PKHH2_HUMAN - dbPTM
PKHH2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PKHH2_HUMAN
UniProt AC Q8IVE3
Protein Name Pleckstrin homology domain-containing family H member 2
Gene Name PLEKHH2
Organism Homo sapiens (Human).
Sequence Length 1493
Subcellular Localization Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane
Peripheral membrane protein
Cytoplasmic side . Cell projection, lamellipodium . Localizes to foot process of podocytes. Localization to peripheral regions of lamellipodia seems to be dependent o
Protein Description In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabilization of F-actin by attenuating its depolymerization. Can recruit TGFB1I1 from focal adhesions to podocyte lamellipodia..
Protein Sequence MAELSEPEGPVDWKERCVALESQLMKFRVQASKIRELLAEKMQQLERQVIDAERQAEKAFQQVQVMEDKLKAANIQTSESETRLYNKCQDLESLIQEKDDVIQNLELQLEEQKQIRIQEAKIIEEKAAKIKEWVTVKLNELELENQNLRLINQNQTEEIRTMQSKLQEVQGKKSSTVSTLKLSEGQRLSSLTFGCFLSRARSPPQVVKSEEMSKISSKEPEFTEGKDMEEMEIPEKSVDNQVLENNRGQRTLHQTPCGSEQNRKTRTSFATDGGISQNSGAPVSDWSSDEEDGSKGRSKSRCTSTLSSHTSEEGVQCSRMGSEMYLTASDDSSSIFEEETFGIKRPEHKKLYSWQQEAQWKALNSPLGKGNSELSKKEQDSSSDELNKKFQSQRLDYSSSSSEANTPSPILTPALMPKHPNSLSGKGTQLVPSSHLPPPKLRIPNVFSISVALAKRHLSQPQLSSDRMFGTNRNAISMIRPLRPQETDLDLVDGDSTEVLENMDTSCDDGLFSYDSLDSPNSDDQEHCDSAKKVAYSKPPTPPLHRFPSWESRIYAVAKSGIRMSEAFNMESVNKNSAATLSYTTSGLYTSLIYKNMTTPVYTTLKGKATQISSSPFLDDSSGSEEEDSSRSSSRTSESDSRSRSGPGSPRAMKRGVSLSSVASESDYAIPPDAYSTDTEYSQPEQKLPKTCSSSSDNGKNEPLEKSGYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELSASCSILRGDNKQTVQLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYSKRVWCTLIGKTLYYFRSQEDKFPLGQIKLWEAKVEEVDRSCDSDEDYEASGRSLLSTHYTIVIHPKDQGPTYLLIGSKHEKDTWLYHLTVAAGSNNVNVGSEFEQLVCKLLNIDGEPSSQIWRHPTLCHSKEGIISPLTTLPSEALQTEAIKLFKTCQLFINAAVDSPAIDYHISLAQSALQICLTHPELQNEICCQLIKQTRRRQPQNQPGPLQGWQLLALCVGLFLPHHPFLWLLRLHLKRNADSRTEFGKYAIYCQRCVERTQQNGDREARPSRMEILSTLLRNPYHHSLPFSIPVHFMNGIYQVVGFDASTTVEEFLNTLNQDTGMRKPAQSGFALFTDDPSGRDLEHCLQGNIKICDIISKWEQASKEQQPGKCEGTRTVRLTYKNRLYFSVQARGETDREKLLLMYQTNDQIINGLFPLNKDLALEMAALLSQVEIGDFERPFSTPAGHVTNQCKVNQTLKQVIEKFYPKRYRDGCSEEQLRQLCQRLSTRWMALRGHSAADCVRIYLTVARKWPFFGAKLFLAKPITPSSLGSTFLWLAVHEDGLSLLEYNSMRLIVSYVYKSLMTFGGYQDDFMVVINNTHSKDKPTEKLLFAMAKPKILEITLLIASYINNFHQQKAAFHHLSAPALLSAQTRGPQARMMGSQPLLSSSRPTKGPTLL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
22PhosphorylationERCVALESQLMKFRV
HHHHHHHHHHHHHHH		29.48-
126AcetylationEAKIIEEKAAKIKEW
HHHHHHHHHHHHHHH		40.6330591395
174PhosphorylationQEVQGKKSSTVSTLK
HHHCCCCCCCCEEEE		34.43-
175PhosphorylationEVQGKKSSTVSTLKL
HHCCCCCCCCEEEEC		41.53-
176PhosphorylationVQGKKSSTVSTLKLS
HCCCCCCCCEEEECC		26.10-
178PhosphorylationGKKSSTVSTLKLSEG
CCCCCCCEEEECCCC		28.27-
179PhosphorylationKKSSTVSTLKLSEGQ
CCCCCCEEEECCCCC		24.47-
189PhosphorylationLSEGQRLSSLTFGCF
CCCCCCHHHHHHHHH		26.0328857561
202PhosphorylationCFLSRARSPPQVVKS
HHHHCCCCCCCCCCH		39.6928985074
209PhosphorylationSPPQVVKSEEMSKIS
CCCCCCCHHHHHHHC		27.4628270605
209O-linked_GlycosylationSPPQVVKSEEMSKIS
CCCCCCCHHHHHHHC		27.4630379171
213PhosphorylationVVKSEEMSKISSKEP
CCCHHHHHHHCCCCC		30.0728270605
226MethylationEPEFTEGKDMEEMEI
CCCCCCCCCHHHCCC		47.90-
255PhosphorylationGQRTLHQTPCGSEQN
CCCCEECCCCCCCCC		15.1423898821
268PhosphorylationQNRKTRTSFATDGGI
CCCCCCCCCCCCCCC		15.03-
271PhosphorylationKTRTSFATDGGISQN
CCCCCCCCCCCCCCC		32.92-
300PhosphorylationGSKGRSKSRCTSTLS
CCCCCCHHCCCCCCC		33.56-
352PhosphorylationRPEHKKLYSWQQEAQ
