ZN436_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN436_HUMAN
• UniProt AC: Q9C0F3
• Protein Name: Zinc finger protein 436
• Gene Name: ZNF436
• Organism: Homo sapiens (Human).
• Sequence Length: 470
• Subcellular Localization: Nucleus .
• Protein Description: May be a transcriptional repressor..
• Protein Sequence: MAATLLMAGSQAPVTFEDMAMYLTREEWRPLDAAQRDLYRDVMQENYGNVVSLDFEIRSENEVNPKQEISEDVQFGTTSERPAENAEENPESEEGFESGDRSERQWGDLTAEEWVSYPLQPVTDLLVHKEVHTGIRYHICSHCGKAFSQISDLNRHQKTHTGDRPYKCYECGKGFSRSSHLIQHQRTHTGERPYDCNECGKSFGRSSHLIQHQTIHTGEKPHKCNECGKSFCRLSHLIQHQRTHSGEKPYECEECGKSFSRSSHLAQHQRTHTGEKPYECNECGRGFSERSDLIKHYRVHTGERPYKCDECGKNFSQNSDLVRHRRAHTGEKPYHCNECGENFSRISHLVQHQRTHTGEKPYECNACGKSFSRSSHLITHQKIHTGEKPYECNECWRSFGERSDLIKHQRTHTGEKPYECVQCGKGFTQSSNLITHQRVHTGEKPYECTECEKSFSRSSALIKHKRVHTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAATLLMAGSQ ----CCCCHHCCCCC	15.75	23532336
10	Phosphorylation	ATLLMAGSQAPVTFE CCHHCCCCCCCCCHH	17.40	23663014
15	Phosphorylation	AGSQAPVTFEDMAMY CCCCCCCCHHHHHHH	21.90	23663014
22	Phosphorylation	TFEDMAMYLTREEWR CHHHHHHHHHHHHHC	8.72	23663014
24	Phosphorylation	EDMAMYLTREEWRPL HHHHHHHHHHHHCCC	20.67	23663014
66	Sumoylation	SENEVNPKQEISEDV CCCCCCCCHHHCCCC	56.19	28112733
92	Phosphorylation	NAEENPESEEGFESG CCCCCCCCCCCCCCC	42.05	28985074
167	Sumoylation	HTGDRPYKCYECGKG CCCCCCEEEEECCCC	32.78	-
167	Sumoylation	HTGDRPYKCYECGKG CCCCCCEEEEECCCC	32.78	-
243	Phosphorylation	HLIQHQRTHSGEKPY HHHHHCCCCCCCCCC	17.52	-
245	Phosphorylation	IQHQRTHSGEKPYEC HHHCCCCCCCCCCCC	48.29	-
260	Phosphorylation	EECGKSFSRSSHLAQ HHHCCCCCCHHHHHH	38.04	17081983
271	Phosphorylation	HLAQHQRTHTGEKPY HHHHHCCCCCCCCCC	19.74	-
273	Phosphorylation	AQHQRTHTGEKPYEC HHHCCCCCCCCCCCC	46.56	-
301	Phosphorylation	IKHYRVHTGERPYKC HHHCEECCCCCCCCC	37.57	27251275
355	Phosphorylation	HLVQHQRTHTGEKPY HHHHHCCCCCCCCCC	19.74	-
357	Phosphorylation	VQHQRTHTGEKPYEC HHHCCCCCCCCCCCC	46.56	-
372	Phosphorylation	NACGKSFSRSSHLIT CCCCCCCCCCCCCCE	38.04	17081983
385	Phosphorylation	ITHQKIHTGEKPYEC CEECEEECCCCCCCC	50.97	28655764
411	Phosphorylation	DLIKHQRTHTGEKPY HHHHHCCCCCCCCCE	19.74	-
413	Phosphorylation	IKHQRTHTGEKPYEC HHHCCCCCCCCCEEE	46.56	21712546
418	Phosphorylation	THTGEKPYECVQCGK CCCCCCCEEEEECCC	32.78	-
425	Sumoylation	YECVQCGKGFTQSSN EEEEECCCCCCCCCC	59.48	-
425	Sumoylation	YECVQCGKGFTQSSN EEEEECCCCCCCCCC	59.48	-
441	Phosphorylation	ITHQRVHTGEKPYEC EECCEEECCCCCCCC	44.15	-
449	Phosphorylation	GEKPYECTECEKSFS CCCCCCCCCCCCCCC	31.56	28985074
456	Phosphorylation	TECEKSFSRSSALIK CCCCCCCCCCCHHHH	38.04	17081983
465	Methylation	SSALIKHKRVHTD-- CCHHHHCCCCCCC--	51.63	116253735

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN436_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN436_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN436_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SUV91_HUMAN	SUV39H1	physical	23455924
KDM1A_HUMAN	KDM1A	physical	23455924
ANM5_HUMAN	PRMT5	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.