RASF3_HUMAN - dbPTM
RASF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RASF3_HUMAN
UniProt AC Q86WH2
Protein Name Ras association domain-containing protein 3
Gene Name RASSF3
Organism Homo sapiens (Human).
Sequence Length 238
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton . Localized to microtubules in vascular endothelial cells.
Protein Description
Protein Sequence MSSGYSSLEEDAEDFFFTARTSFFRRAPQGKPRSGQQDVEKEKETHSYLSKEEIKEKVHKYNLAVTDKLKMTLNSNGIYTGFIKVQMELCKPPQTSPNSGKLSPSSNGCMNTLHISSTNTVGEVIEALLKKFLVTESPAKFALYKRCHREDQVYACKLSDREHPLYLRLVAGPRTDTLSFVLREHEIGEWEAFSLPELQNFLRILDKEEDEQLQNLKRRYTAYRQKLEEALREVWKPD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSGYSSLE
------CCCCCCCHH		32.2530108239
2Acetylation------MSSGYSSLE
------CCCCCCCHH		32.2519369195
3Phosphorylation-----MSSGYSSLEE
-----CCCCCCCHHH		40.2130108239
5Phosphorylation---MSSGYSSLEEDA
---CCCCCCCHHHHH		9.3130108239
6Phosphorylation--MSSGYSSLEEDAE
--CCCCCCCHHHHHH		31.7830108239
7Phosphorylation-MSSGYSSLEEDAED
-CCCCCCCHHHHHHH		31.1730108239
18PhosphorylationDAEDFFFTARTSFFR
HHHHHHHHHHHHHHH		15.2929759185
22PhosphorylationFFFTARTSFFRRAPQ
HHHHHHHHHHHCCCC		19.4824719451
31UbiquitinationFRRAPQGKPRSGQQD
HHCCCCCCCCCCCCC		31.8229967540
41UbiquitinationSGQQDVEKEKETHSY
CCCCCHHHHHHHHCC		74.1427667366
45PhosphorylationDVEKEKETHSYLSKE
CHHHHHHHHCCCCHH		27.4730206219
47PhosphorylationEKEKETHSYLSKEEI
HHHHHHHCCCCHHHH		34.8830206219
48PhosphorylationKEKETHSYLSKEEIK
HHHHHHCCCCHHHHH		13.8530206219
51UbiquitinationETHSYLSKEEIKEKV
HHHCCCCHHHHHHHH		57.6929967540
72PhosphorylationVTDKLKMTLNSNGIY
CCCCEEEEECCCCCE		22.6219369195
79PhosphorylationTLNSNGIYTGFIKVQ
EECCCCCEEEEEEEE		11.38-
84UbiquitinationGIYTGFIKVQMELCK
CCEEEEEEEEEEECC		24.93-
91UbiquitinationKVQMELCKPPQTSPN
EEEEEECCCCCCCCC		72.81-
95PhosphorylationELCKPPQTSPNSGKL
EECCCCCCCCCCCCC		52.5028985074
96PhosphorylationLCKPPQTSPNSGKLS
ECCCCCCCCCCCCCC		19.4828348404
137PhosphorylationKKFLVTESPAKFALY
HHHCCCCCHHHHHHH		22.3125159151
145UbiquitinationPAKFALYKRCHREDQ
HHHHHHHHHHCCCCC		49.77-
180UbiquitinationPRTDTLSFVLREHEI
CCCCCEEHHEEECCC		7.2522817900
190UbiquitinationREHEIGEWEAFSLPE
EECCCCCEEECCHHH		9.3022817900
195UbiquitinationGEWEAFSLPELQNFL
CCEEECCHHHHHHHH		2.8522817900
197UbiquitinationWEAFSLPELQNFLRI
EEECCHHHHHHHHHH		69.1822817900
199UbiquitinationAFSLPELQNFLRILD
ECCHHHHHHHHHHHC		36.6524816145
205UbiquitinationLQNFLRILDKEEDEQ
HHHHHHHHCHHHHHH		6.6022817900
207UbiquitinationNFLRILDKEEDEQLQ
HHHHHHCHHHHHHHH		60.6021906983
207 (in isoform 1)Ubiquitination-60.6021906983
214UbiquitinationKEEDEQLQNLKRRYT
HHHHHHHHHHHHHHH		53.5624816145
216UbiquitinationEDEQLQNLKRRYTAY
HHHHHHHHHHHHHHH		2.7024816145
217 (in isoform 1)Ubiquitination-42.2421906983
217UbiquitinationDEQLQNLKRRYTAYR
HHHHHHHHHHHHHHH		42.2422817900
226UbiquitinationRYTAYRQKLEEALRE
HHHHHHHHHHHHHHH		49.2024816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RASF3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RASF3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RASF3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MDM2_HUMANMDM2physical
22593196
A4_HUMANAPPphysical
21832049
CDC37_HUMANCDC37physical
24366813
FGOP2_HUMANFGFR1OP2physical
24366813
MAP1B_HUMANMAP1Bphysical
24366813
MAP1S_HUMANMAP1Sphysical
24366813
STK4_HUMANSTK4physical
24366813
STK3_HUMANSTK3physical
24366813
PHOCN_HUMANMOB4physical
24366813
SIKE1_HUMANSIKE1physical
24366813
SLMAP_HUMANSLMAPphysical
24366813
STRN_HUMANSTRNphysical
24366813
STRN3_HUMANSTRN3physical
24366813
STRN4_HUMANSTRN4physical
24366813
STRP1_HUMANSTRIP1physical
24366813
VAPA_HUMANVAPAphysical
24366813
VAPB_HUMANVAPBphysical
24366813
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RASF3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-3; SER-6; SER-7AND THR-95, AND MASS SPECTROMETRY.

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