dbPTM

CRML_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CRML_HUMAN
UniProt AC	Q96RY5
Protein Name	Protein cramped-like {ECO:0000305}
Gene Name	CRAMP1 {ECO:0000312\|HGNC:HGNC:14122}
Organism	Homo sapiens (Human).
Sequence Length	1269
Subcellular Localization	Nucleus .
Protein Description
Protein Sequence	MTVKLGDGGSGEDGLKKLGKRAADEESLEGEGAGGADAAEESSGTKRDEKTPRAGADGPPAPPGAPQAPSPPQGSPQDQHHFLRSSVRPQSKRPRKDPPSAVGSGNAGGSGPRGKGAEGGGSSSGNVSGVAPAAPAGGSRSSSRNLGSSGGEKEEGKKVRRQWESWSTEDKNTFFEGLYEHGKDFEAIQNNIALKYKKKGKPASMVKNKEQVRHFYYRTWHKITKYIDFDHVFSRGLKKSSQELYGLICYGELRKKIGGCMDDKNATKLNELIQVGATTVRYKGRNLRIKAPMCRALKKLCDPDGLSDEEDQKPVRLPLKVPIELQPRNNHAWARVQSLAQNPRLRMIVELHRKVSSLIEFLKQKWALHEVRVRKTLEERQLQDSCSAPMQEKVTLHLFPGENCTLTPLPGVARVVHSKAFCTVHWQEGGRCKQSAKDAHVLPPAQILGIQSGQGTARGQVKCPRSGAEGKGVGRPPPAADALQSSGESSPESAPGEGAALSLSSPDAPDRPPPRHQDTGPCLEKTPAEGRDSPTREPGALPCACGQLPDLEDELSLLDPLPRYLKSCQDLIVPEQCRCADTRPGSEQPPLGGAASPEVLAPVSKEAADLAPTGPSPRPGPGLLLDVCTKDLADAPAEELQEKGSPAGPPPSQGQPAARPPKEVPASRLAQQLREEGWNLQTSESLTLAEVYLMMGKPSKLQLEYDWLGPGRQDPRPGSLPTALHKQRLLSCLLKLISTEVNPKLALEANTISTASVRPAQEEQSMTPPGKVVTVSSRSPRCPRNQASLRSSKTFPPSSAPCSSGLRNPPRPLLVPGPSSTGSNDSDGGLFAVPTTLPPNSRHGKLFSPSKEAELTFRQHLNSISMQSDFFLPKPRKLRNRHLRKPLVVQRTLLPRPSENQSHNVCSFSILSNSSVTGRGSFRPIQSSLTKAALSRPIVPKVLPPQATSHLASAIDLAATSAGILSGNPLPALDTEGLSGISPLSSDEVTGAISGQDSTGTHQDGDTLPTVGGSDPFVSIPSRPEQEPVADSFQGSSVLSLSELPKAPLQNGLSIPLSSSESSSTRLSPPDVSALLDISLPGPPEDALSQGEPATHISDSIIEIAISSGQYGEGVPLSPAKLNGSDSSKSLPSPSSSPQPHWIASPTHDPQWYPSDSTDSSLSSLFASFISPEKSRKMLPTPIGTNSGTSLLGPSLLDGNSRDSFVSRSLADVAEVVDSQLVCMMNENSIDYISRFNDLAQELSIAEPGRREALFDGGGGGPAVSDLSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Acetylation	GSGEDGLKKLGKRAA CCCHHHHHHHHHHHC	52.02	25953088
20	Ubiquitination	DGLKKLGKRAADEES HHHHHHHHHHCCHHH	49.66	-
27	Phosphorylation	KRAADEESLEGEGAG HHHCCHHHHCCCCCC	29.67	28985074
70	Phosphorylation	PGAPQAPSPPQGSPQ CCCCCCCCCCCCCCC	52.83	23401153
75	Phosphorylation	APSPPQGSPQDQHHF CCCCCCCCCCHHHHH	17.72	25159151
91	Phosphorylation	RSSVRPQSKRPRKDP HHCCCCCCCCCCCCC	33.06	26657352
100	Phosphorylation	RPRKDPPSAVGSGNA CCCCCCCCCCCCCCC	40.76	25954137
104	Phosphorylation	DPPSAVGSGNAGGSG CCCCCCCCCCCCCCC	23.44	25159151
110	Phosphorylation	GSGNAGGSGPRGKGA CCCCCCCCCCCCCCC	44.71	25627689
122	Phosphorylation	KGAEGGGSSSGNVSG CCCCCCCCCCCCCCC	25.30	25954137
123	Phosphorylation	GAEGGGSSSGNVSGV CCCCCCCCCCCCCCC	45.60	25954137
124	Phosphorylation	AEGGGSSSGNVSGVA CCCCCCCCCCCCCCC	35.76	25954137
128	Phosphorylation	GSSSGNVSGVAPAAP CCCCCCCCCCCCCCC	31.39	25954137
139	Phosphorylation	PAAPAGGSRSSSRNL CCCCCCCCCCCCCCC	28.24	25954137
165	Phosphorylation	KVRRQWESWSTEDKN HHHHHHHHCCCCCCC	24.30	28634298
