FOXN2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXN2_HUMAN
• UniProt AC: P32314
• Protein Name: Forkhead box protein N2
• Gene Name: FOXN2
• Organism: Homo sapiens (Human).
• Sequence Length: 431
• Subcellular Localization: Nucleus.
• Protein Description: Binds to the purine-rich region in HTLV-I LTR..
• Protein Sequence: MGPVIGMTPDKRAETPGAEKIAGLSQIYKMGSLPEAVDAARPKATLVDSESADDELTNLNWLHESTNLLTNFSLGSEGLPIVSPLYDIEGDDVPSFGPACYQNPEKKSATSKPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILDHFPYFATAPTGWKNSVRHNLSLNKCFQKVERSHGKVNGKGSLWCVDPEYKPNLIQALKKQPFSSASSQNGSLSPHYLSSVIKQNQVRNLKESDIDAAAAMMLLNTSIEQGILECEKPLPLKTALQKKRSYGNAFHHPSAVRLQESDSLATSIDPKEDHNYSASSMAAQRCASRSSVSSLSSVDEVYEFIPKNSHVGSDGSEGFHSEEDTDVDYEDDPLGDSGYASQPCAKISEKGQSGKKMRKQTCQEIDEELKEAAGSLLHLAGIRTCLGSLISTAKTQNQKQRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGPVIGMTPDKRAET CCCCCCCCCCCCCCC	24.11	-
15	Phosphorylation	TPDKRAETPGAEKIA CCCCCCCCCCHHHHH	26.49	-
28	Phosphorylation	IAGLSQIYKMGSLPE HHCHHHHHHCCCCHH	6.31	-
115	Phosphorylation	SATSKPPYSFSLLIY CCCCCCCCCHHHHHH	30.76	24719451
118	Phosphorylation	SKPPYSFSLLIYMAI CCCCCCHHHHHHHHH	19.14	24719451
122	Phosphorylation	YSFSLLIYMAIEHSP CCHHHHHHHHHHCCC	4.77	-
128	Phosphorylation	IYMAIEHSPNKCLPV HHHHHHCCCCCEECH	19.85	24719451
165	Phosphorylation	NSVRHNLSLNKCFQK HHHHHHCHHHHHHHH	34.90	21712546
168	Ubiquitination	RHNLSLNKCFQKVER HHHCHHHHHHHHHHH	41.54	29967540
207	Phosphorylation	ALKKQPFSSASSQNG HHHHCCCCCCCCCCC	31.51	28450419
208	Phosphorylation	LKKQPFSSASSQNGS HHHCCCCCCCCCCCC	32.33	28450419
210	Phosphorylation	KQPFSSASSQNGSLS HCCCCCCCCCCCCCC	34.11	28450419
211	Phosphorylation	QPFSSASSQNGSLSP CCCCCCCCCCCCCCH	27.64	28450419
215	Phosphorylation	SASSQNGSLSPHYLS CCCCCCCCCCHHHHH	32.97	28450419
217	Phosphorylation	SSQNGSLSPHYLSSV CCCCCCCCHHHHHHH	16.01	28450419
220	Phosphorylation	NGSLSPHYLSSVIKQ CCCCCHHHHHHHHHH	16.21	28450419
222	Phosphorylation	SLSPHYLSSVIKQNQ CCCHHHHHHHHHHHH	18.52	28450419
223	Phosphorylation	LSPHYLSSVIKQNQV CCHHHHHHHHHHHHH	25.85	28450419
273	Phosphorylation	TALQKKRSYGNAFHH HHHHHHHCCCCCCCC	46.39	22496350
274	Phosphorylation	ALQKKRSYGNAFHHP HHHHHHCCCCCCCCC	20.59	29978859
318	Phosphorylation	AQRCASRSSVSSLSS HHHHHHCCCCCCCCC	32.37	-
330	Phosphorylation	LSSVDEVYEFIPKNS CCCHHHHHHCCCCCC	11.77	-
365	Phosphorylation	EDDPLGDSGYASQPC CCCCCCCCCCCCCCC	31.72	-
369	Phosphorylation	LGDSGYASQPCAKIS CCCCCCCCCCCHHHH	26.60	-
416	Phosphorylation	GIRTCLGSLISTAKT HHHHHHHHHHHHHHH	15.02	-
422	Ubiquitination	GSLISTAKTQNQKQR HHHHHHHHHHCHHHH	51.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
365	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS
369	S	Phosphorylation	Kinase	RPS6KA3	P51812	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXN2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXN2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBP7_HUMAN	USP7	physical	21845734
RFX1_HUMAN	RFX1	physical	25609649
FBW1B_HUMAN	FBXW11	physical	25609649
HCFC1_HUMAN	HCFC1	physical	25609649
SKP1_HUMAN	SKP1	physical	25609649
FBW1A_HUMAN	BTRC	physical	25609649
PSMD8_HUMAN	PSMD8	physical	25609649
RFX1_HUMAN	RFX1	physical	28514442
RFX2_HUMAN	RFX2	physical	28514442
FBW1A_HUMAN	BTRC	physical	28514442
FBW1B_HUMAN	FBXW11	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.