation	ALEKGFVTGGKDGIV EECCCCCCCCCCCEE	37.65	22210691
938	Phosphorylation	SFERCLKTYAIKRAA HHHHHHHHHHHHHHH	12.77	22210691
939	Phosphorylation	FERCLKTYAIKRAAL HHHHHHHHHHHHHHC	12.54	22210691
951 (in isoform 5)	Ubiquitination	-	60.54	-
1086	Phosphorylation	HHRKDMISDIRFSPG HHCCCCCCEEEECCC	21.98	24719451
1094	Phosphorylation	DIRFSPGSGKYLAVA EEEECCCCCCEEEEE	35.18	-
1138	Ubiquitination	IDWDIRGKLLQVNTG ECEECCCCEEEECCC	35.85	-
1281	Phosphorylation	REKRPCDSEESDIDS CCCCCCCCCCCCCCC	50.40	27732954
1284	Phosphorylation	RPCDSEESDIDSEED CCCCCCCCCCCCCCC	35.50	27732954
1288	Phosphorylation	SEESDIDSEEDGGYD CCCCCCCCCCCCCCC	43.13	27732954
1294	Phosphorylation	DSEEDGGYDSDVTRE CCCCCCCCCCCCCCC	20.15	27732954
1296	Phosphorylation	EEDGGYDSDVTRENE CCCCCCCCCCCCCHH	26.04	27732954
1299	Phosphorylation	GGYDSDVTRENEISY CCCCCCCCCCHHHHH	36.94	27732954
1306	Phosphorylation	TRENEISYTIRALST CCCHHHHHHHHHHHC	16.31	22817900
1307	Phosphorylation	RENEISYTIRALSTN CCHHHHHHHHHHHCC	9.37	24719451
1508	Phosphorylation	QEGAKIASRAGHNQR CCCCCHHHHCCCCCE	26.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMAL5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMAL5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMAL5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EMAL5_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.