dbPTM

MTSS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MTSS1_HUMAN
UniProt AC	O43312
Protein Name	Metastasis suppressor protein 1
Gene Name	MTSS1
Organism	Homo sapiens (Human).
Sequence Length	755
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton..
Protein Sequence	MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	ATNTRGGTREIGSAL HCCCCCCHHHHHHHH	28.14	22210691
141	Phosphorylation	RQEIKKKSSDTLKLQ HHHHHHHCCHHHHHH	42.18	28060719
142	Phosphorylation	QEIKKKSSDTLKLQK HHHHHHCCHHHHHHH	43.42	28060719
144	Phosphorylation	IKKKSSDTLKLQKKA HHHHCCHHHHHHHHH	27.95	25849741
146	Acetylation	KKSSDTLKLQKKAKK HHCCHHHHHHHHHHC	51.47	12656435
149	Acetylation	SDTLKLQKKAKKGRG CHHHHHHHHHHCCCC	66.20	12656445
150	Acetylation	DTLKLQKKAKKGRGD HHHHHHHHHHCCCCC	53.10	12656455
250	Phosphorylation	VILDLKGSDYSWSYQ EEEECCCCCCEEECC	31.61	28060719
252	Phosphorylation	LDLKGSDYSWSYQTP EECCCCCCEEECCCC	17.46	28060719
253	Phosphorylation	DLKGSDYSWSYQTPP ECCCCCCEEECCCCC	17.97	22199227
255	Phosphorylation	KGSDYSWSYQTPPSS CCCCCEEECCCCCCC	11.04	23663014
256	Phosphorylation	GSDYSWSYQTPPSSP CCCCEEECCCCCCCC	15.33	29970186
258	Phosphorylation	DYSWSYQTPPSSPST CCEEECCCCCCCCCC	29.00	22617229
261	Phosphorylation	WSYQTPPSSPSTTMS EECCCCCCCCCCCCC	56.96	22617229
262	Phosphorylation	SYQTPPSSPSTTMSR ECCCCCCCCCCCCCC	28.75	22617229
264	Phosphorylation	QTPPSSPSTTMSRKS CCCCCCCCCCCCCHH	38.16	22199227
265	Phosphorylation	TPPSSPSTTMSRKSS CCCCCCCCCCCCHHH	29.87	22199227
266	Phosphorylation	PPSSPSTTMSRKSSV CCCCCCCCCCCHHHH	19.93	22199227
268	Phosphorylation	SSPSTTMSRKSSVCS CCCCCCCCCHHHHHH	34.17	22199227
271	Phosphorylation	STTMSRKSSVCSSLN CCCCCCHHHHHHHCC	27.22	23401153
272	Phosphorylation	TTMSRKSSVCSSLNS CCCCCHHHHHHHCCC	30.12	23401153
275	Phosphorylation	SRKSSVCSSLNSVNS CCHHHHHHHCCCCCC	35.39	28450419
276	Phosphorylation	RKSSVCSSLNSVNSS CHHHHHHHCCCCCCC	26.83	28450419
279	Phosphorylation	SVCSSLNSVNSSDSR HHHHHCCCCCCCCCC	28.15	28450419
285	Phosphorylation	NSVNSSDSRSSGSHS CCCCCCCCCCCCCCC	35.69	30576142
287	Phosphorylation	VNSSDSRSSGSHSHS CCCCCCCCCCCCCCC	42.90	30576142
288	Phosphorylation	NSSDSRSSGSHSHSP CCCCCCCCCCCCCCC	43.11	22468782
290	Phosphorylation	SDSRSSGSHSHSPSS CCCCCCCCCCCCCCC	24.62	22468782
292	Phosphorylation	SRSSGSHSHSPSSHY CCCCCCCCCCCCCCC	27.62	30576142
294	Phosphorylation	SSGSHSHSPSSHYRY CCCCCCCCCCCCCCC	29.50	28270605
296	Phosphorylation	GSHSHSPSSHYRYRS CCCCCCCCCCCCCCC	32.53	28270605
297	Phosphorylation	SHSHSPSSHYRYRSS CCCCCCCCCCCCCCC	28.11	23312004
299	Phosphorylation	SHSPSSHYRYRSSNL CCCCCCCCCCCCCCH	15.99	23312004
315	Phosphorylation	QQAPVRLSSVSSHDS HHCCEEHHHCCCCCC	20.37	28450419
316	Phosphorylation	QAPVRLSSVSSHDSG HCCEEHHHCCCCCCC	30.52	23401153
318	Phosphorylation	PVRLSSVSSHDSGFI CEEHHHCCCCCCCCC	24.73	28450419
319	Phosphorylation	VRLSSVSSHDSGFIS EEHHHCCCCCCCCCC	29.20	28450419
322	Phosphorylation	SSVSSHDSGFISQDA HHCCCCCCCCCCHHH	30.13	28450419
383	Phosphorylation	SRLLPRVTSVHLPDY HHHHCCEEEEECCCC	26.72	22115753
384	Phosphorylation	RLLPRVTSVHLPDYA HHHCCEEEEECCCCC	12.51	22115753
390	Phosphorylation	TSVHLPDYAHYYTIG EEEECCCCCCEEEEC	8.04	27259358
393	Phosphorylation	HLPDYAHYYTIGPGM ECCCCCCEEEECCCC	8.30	27259358
