LPIN1_HUMAN - dbPTM
LPIN1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LPIN1_HUMAN
UniProt AC Q14693
Protein Name Phosphatidate phosphatase LPIN1
Gene Name LPIN1
Organism Homo sapiens (Human).
Sequence Length 890
Subcellular Localization Nucleus membrane. Cytoplasm, cytosol. Endoplasmic reticulum membrane.
Protein Description Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity)..
Protein Sequence MNYVGQLAGQVFVTVKELYKGLNPATLSGCIDIIVIRQPNGNLQCSPFHVRFGKMGVLRSREKVVDIEINGESVDLHMKLGDNGEAFFVQETDNDQEVIPMHLATSPILSEGASRMECQLKRGSVDRMRGLDPSTPAQVIAPSETPSSSSVVKKRRKRRRKSQLDSLKRDDNMNTSEDEDMFPIEMSSDEAMELLESSRTLPNDIPPFQDDIPEENLSLAVIYPQSASYPNSDREWSPTPSPSGSRPSTPKSDSELVSKSTERTGQKNPEMLWLWGELPQAAKSSSPHKMKESSPLSSRKICDKSHFQAIHSESSDTFSDQSPTLVGGALLDQNKPQTEMQFVNEEDLETLGAAAPLLPMIEELKPPSASVVQTANKTDSPSRKRDKRSRHLGADGVYLDDLTDMDPEVAALYFPKNGDPSGLAKHASDNGARSANQSPQSVGSSGVDSGVESTSDGLRDLPSIAISLCGGLSDHREITKDAFLEQAVSYQQFVDNPAIIDDPNLVVKIGSKYYNWTTAAPLLLAMQAFQKPLPKATVESIMRDKMPKKGGRWWFSWRGRNTTIKEESKPEQCLAGKAHSTGEQPPQLSLATRVKHESSSSDEERAAAKPSNAGHLPLLPNVSYKKTLRLTSEQLKSLKLKNGPNDVVFSVTTQYQGTCRCEGTIYLWNWDDKVIISDIDGTITRSDTLGHILPTLGKDWTHQGIAKLYHKVSQNGYKFLYCSARAIGMADMTRGYLHWVNERGTVLPQGPLLLSPSSLFSALHREVIEKKPEKFKVQCLTDIKNLFFPNTEPFYAAFGNRPADVYSYKQVGVSLNRIFTVNPKGELVQEHAKTNISSYVRLCEVVDHVFPLLKRSHSSDFPCSDTFSNFTFWREPLPPFENQDIHSASA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MNYVGQLAGQ
-----CCCHHHHCCC		12.5022210691
14PhosphorylationLAGQVFVTVKELYKG
HCCCEEEEHHHHHCC		17.8824043423
54UbiquitinationPFHVRFGKMGVLRSR
CCEEECCCCCEECCC		29.75-
60UbiquitinationGKMGVLRSREKVVDI
CCCCEECCCCEEEEE		40.40-
92PhosphorylationEAFFVQETDNDQEVI
CEEEEEECCCCCEEE		24.0228102081
103UbiquitinationQEVIPMHLATSPILS
CEEEEEEEECCCCCC		4.53-
105PhosphorylationVIPMHLATSPILSEG
EEEEEEECCCCCCCC		41.2028450419
106PhosphorylationIPMHLATSPILSEGA
EEEEEECCCCCCCCC		12.3430183078
110PhosphorylationLATSPILSEGASRME
EECCCCCCCCCCCCC		34.4028450419
114PhosphorylationPILSEGASRMECQLK
CCCCCCCCCCCEEHH		42.9128450419
134PhosphorylationRMRGLDPSTPAQVIA
HHCCCCCCCCCEEEC		46.8425850435
135PhosphorylationMRGLDPSTPAQVIAP
HCCCCCCCCCEEECC		28.2125850435
143PhosphorylationPAQVIAPSETPSSSS
CCEEECCCCCCCCHH		45.1130177828
145PhosphorylationQVIAPSETPSSSSVV
EEECCCCCCCCHHHH		32.5722199227
147PhosphorylationIAPSETPSSSSVVKK
ECCCCCCCCHHHHHH		50.7222199227
148PhosphorylationAPSETPSSSSVVKKR
CCCCCCCCHHHHHHH		28.0322199227
149PhosphorylationPSETPSSSSVVKKRR
CCCCCCCHHHHHHHH		31.3328348404
150PhosphorylationSETPSSSSVVKKRRK
CCCCCCHHHHHHHHH		32.6422199227
155 (in isoform 7)Phosphorylation-43.5727251275
162PhosphorylationRRKRRRKSQLDSLKR
HHHHHHHHHHHHHCC		33.8823401153
166PhosphorylationRRKSQLDSLKRDDNM
HHHHHHHHHCCCCCC		44.3730266825
168PhosphorylationKSQLDSLKRDDNMNT
HHHHHHHCCCCCCCC		58.7032142685
175PhosphorylationKRDDNMNTSEDEDMF
CCCCCCCCCCCCCCC		23.7920071362
176PhosphorylationRDDNMNTSEDEDMFP
CCCCCCCCCCCCCCE		37.7420071362
187PhosphorylationDMFPIEMSSDEAMEL
