dbPTM

SLAF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SLAF1_HUMAN
UniProt AC	Q13291
Protein Name	Signaling lymphocytic activation molecule
Gene Name	SLAMF1
Organism	Homo sapiens (Human).
Sequence Length	335
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Present on the surface of B-cells and T-cells. Located at the plasma membrane contacts between neighboring T-cells (PubMed:11806999). Isoform 3: Secreted . Isoform 4: Cell membrane . Overexp
Protein Description	Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAMF1 signaling seem to exist: one depending on SH2D1A (and perhaps SH2D1B) and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates. Initially it has been proposed that association with SH2D1A prevents binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. [PubMed: 11806999 However, signaling is also regulated by SH2D1A which can simultaneously interact with and recruit FYN which subsequently phosphorylates and activates SLAMF1]
Protein Sequence	MDPKGLLSLTFVLFLSLAFGASYGTGGRMMNCPKILRQLGSKVLLPLTYERINKSMNKSIHIVVTMAKSLENSVENKIVSLDPSEAGPPRYLGDRYKFYLENLTLGIRESRKEDEGWYLMTLEKNVSVQRFCLQLRLYEQVSTPEIKVLNKTQENGTCTLILGCTVEKGDHVAYSWSEKAGTHPLNPANSSHLLSLTLGPQHADNIYICTVSNPISNNSQTFSPWPGCRTDPSETKPWAVYAGLLGGVIMILIMVVILQLRRRGKTNHYQTTVEKKSLTIYAQVQKPGPLQKKLDSFPAQDPCTTIYVAATEPVPESVQETNSITVYASVTLPES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	N-linked_Glycosylation	PLTYERINKSMNKSI ECCHHHHHHHCCCCE	36.25	UniProtKB CARBOHYD
57	N-linked_Glycosylation	ERINKSMNKSIHIVV HHHHHHCCCCEEEEE	41.85	UniProtKB CARBOHYD
73	Phosphorylation	MAKSLENSVENKIVS CHHHHCHHHHCCEEE	22.79	-
102	N-linked_Glycosylation	RYKFYLENLTLGIRE HHHHHHHHEEEEEEE	35.41	UniProtKB CARBOHYD
118	Phosphorylation	RKEDEGWYLMTLEKN CCCCCCEEEEEEECC	9.46	28555341
121	Phosphorylation	DEGWYLMTLEKNVSV CCCEEEEEEECCCCH	29.21	28555341
125	N-linked_Glycosylation	YLMTLEKNVSVQRFC EEEEEECCCCHHHHH	23.17	UniProtKB CARBOHYD
147	Ubiquitination	QVSTPEIKVLNKTQE CCCCCCEEEEEECCC	38.72	25015289
150	N-linked_Glycosylation	TPEIKVLNKTQENGT CCCEEEEEECCCCCE	48.60	UniProtKB CARBOHYD
153	Ubiquitination	IKVLNKTQENGTCTL EEEEEECCCCCEEEE	43.71	25015289
155	N-linked_Glycosylation	VLNKTQENGTCTLIL EEEECCCCCEEEEEE	41.05	UniProtKB CARBOHYD
189	N-linked_Glycosylation	THPLNPANSSHLLSL CCCCCCCCCCCEEEE	45.35	UniProtKB CARBOHYD
217	N-linked_Glycosylation	TVSNPISNNSQTFSP EECCCCCCCCCCCCC	53.55	UniProtKB CARBOHYD
256	Ubiquitination	IMILIMVVILQLRRR HHHHHHHHHHHHHHC	1.68	25015289
262	Ubiquitination	VVILQLRRRGKTNHY HHHHHHHHCCCCCCC	61.36	25015289
266	Phosphorylation	QLRRRGKTNHYQTTV HHHHCCCCCCCEEEE	30.01	29978859
269	Phosphorylation	RRGKTNHYQTTVEKK HCCCCCCCEEEEEEC	15.04	29978859