167	Phosphorylation	RRQWESWSTEDKNTF HHHHHHCCCCCCCCH	31.06	28634298
168	Phosphorylation	RQWESWSTEDKNTFF HHHHHCCCCCCCCHH	41.78	28634298
179	Phosphorylation	NTFFEGLYEHGKDFE CCHHHHHHHCCCCHH	19.41	-
195	Ubiquitination	IQNNIALKYKKKGKP HHHHHHHHHHHCCCC	46.10	-
245	Phosphorylation	KKSSQELYGLICYGE CCHHHHHHHHHHHHH	14.77	29083192
250	Phosphorylation	ELYGLICYGELRKKI HHHHHHHHHHHHHHH	13.47	29083192
267	Phosphorylation	CMDDKNATKLNELIQ CCCCCCCHHHHHHHH	45.52	-
307	Phosphorylation	LCDPDGLSDEEDQKP HCCCCCCCCCCCCCC	48.80	23401153
338	Phosphorylation	HAWARVQSLAQNPRL CHHHHHHHHHHCHHH	23.86	26552605
363	Ubiquitination	SSLIEFLKQKWALHE HHHHHHHHHHHHHHH	55.97	-
365	Ubiquitination	LIEFLKQKWALHEVR HHHHHHHHHHHHHHH	32.61	-
493	Phosphorylation	SGESSPESAPGEGAA CCCCCCCCCCCCCCC	43.05	-
526	Phosphorylation	TGPCLEKTPAEGRDS CCCCCCCCCCCCCCC	20.53	26074081
530	Phosphorylation	LEKTPAEGRDSPTRE CCCCCCCCCCCCCCC	40.58	18220336
532	Phosphorylation	KTPAEGRDSPTREPG CCCCCCCCCCCCCCC	70.58	18220336
533	Phosphorylation	TPAEGRDSPTREPGA CCCCCCCCCCCCCCC	27.15	25159151
535	Phosphorylation	AEGRDSPTREPGALP CCCCCCCCCCCCCCC	52.17	25159151
556	Phosphorylation	PDLEDELSLLDPLPR CCHHHHHHHHCCHHH	25.49	27251275
564	Phosphorylation	LLDPLPRYLKSCQDL HHCCHHHHHHHCHHC	19.28	20068231
567	Phosphorylation	PLPRYLKSCQDLIVP CHHHHHHHCHHCCCC	17.89	20068231
582	Phosphorylation	EQCRCADTRPGSEQP CCCCCCCCCCCCCCC	21.90	26074081
586	Phosphorylation	CADTRPGSEQPPLGG CCCCCCCCCCCCCCC	35.42	26074081
596	Phosphorylation	PPLGGAASPEVLAPV CCCCCCCCHHHHHCC	22.51	23401153
604	Phosphorylation	PEVLAPVSKEAADLA HHHHHCCCHHHHHHC	24.58	26074081
613	Phosphorylation	EAADLAPTGPSPRPG HHHHHCCCCCCCCCC	57.00	26074081
616	Phosphorylation	DLAPTGPSPRPGPGL HHCCCCCCCCCCCCE	34.58	25159151
629	Phosphorylation	GLLLDVCTKDLADAP CEEEEEHHHHHCCCC	27.69	26074081
645	Phosphorylation	EELQEKGSPAGPPPS HHHHHCCCCCCCCCC	23.73	23401153
652	Phosphorylation	SPAGPPPSQGQPAAR CCCCCCCCCCCCCCC	53.36	26074081
719	Phosphorylation	RQDPRPGSLPTALHK CCCCCCCCCCHHHHH	33.58	-
744	Methylation	ISTEVNPKLALEANT HHCCCCHHHHHHCCC	40.98	-
744	"N6,N6-dimethyllysine"	ISTEVNPKLALEANT HHCCCCHHHHHHCCC	40.98	-
753	Phosphorylation	ALEANTISTASVRPA HHHCCCCEECCCCCC	18.84	28348404
754	Phosphorylation	LEANTISTASVRPAQ HHCCCCEECCCCCCH	21.07	28348404
756	Phosphorylation	ANTISTASVRPAQEE CCCCEECCCCCCHHC	20.81	25627689
765	Phosphorylation	RPAQEEQSMTPPGKV CCCHHCCCCCCCCEE	28.09	27732954
767	Phosphorylation	AQEEQSMTPPGKVVT CHHCCCCCCCCEEEE	31.42	30576142
774	Phosphorylation	TPPGKVVTVSSRSPR CCCCEEEEECCCCCC	20.05	23403867
776	Phosphorylation	PGKVVTVSSRSPRCP CCEEEEECCCCCCCC	15.63	23403867
777	Phosphorylation	GKVVTVSSRSPRCPR CEEEEECCCCCCCCC	32.23	23403867
779	Phosphorylation	VVTVSSRSPRCPRNQ EEEECCCCCCCCCCH	20.74	23898821
791	Phosphorylation	RNQASLRSSKTFPPS CCHHHHCCCCCCCCC	41.29	-
845	Acetylation	PPNSRHGKLFSPSKE CCCCCCCCCCCCCHH	39.99	25953088
845	Phosphorylation	PPNSRHGKLFSPSKE CCCCCCCCCCCCCHH	39.99	18669648
848	Phosphorylation	SRHGKLFSPSKEAEL CCCCCCCCCCHHHHH	38.41	30266825
850	Phosphorylation	HGKLFSPSKEAELTF CCCCCCCCHHHHHHH	41.76	30266825
856	Phosphorylation	PSKEAELTFRQHLNS CCHHHHHHHHHHHHH	14.31	30266825
865	Phosphorylation	RQHLNSISMQSDFFL HHHHHHHCCCCCCCC	15.58	20068231
1060	Phosphorylation	LSIPLSSSESSSTRL CCCCCCCCCCCCCCC	37.81	30576142
1063	Phosphorylation	PLSSSESSSTRLSPP CCCCCCCCCCCCCCC	31.51	30576142
1118	Phosphorylation	YGEGVPLSPAKLNGS CCCCCCCCCCCCCCC	19.42	24719451
1133	Phosphorylation	DSSKSLPSPSSSPQP CCCCCCCCCCCCCCC	42.58	30576142
1136	Phosphorylation	KSLPSPSSSPQPHWI CCCCCCCCCCCCCEE	49.80	30576142
1145	Phosphorylation	PQPHWIASPTHDPQW CCCCEEECCCCCCCC	22.62	30576142
1185	Phosphorylation	MLPTPIGTNSGTSLL CCCCCCCCCCCCCCC	27.25	30301811
1187	Phosphorylation	PTPIGTNSGTSLLGP CCCCCCCCCCCCCCH	43.20	22115753
1189	Phosphorylation	PIGTNSGTSLLGPSL CCCCCCCCCCCCHHH	18.93	28450419
1190	Phosphorylation	IGTNSGTSLLGPSLL CCCCCCCCCCCHHHC	25.73	28450419
1195	Phosphorylation	GTSLLGPSLLDGNSR CCCCCCHHHCCCCCC	39.50	29255136
1201	Phosphorylation	PSLLDGNSRDSFVSR HHHCCCCCCHHHHHH	42.89	29255136
1204	Phosphorylation	LDGNSRDSFVSRSLA CCCCCCHHHHHHHHH	26.83	28450419
1207	Phosphorylation	NSRDSFVSRSLADVA CCCHHHHHHHHHHHH	17.72	28450419
1229	Phosphorylation	VCMMNENSIDYISRF HECCCCCCHHHHHHH	15.62	26074081
1232	Phosphorylation	MNENSIDYISRFNDL CCCCCHHHHHHHHHH	10.10	27732954
1234	Phosphorylation	ENSIDYISRFNDLAQ CCCHHHHHHHHHHHH	25.29	27732954
1244	Phosphorylation	NDLAQELSIAEPGRR HHHHHHHCCCCCCCC	20.99	28555341
1265	Phosphorylation	GGGGPAVSDLSQ--- CCCCCCCHHCCC---	34.63	23663014
1268	Phosphorylation	GPAVSDLSQ------ CCCCHHCCC------	38.54	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CRML_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CRML_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CRML_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GON4L_HUMAN	GON4L	physical	28514442
NPAT_HUMAN	NPAT	physical	28514442
P4R3B_HUMAN	SMEK2	physical	28514442
S18L2_HUMAN	SS18L2	physical	28514442
UBP20_HUMAN	USP20	physical	28514442
P4R3A_HUMAN	SMEK1	physical	28514442
PP4R2_HUMAN	PPP4R2	physical	28514442
AKA11_HUMAN	AKAP11	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CRML_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1268, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-533, AND MASSSPECTROMETRY.	18220336 [Abstract]