DJB14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DJB14_HUMAN
• UniProt AC: Q8TBM8
• Protein Name: DnaJ homolog subfamily B member 14 {ECO:0000312|HGNC:HGNC:25881}
• Gene Name: DNAJB14 {ECO:0000312|HGNC:HGNC:25881}
• Organism: Homo sapiens (Human).
• Sequence Length: 379
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass membrane protein . Nucleus membrane ; Single-pass membrane protein . Localizes to the endoplasmic reticulum membrane (PubMed:23018488, PubMed:24732912, PubMed:27916661). When overexpressed, forms membranou
• Protein Description: Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway. [PubMed: 24732912 Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities]
• Protein Sequence: MEGNRDEAEKCVEIAREALNAGNREKAQRFLQKAEKLYPLPSARALLEIIMKNGSTAGNSPHCRKPSGSGDQSKPNCTKDSTSGSGEGGKGYTKDQVDGVLSINKCKNYYEVLGVTKDAGDEDLKKAYRKLALKFHPDKNHAPGATDAFKKIGNAYAVLSNPEKRKQYDLTGNEEQACNHQNNGRFNFHRGCEADITPEDLFNIFFGGGFPSGSVHSFSNGRAGYSQQHQHRHSGHEREEERGDGGFSVFIQLMPIIVLILVSLLSQLMVSNPPYSLYPRSGTGQTIKMQTENLGVVYYVNKDFKNEYKGMLLQKVEKSVEEDYVTNIRNNCWKERQQKTDMQYAAKVYRDDRLRRKADALSMDNCKELERLTSLYKGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16 (in isoform 2)	Phosphorylation	-	35.07	26503514
24 (in isoform 2)	Phosphorylation	-	45.97	26503514
25 (in isoform 2)	Phosphorylation	-	57.66	26503514
38	Phosphorylation	LQKAEKLYPLPSARA HHHHHHHCCCHHHHH	17.50	29523821
42	Phosphorylation	EKLYPLPSARALLEI HHHCCCHHHHHHHHH	37.76	29523821
55	Phosphorylation	EIIMKNGSTAGNSPH HHHHHCCCCCCCCCC	25.20	23882029
56	Phosphorylation	IIMKNGSTAGNSPHC HHHHCCCCCCCCCCC	39.73	23882029
60	Phosphorylation	NGSTAGNSPHCRKPS CCCCCCCCCCCCCCC	18.33	25849741
67	Phosphorylation	SPHCRKPSGSGDQSK CCCCCCCCCCCCCCC	48.93	23882029
69	Phosphorylation	HCRKPSGSGDQSKPN CCCCCCCCCCCCCCC	43.46	26657352
73	Phosphorylation	PSGSGDQSKPNCTKD CCCCCCCCCCCCCCC	55.62	29978859
78	Phosphorylation	DQSKPNCTKDSTSGS CCCCCCCCCCCCCCC	44.52	26074081
94	Ubiquitination	EGGKGYTKDQVDGVL CCCCCCCHHHHCEEE	37.37	-
105	Ubiquitination	DGVLSINKCKNYYEV CEEEEECCCCCCHHH	44.94	-
110	Phosphorylation	INKCKNYYEVLGVTK ECCCCCCHHHHCEEC	14.68	27642862
117	Ubiquitination	YEVLGVTKDAGDEDL HHHHCEECCCCCHHH	43.08	-
134	Ubiquitination	AYRKLALKFHPDKNH HHHHHHHHHCCCCCC	35.70	-
139	Ubiquitination	ALKFHPDKNHAPGAT HHHHCCCCCCCCCHH	55.90	21906983
150	Ubiquitination	PGATDAFKKIGNAYA CCHHHHHHHHHHEEH	45.24	-
156	Phosphorylation	FKKIGNAYAVLSNPE HHHHHHEEHHHCCHH	10.97	27732954
160	Phosphorylation	GNAYAVLSNPEKRKQ HHEEHHHCCHHHHHC	43.68	27732954
164	Ubiquitination	AVLSNPEKRKQYDLT HHHCCHHHHHCCCCC	67.18	-
166	Ubiquitination	LSNPEKRKQYDLTGN HCCHHHHHCCCCCCC	65.36	-
309	Ubiquitination	KDFKNEYKGMLLQKV CCCCHHHHHHHHHHH	31.50	-
318	Ubiquitination	MLLQKVEKSVEEDYV HHHHHHHHHHHHHHH	63.89	-
319	Phosphorylation	LLQKVEKSVEEDYVT HHHHHHHHHHHHHHH	22.66	26270265
324	Phosphorylation	EKSVEEDYVTNIRNN HHHHHHHHHHHHHHH	16.68	26270265
326	Phosphorylation	SVEEDYVTNIRNNCW HHHHHHHHHHHHHCH	20.78	26270265
327	N-linked_Glycosylation	VEEDYVTNIRNNCWK HHHHHHHHHHHHCHH	22.60	-
327	N-linked_Glycosylation	VEEDYVTNIRNNCWK HHHHHHHHHHHHCHH	22.60	19349973
347	Ubiquitination	TDMQYAAKVYRDDRL CHHHHHHHHHHHHHH	31.46	-
357	Ubiquitination	RDDRLRRKADALSMD HHHHHHHHHHHHCCC	44.15	-
367	Ubiquitination	ALSMDNCKELERLTS HHCCCCHHHHHHHHH	72.14	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DJB14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DJB14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DJB14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP7C_HUMAN	HSPA8	physical	23018488
A4_HUMAN	APP	physical	21832049
HSP72_HUMAN	HSPA2	physical	26344197
HSP7C_HUMAN	HSPA8	physical	26344197
GRP75_HUMAN	HSPA9	physical	26344197
KHK_HUMAN	KHK	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.