271	Phosphorylation	GKTNHYQTTVEKKSL CCCCCCEEEEEECEE	26.16	30622161
272	Phosphorylation	KTNHYQTTVEKKSLT CCCCCEEEEEECEEE	15.90	30622161
277	Phosphorylation	QTTVEKKSLTIYAQV EEEEEECEEEEEEEE	41.64	30108239
279	Phosphorylation	TVEKKSLTIYAQVQK EEEECEEEEEEEECC	21.02	30108239
281	Phosphorylation	EKKSLTIYAQVQKPG EECEEEEEEEECCCC	5.92	11806999
286	Ubiquitination	TIYAQVQKPGPLQKK EEEEEECCCCCHHHH	53.75	25015289
292	Ubiquitination	QKPGPLQKKLDSFPA CCCCCHHHHHCCCCC	64.09	25015289
307	Phosphorylation	QDPCTTIYVAATEPV CCCCCEEEEEECCCC	5.07	11806999
327	Phosphorylation	ETNSITVYASVTLPE CCCCEEEEEEEECCC	5.63	11806999

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
281	Y	Phosphorylation	Kinase	FYN	P06241	Uniprot
307	Y	Phosphorylation	Kinase	FYN	P06241	Uniprot
307	Y	Phosphorylation	Kinase	LCK	P06239	PSP
327	Y	Phosphorylation	Kinase	FYN	P06241	Uniprot
327	Y	Phosphorylation	Kinase	LYN	P07948	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF9	Q86YJ5	PMID:19457934

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SLAF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SLAF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SH21A_HUMAN	SH2D1A	physical	11806999
PTN11_HUMAN	PTPN11	physical	11806999
FGR_HUMAN	FGR	physical	10229804
SHIP1_HUMAN	INPP5D	physical	10229804
PTPRC_HUMAN	PTPRC	physical	10229804
PTN11_HUMAN	PTPN11	physical	11689425
SH21B_HUMAN	SH2D1B	physical	22974441
SLAF1_HUMAN	SLAMF1	physical	21982860
S39AB_HUMAN	SLC39A11	physical	26186194
AT1A3_HUMAN	ATP1A3	physical	26186194
AT12A_HUMAN	ATP12A	physical	26186194
AT2B2_HUMAN	ATP2B2	physical	26186194
AT2B3_HUMAN	ATP2B3	physical	26186194
NF1_HUMAN	NF1	physical	26186194
HEAT1_HUMAN	HEATR1	physical	26186194
PYRG2_HUMAN	CTPS2	physical	26186194
INT4_HUMAN	INTS4	physical	26186194
NU188_HUMAN	NUP188	physical	26186194
QCR2_HUMAN	UQCRC2	physical	26186194
GLPK2_HUMAN	GK2	physical	26186194
GLPK_HUMAN	GK	physical	26186194
ELYS_HUMAN	AHCTF1	physical	26186194
INT2_HUMAN	INTS2	physical	26186194
BIG1_HUMAN	ARFGEF1	physical	26186194
BIG2_HUMAN	ARFGEF2	physical	26186194
LTN1_HUMAN	LTN1	physical	26186194
MD2L2_HUMAN	MAD2L2	physical	26186194
LEG1_HUMAN	LGALS1	physical	26186194
HEAT6_HUMAN	HEATR6	physical	26186194
ANTR1_HUMAN	ANTXR1	physical	26186194
HUS1_HUMAN	HUS1	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
URB2_HUMAN	URB2	physical	26186194
OCLN_HUMAN	OCLN	physical	26186194
TOM40_HUMAN	TOMM40	physical	26186194
UFSP2_HUMAN	UFSP2	physical	26186194
AN13A_HUMAN	ANKRD13A	physical	26186194
VPS52_HUMAN	VPS52	physical	26186194
INT12_HUMAN	INTS12	physical	26186194
RAB3B_HUMAN	RAB3B	physical	26186194