CHHHHHCCCHHHHHH		19.4221945579
353PhosphorylationPEHKKLYSWQQEAQW
HHHHHCCCHHHHHHH		28.9221945579
365PhosphorylationAQWKALNSPLGKGNS
HHHHHHCCCCCCCCC		23.5028348404
388UbiquitinationSSSDELNKKFQSQRL
CCHHHHHHHHHHHCC		68.5330230243
422PhosphorylationLMPKHPNSLSGKGTQ
HCCCCCCCCCCCCCC		28.5022210691
424PhosphorylationPKHPNSLSGKGTQLV
CCCCCCCCCCCCCCC		37.9822210691
433PhosphorylationKGTQLVPSSHLPPPK
CCCCCCCHHHCCCCC		23.9428348404
434PhosphorylationGTQLVPSSHLPPPKL
CCCCCCHHHCCCCCC		23.9928348404
450PhosphorylationIPNVFSISVALAKRH
CCCCEEHHHHHHHHH		10.51-
459PhosphorylationALAKRHLSQPQLSSD
HHHHHHCCCCCCCCC		33.4228857561
471PhosphorylationSSDRMFGTNRNAISM
CCCCCCCCCHHHHHH		21.5320860994
536PhosphorylationDSAKKVAYSKPPTPP
HHHHHHHCCCCCCCC		21.8823312004
537PhosphorylationSAKKVAYSKPPTPPL
HHHHHHCCCCCCCCC		29.0222817900
541PhosphorylationVAYSKPPTPPLHRFP
HHCCCCCCCCCCCCC		46.1723312004
549PhosphorylationPPLHRFPSWESRIYA
CCCCCCCCHHHHHHH		40.5428857561
552PhosphorylationHRFPSWESRIYAVAK
CCCCCHHHHHHHHHH		20.0922817900
560PhosphorylationRIYAVAKSGIRMSEA
HHHHHHHHCCCHHHC		29.7020873877
565PhosphorylationAKSGIRMSEAFNMES
HHHCCCHHHCCCHHH		18.8720873877
572PhosphorylationSEAFNMESVNKNSAA
HHCCCHHHCCCCCCH		21.8820873877
610PhosphorylationTTLKGKATQISSSPF
EEECCEEEEECCCCC		29.8923909892
613PhosphorylationKGKATQISSSPFLDD
CCEEEEECCCCCCCC		18.2323909892
614PhosphorylationGKATQISSSPFLDDS
CEEEEECCCCCCCCC		43.5930576142
615PhosphorylationKATQISSSPFLDDSS
EEEEECCCCCCCCCC		16.9323909892
621PhosphorylationSSPFLDDSSGSEEED
CCCCCCCCCCCCCCC		35.9420363803
622PhosphorylationSPFLDDSSGSEEEDS
CCCCCCCCCCCCCCC		54.0220363803
624PhosphorylationFLDDSSGSEEEDSSR
CCCCCCCCCCCCCCC		43.7320363803
630PhosphorylationGSEEEDSSRSSSRTS
CCCCCCCCCCCCCCC		48.8030576142
632PhosphorylationEEEDSSRSSSRTSES
CCCCCCCCCCCCCCC		34.3130576142
636PhosphorylationSSRSSSRTSESDSRS
CCCCCCCCCCCCCCC		38.50-
641PhosphorylationSRTSESDSRSRSGPG
CCCCCCCCCCCCCCC		41.24-
645PhosphorylationESDSRSRSGPGSPRA
CCCCCCCCCCCCHHH		51.0622210691
649PhosphorylationRSRSGPGSPRAMKRG
CCCCCCCCHHHHHCC		17.8522210691
693PhosphorylationQKLPKTCSSSSDNGK
HCCCCCCCCCCCCCC		38.1924719451
696PhosphorylationPKTCSSSSDNGKNEP
CCCCCCCCCCCCCCC		36.7228985074
709PhosphorylationEPLEKSGYLLKMSGK
CCCHHCCEEEEECCC		18.89-
839PhosphorylationTLIGKTLYYFRSQED
ECCCCHHEEECCCCC		13.04-
840PhosphorylationLIGKTLYYFRSQEDK
CCCCHHEEECCCCCC		8.81-
866PhosphorylationKVEEVDRSCDSDEDY
HHHHHHHCCCCCCCH		20.1527794612
869PhosphorylationEVDRSCDSDEDYEAS
HHHHCCCCCCCHHHH		47.4228985074
873PhosphorylationSCDSDEDYEASGRSL
CCCCCCCHHHHCCCC		16.0228985074
1208PhosphorylationQPGKCEGTRTVRLTY
CCCCCCCCEEEEEEE		10.81-
1222PhosphorylationYKNRLYFSVQARGET
ECCEEEEEEEECCCC		10.36-
1300PhosphorylationKQVIEKFYPKRYRDG
HHHHHHHCCHHHCCC		20.93-
1399PhosphorylationYVYKSLMTFGGYQDD
HHHHHHHHCCCCCCC		25.15-
1421PhosphorylationTHSKDKPTEKLLFAM
CCCCCCCCHHHHHHH		52.04-
1458PhosphorylationKAAFHHLSAPALLSA
HHHHHHCCHHHHHCC		28.0526657352
1477PhosphorylationPQARMMGSQPLLSSS
HHHHHCCCCCCCCCC		15.6628857561
1482PhosphorylationMGSQPLLSSSRPTKG
CCCCCCCCCCCCCCC		33.6724719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PKHH2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PKHH2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PKHH2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PKHH2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PKHH2_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory