RGS13_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS13_HUMAN
• UniProt AC: O14921
• Protein Name: Regulator of G-protein signaling 13
• Gene Name: RGS13
• Organism: Homo sapiens (Human).
• Sequence Length: 159
• Protein Description: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity)..
• Protein Sequence: MSRRNCWICKMCRDESKRPPSNLTLEEVLQWAQSFENLMATKYGPVVYAAYLKMEHSDENIQFWMACETYKKIASRWSRISRAKKLYKIYIQPQSPREINIDSSTRETIIRNIQEPTETCFEEAQKIVYMHMERDSYPRFLKSEMYQKLLKTMQSNNSF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	SFENLMATKYGPVVY HHHHHHHHCHHHHHE	15.72	22817900
48	Phosphorylation	TKYGPVVYAAYLKME HCHHHHHEEEEEECC	5.92	-
51	Phosphorylation	GPVVYAAYLKMEHSD HHHHEEEEEECCCCC	9.93	-
142	Ubiquitination	DSYPRFLKSEMYQKL CCCCHHHHHHHHHHH	41.48	-
146	Phosphorylation	RFLKSEMYQKLLKTM HHHHHHHHHHHHHHH	9.84	-
148	Ubiquitination	LKSEMYQKLLKTMQS HHHHHHHHHHHHHHH	38.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
41	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
41	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS13_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS13_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GNAI2_HUMAN	GNAI2	physical	12193720
GNA11_HUMAN	GNA11	physical	12193720
CC140_HUMAN	CCDC140	physical	28514442
LIN9_HUMAN	LIN9	physical	28514442
SLAF1_HUMAN	SLAMF1	physical	28514442
SRRT_HUMAN	SRRT	physical	28514442
CIAO1_HUMAN	CIAO1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.