S27A6_HUMAN	SLC27A6	physical	26186194
ARF5_HUMAN	ARF5	physical	26186194
RAB18_HUMAN	RAB18	physical	26186194
CHPT1_HUMAN	CHPT1	physical	26186194
INT1_HUMAN	INTS1	physical	26186194
RAB5A_HUMAN	RAB5A	physical	26186194
ORNT1_HUMAN	SLC25A15	physical	26186194
TAM41_HUMAN	TAMM41	physical	26186194
ZN292_HUMAN	ZNF292	physical	26186194
INT7_HUMAN	INTS7	physical	26186194
COT2_HUMAN	NR2F2	physical	26186194
ERAP1_HUMAN	ERAP1	physical	26186194
MTCH1_HUMAN	MTCH1	physical	26186194
MYADM_HUMAN	MYADM	physical	26186194
SGPP1_HUMAN	SGPP1	physical	26186194
GATB_HUMAN	GATB	physical	26186194
PTCD2_HUMAN	PTCD2	physical	26186194
STML1_HUMAN	STOML1	physical	26186194
XRCC3_HUMAN	XRCC3	physical	26186194
EAA3_HUMAN	SLC1A1	physical	26186194
CNTP3_HUMAN	CNTNAP3	physical	28514442
GPR98_HUMAN	GPR98	physical	28514442
RTCA_HUMAN	RTCA	physical	28514442
KBRS1_HUMAN	NKIRAS1	physical	28514442
FUT11_HUMAN	FUT11	physical	28514442
GT253_HUMAN	CERCAM	physical	28514442
ATS2_HUMAN	ADAMTS2	physical	28514442
ITA7_HUMAN	ITGA7	physical	28514442
CBPE_HUMAN	CPE	physical	28514442
D2HDH_HUMAN	D2HGDH	physical	28514442
GLT18_HUMAN	GALNT18	physical	28514442
CHLE_HUMAN	BCHE	physical	28514442
LIFR_HUMAN	LIFR	physical	28514442
ANAG_HUMAN	NAGLU	physical	28514442
TXD15_HUMAN	TXNDC15	physical	28514442
LARG1_HUMAN	LARGE	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
PYC_HUMAN	PC	physical	28514442
EPHA3_HUMAN	EPHA3	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
MOXD1_HUMAN	MOXD1	physical	28514442
CBWD1_HUMAN	CBWD1	physical	28514442
FAT1_HUMAN	FAT1	physical	28514442
LAMB2_HUMAN	LAMB2	physical	28514442
T132A_HUMAN	TMEM132A	physical	28514442
CELR1_HUMAN	CELSR1	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
CSTN1_HUMAN	CLSTN1	physical	28514442
SIA10_HUMAN	ST3GAL6	physical	28514442
I17RA_HUMAN	IL17RA	physical	28514442
OS9_HUMAN	OS9	physical	28514442
DUSTY_HUMAN	DSTYK	physical	28514442
SE1L1_HUMAN	SEL1L	physical	28514442
ATG2B_HUMAN	ATG2B	physical	28514442
PCSK5_HUMAN	PCSK5	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
LAMA3_HUMAN	LAMA3	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
FAKD3_HUMAN	FASTKD3	physical	28514442
ACHA5_HUMAN	CHRNA5	physical	28514442
GFPT2_HUMAN	GFPT2	physical	28514442
NAGAB_HUMAN	NAGA	physical	28514442
BMP7_HUMAN	BMP7	physical	28514442
CAHD1_HUMAN	CACHD1	physical	28514442
ANR46_HUMAN	ANKRD46	physical	28514442
THUM3_HUMAN	THUMPD3	physical	28514442
IGF1R_HUMAN	IGF1R	physical	28514442
FRAS1_HUMAN	FRAS1	physical	28514442
ADAM9_HUMAN	ADAM9	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SLAF1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-281, AND MASSSPECTROMETRY.	18083107 [Abstract]