CCCEECCCHHHHHHH		23.1120071362
188PhosphorylationMFPIEMSSDEAMELL
CCEECCCHHHHHHHH		37.8520071362
192PhosphorylationEMSSDEAMELLESSR
CCCHHHHHHHHHHCC		3.3332142685
211PhosphorylationDIPPFQDDIPEENLS
CCCCCCCCCCHHCCE		47.7832142685
211 (in isoform 7)Phosphorylation-47.7827251275
212AcetylationIPPFQDDIPEENLSL
CCCCCCCCCHHCCEE		6.60-
225 (in isoform 7)Phosphorylation-34.3627251275
237PhosphorylationPNSDREWSPTPSPSG
CCCCCCCCCCCCCCC		17.7227732954
237 (in isoform 3)Phosphorylation-17.7225850435
239PhosphorylationSDREWSPTPSPSGSR
CCCCCCCCCCCCCCC		30.7727732954
239 (in isoform 3)Phosphorylation-30.7725850435
241PhosphorylationREWSPTPSPSGSRPS
CCCCCCCCCCCCCCC		33.8927732954
241 (in isoform 3)Phosphorylation-33.8925850435
242 (in isoform 3)Phosphorylation-43.8625850435
243PhosphorylationWSPTPSPSGSRPSTP
CCCCCCCCCCCCCCC		54.4627732954
243 (in isoform 5)Phosphorylation-54.4625850435
243 (in isoform 6)Phosphorylation-54.4625850435
245PhosphorylationPTPSPSGSRPSTPKS
CCCCCCCCCCCCCCC		45.4127732954
245 (in isoform 5)Phosphorylation-45.4125850435
245 (in isoform 6)Phosphorylation-45.4125850435
247 (in isoform 5)Phosphorylation-44.2325850435
247 (in isoform 6)Phosphorylation-44.2325850435
248PhosphorylationSPSGSRPSTPKSDSE
CCCCCCCCCCCCHHH		57.1223663014
248 (in isoform 5)Phosphorylation-57.1225850435
248 (in isoform 6)Phosphorylation-57.1225850435
249PhosphorylationPSGSRPSTPKSDSEL
CCCCCCCCCCCHHHH		37.1023663014
252PhosphorylationSRPSTPKSDSELVSK
CCCCCCCCHHHHHCC		47.8030266825
254PhosphorylationPSTPKSDSELVSKST
CCCCCCHHHHHCCCC		39.6629255136
258PhosphorylationKSDSELVSKSTERTG
CCHHHHHCCCCCCCC		33.2523663014
260PhosphorylationDSELVSKSTERTGQK
HHHHHCCCCCCCCCC		28.17-
264PhosphorylationVSKSTERTGQKNPEM
HCCCCCCCCCCCHHH		37.42-
264 (in isoform 3)Phosphorylation-37.42-
269 (in isoform 3)Phosphorylation-35.10-
270 (in isoform 3)Phosphorylation-57.19-
270 (in isoform 5)Phosphorylation-57.19-
270 (in isoform 6)Phosphorylation-57.19-
275 (in isoform 5)Phosphorylation-6.14-
275 (in isoform 6)Phosphorylation-6.14-
276 (in isoform 5)Phosphorylation-25.13-
276 (in isoform 6)Phosphorylation-25.13-
284PhosphorylationELPQAAKSSSPHKMK
CCCHHHHHCCCCCCC		31.1823927012
285PhosphorylationLPQAAKSSSPHKMKE
CCHHHHHCCCCCCCC		47.3723927012
286PhosphorylationPQAAKSSSPHKMKES
CHHHHHCCCCCCCCC		37.8130576142
286 (in isoform 7)Phosphorylation-37.8125850435
288 (in isoform 3)Phosphorylation-44.8029743597
288 (in isoform 7)Phosphorylation-44.8025850435
290 (in isoform 3)Phosphorylation-5.4629743597
290 (in isoform 7)Phosphorylation-5.4625850435
291 (in isoform 7)Phosphorylation-60.2825850435
293PhosphorylationSPHKMKESSPLSSRK
CCCCCCCCCCCCCCC		31.5623927012
294PhosphorylationPHKMKESSPLSSRKI
CCCCCCCCCCCCCCC		30.8323401153
294 (in isoform 5)Phosphorylation-30.8329743597
294 (in isoform 6)Phosphorylation-30.8329743597
296 (in isoform 5)Phosphorylation-8.6229743597