394	Phosphorylation	LPDYAHYYTIGPGMF CCCCCCEEEECCCCC	5.08	22817900
418	Phosphorylation	DWAKPGPYDQPLVNT CCCCCCCCCCHHHHH	32.88	-
425	Phosphorylation	YDQPLVNTLQRRKEK CCCHHHHHHHHHHHH	19.45	25850435
444	Phosphorylation	PNGGGPTTASGPPAA CCCCCCCCCCCCCHH	23.20	22210691
446	Phosphorylation	GGGPTTASGPPAAAE CCCCCCCCCCCHHHH	50.14	22210691
460	Phosphorylation	EEAQRPRSMTVSAAT HHHCCCCCEEEECCC	22.84	22210691
484	Phosphorylation	EELALALSRGLQLDT HHHHHHHHHCCCCCC	20.78	24719451
491	Phosphorylation	SRGLQLDTQRSSRDS HHCCCCCCCCCCCCC	34.18	27251275
494	Phosphorylation	LQLDTQRSSRDSLQC CCCCCCCCCCCCCCC	21.65	27251275
495	Phosphorylation	QLDTQRSSRDSLQCS CCCCCCCCCCCCCCC	42.15	27251275
545	Phosphorylation	DQQEFDKSSTIPRNS HHHHHCCCCCCCCCC	34.26	22210691
547	Phosphorylation	QEFDKSSTIPRNSDI HHHCCCCCCCCCCCC	41.93	22210691
555	Phosphorylation	IPRNSDISQSYRRMF CCCCCCCCHHHHHHH	20.33	22210691
557	Phosphorylation	RNSDISQSYRRMFQA CCCCCCHHHHHHHHC	17.51	27251275
569	Phosphorylation	FQAKRPASTAGLPTT HHCCCCCCCCCCCCC	22.82	28857561
570	Phosphorylation	QAKRPASTAGLPTTL HCCCCCCCCCCCCCC	27.18	23403867
575	Phosphorylation	ASTAGLPTTLGPAMV CCCCCCCCCCCCCCC	39.43	28857561
576	Phosphorylation	STAGLPTTLGPAMVT CCCCCCCCCCCCCCC	27.98	28857561
583	Phosphorylation	TLGPAMVTPGVATIR CCCCCCCCCCEEEEE	10.97	22468782
588	Phosphorylation	MVTPGVATIRRTPST CCCCCEEEEECCCCC	16.77	28060719
592	Phosphorylation	GVATIRRTPSTKPSV CEEEEECCCCCCCCC	16.25	23403867
594	Phosphorylation	ATIRRTPSTKPSVRR EEEECCCCCCCCCCC	48.74	23401153
595	Phosphorylation	TIRRTPSTKPSVRRG EEECCCCCCCCCCCC	48.45	23403867
596	Acetylation	IRRTPSTKPSVRRGT EECCCCCCCCCCCCC	39.36	7672025
598	Phosphorylation	RTPSTKPSVRRGTIG CCCCCCCCCCCCCCC	29.79	23403867
603	Phosphorylation	KPSVRRGTIGAGPIP CCCCCCCCCCCCCCC	17.90	28857561
613	Phosphorylation	AGPIPIKTPVIPVKT CCCCCCCCCCEECCC	24.41	24719451
620	Phosphorylation	TPVIPVKTPTVPDLP CCCEECCCCCCCCCC	25.15	28348404
622	Phosphorylation	VIPVKTPTVPDLPGV CEECCCCCCCCCCCC	50.32	28348404
644	Phosphorylation	PEERGEHSPESPSVG CHHCCCCCCCCCCCC	26.51	20058876
647	Phosphorylation	RGEHSPESPSVGEGP CCCCCCCCCCCCCCC	26.34	28270605
649	Phosphorylation	EHSPESPSVGEGPQG CCCCCCCCCCCCCCC	52.62	20058876
658	Phosphorylation	GEGPQGVTSMPSSMW CCCCCCCCCCCCHHC	26.57	28270605
659	Phosphorylation	EGPQGVTSMPSSMWS CCCCCCCCCCCHHCC	26.70	28270605
662	Phosphorylation	QGVTSMPSSMWSGQA CCCCCCCCHHCCCCC	24.96	28270605
663	Phosphorylation	GVTSMPSSMWSGQAS CCCCCCCHHCCCCCC	20.57	28270605
666	Phosphorylation	SMPSSMWSGQASVNP CCCCHHCCCCCCCCC	16.64	28270605
670	Phosphorylation	SMWSGQASVNPPLPG HHCCCCCCCCCCCCC	17.97	28270605
693	Phosphorylation	HRQAIPESEAEDQER HHHHCCHHHHHHCCC	36.43	28060719
721	Phosphorylation	ESDPADLSPRDTPQG CCCCCCCCCCCCCCC	20.59	28060719

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
322	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MTSS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MTSS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SKP1_HUMAN	SKP1	physical	24318128
KC1D_HUMAN	CSNK1D	physical	24318128

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MTSS1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-258 AND SER-261, ANDMASS SPECTROMETRY.	18088087 [Abstract]