296 (in isoform 6)Phosphorylation-8.6229743597
297PhosphorylationMKESSPLSSRKICDK
CCCCCCCCCCCCCCH		31.3323927012
298PhosphorylationKESSPLSSRKICDKS
CCCCCCCCCCCCCHH		45.3223927012
300PhosphorylationSSPLSSRKICDKSHF
CCCCCCCCCCCHHHH		50.0332645325
313 (in isoform 7)Phosphorylation-39.85-
318 (in isoform 7)Phosphorylation-10.20-
319 (in isoform 7)Phosphorylation-36.51-
329PhosphorylationSPTLVGGALLDQNKP
CCCEECCEECCCCCC		10.0632645325
330PhosphorylationPTLVGGALLDQNKPQ
CCEECCEECCCCCCC		6.4832645325
337 (in isoform 7)Phosphorylation-52.2629743597
339 (in isoform 7)Phosphorylation-26.2429743597
343PhosphorylationPQTEMQFVNEEDLET
CCCCEEECCHHHHHH		5.0532645325
355UbiquitinationLETLGAAAPLLPMIE
HHHHHHHHHHHHHHH		8.50-
360PhosphorylationAAAPLLPMIEELKPP
HHHHHHHHHHHHCCC		6.4232645325
378 (in isoform 7)Phosphorylation-41.3327251275
379PhosphorylationVQTANKTDSPSRKRD
EEECCCCCCCCCHHH		61.2232645325
379 (in isoform 7)Phosphorylation-61.2227251275
434PhosphorylationASDNGARSANQSPQS
CCCCCCCCCCCCCCC		30.9123927012
438PhosphorylationGARSANQSPQSVGSS
CCCCCCCCCCCCCCC		25.3925159151
441PhosphorylationSANQSPQSVGSSGVD
CCCCCCCCCCCCCCC		31.6525159151
444PhosphorylationQSPQSVGSSGVDSGV
CCCCCCCCCCCCCCC		23.0529978859
445PhosphorylationSPQSVGSSGVDSGVE
CCCCCCCCCCCCCCC		36.5929978859
449PhosphorylationVGSSGVDSGVESTSD
CCCCCCCCCCCCCCC		42.1923401153
453PhosphorylationGVDSGVESTSDGLRD
CCCCCCCCCCCCCCC		30.7023927012
454PhosphorylationVDSGVESTSDGLRDL
CCCCCCCCCCCCCCC		19.8223927012
455PhosphorylationDSGVESTSDGLRDLP
CCCCCCCCCCCCCCC		38.6733259812
479PhosphorylationLSDHREITKDAFLEQ
CCCCCHHCHHHHHHH		20.37-
480UbiquitinationSDHREITKDAFLEQA
CCCCHHCHHHHHHHH		53.3629967540
484PhosphorylationEITKDAFLEQAVSYQ
HHCHHHHHHHHCCHH		5.2333259812
485PhosphorylationITKDAFLEQAVSYQQ
HCHHHHHHHHCCHHH		30.0033259812
486UbiquitinationTKDAFLEQAVSYQQF
CHHHHHHHHCCHHHH		49.5729967540
498PhosphorylationQQFVDNPAIIDDPNL
HHHCCCCCCCCCCCE		20.0233259812
515PhosphorylationKIGSKYYNWTTAAPL
EECCCCCCHHHHHHH		26.9133259812
523 (in isoform 7)Phosphorylation-2.5227251275
529 (in isoform 7)Phosphorylation-5.5927251275
534PhosphorylationQAFQKPLPKATVESI
HHHCCCCCCCHHHHH		32.5333259812
562PhosphorylationFSWRGRNTTIKEESK
EEECCCCCCCCCCCC		28.6526434776
563PhosphorylationSWRGRNTTIKEESKP
EECCCCCCCCCCCCH		33.3329214152
565UbiquitinationRGRNTTIKEESKPEQ
CCCCCCCCCCCCHHH		54.0229967540
568PhosphorylationNTTIKEESKPEQCLA
CCCCCCCCCHHHHHC		55.3826434776
580PhosphorylationCLAGKAHSTGEQPPQ
HHCCCCCCCCCCCCC		42.8625159151
598PhosphorylationATRVKHESSSSDEER
EEECCCCCCCCHHHH		34.9326699800
599PhosphorylationTRVKHESSSSDEERA
EECCCCCCCCHHHHH		30.7726699800
600PhosphorylationRVKHESSSSDEERAA
ECCCCCCCCHHHHHH		51.6025159151
601PhosphorylationVKHESSSSDEERAAA
CCCCCCCCHHHHHHH		51.4925159151
609UbiquitinationDEERAAAKPSNAGHL
HHHHHHHCCCCCCCC		44.2329967540
611PhosphorylationERAAAKPSNAGHLPL
HHHHHCCCCCCCCCC		38.3129514088
615UbiquitinationAKPSNAGHLPLLPNV
HCCCCCCCCCCCCCC		23.1229967540
636UbiquitinationRLTSEQLKSLKLKNG
ECCHHHHHHCCCCCC		54.1329967540
642UbiquitinationLKSLKLKNGPNDVVF
HHHCCCCCCCCCEEE		79.9729967540
686PhosphorylationIDGTITRSDTLGHIL
CCCCEECHHHHHHHC		26.7123312004
688PhosphorylationGTITRSDTLGHILPT
CCEECHHHHHHHCCC		35.5723312004
694UbiquitinationDTLGHILPTLGKDWT
HHHHHHCCCCCCCCC		25.6029967540
698UbiquitinationHILPTLGKDWTHQGI
HHCCCCCCCCCHHHH		53.8829967540
704UbiquitinationGKDWTHQGIAKLYHK
CCCCCHHHHHHHHHH		17.7629967540
707UbiquitinationWTHQGIAKLYHKVSQ
CCHHHHHHHHHHHHH		47.8929967540
711AcetylationGIAKLYHKVSQNGYK
HHHHHHHHHHHCCCE		29.9923236377
711UbiquitinationGIAKLYHKVSQNGYK
HHHHHHHHHHHCCCE		29.9929967540
713PhosphorylationAKLYHKVSQNGYKFL
HHHHHHHHHCCCEEE		23.80-
713UbiquitinationAKLYHKVSQNGYKFL
HHHHHHHHHCCCEEE		23.8029967540
717PhosphorylationHKVSQNGYKFLYCSA
HHHHHCCCEEEEECH		13.20-
717UbiquitinationHKVSQNGYKFLYCSA
HHHHHCCCEEEEECH		13.2029967540
721UbiquitinationQNGYKFLYCSARAIG
HCCCEEEEECHHHHC		6.3629967540
770UbiquitinationLHREVIEKKPEKFKV
HHHHHHHHCCHHCEE		63.60-
773 (in isoform 7)Phosphorylation-78.8527251275
776UbiquitinationEKKPEKFKVQCLTDI
HHCCHHCEEEEEHHC		42.3329967540
782UbiquitinationFKVQCLTDIKNLFFP
CEEEEEHHCHHCCCC		36.6029967540
783UbiquitinationKVQCLTDIKNLFFPN
EEEEEHHCHHCCCCC		2.4129967540
792UbiquitinationNLFFPNTEPFYAAFG
HCCCCCCCCCHHHCC		39.8029967540
796UbiquitinationPNTEPFYAAFGNRPA
CCCCCCHHHCCCCCC		9.1929967540
854UbiquitinationDHVFPLLKRSHSSDF
HHHHHHHCCCCCCCC		60.58-
856PhosphorylationVFPLLKRSHSSDFPC
HHHHHCCCCCCCCCC		26.5727251275
858PhosphorylationPLLKRSHSSDFPCSD
HHHCCCCCCCCCCCC		32.6126657352
859PhosphorylationLLKRSHSSDFPCSDT
HHCCCCCCCCCCCCC		37.5428348404
861UbiquitinationKRSHSSDFPCSDTFS
CCCCCCCCCCCCCCC		7.6929967540
887PhosphorylationFENQDIHSASA----
CCCCCCCCCCC----		25.0130266825
889PhosphorylationNQDIHSASA------
CCCCCCCCC------		37.2130266825
939Ubiquitination--------------------------------------------------------
--------------------------------------------------------		-
941 (in isoform 7)Phosphorylation-27251275
974 (in isoform 7)Phosphorylation-27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LPIN1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LPIN1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LPIN1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NFAC4_HUMANNFATC4physical
20385772
PPARA_HUMANPPARAphysical
20385772
PAH1_YEASTPAH1genetic
20583302
FBW1A_HUMANBTRCphysical
28049764
CUL1_HUMANCUL1physical
28049764
KC1E_HUMANCSNK1Ephysical
28049764
Drug and Disease Associations
Kegg Disease
H01290 Acute recurrent myoglobinuria
OMIM Disease
268200Myoglobinuria, acute recurrent, autosomal recessive (ARARM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LPIN1_HUMAN

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Related Literatures of Post-Translational Modification

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