| UniProt ID | GLPK2_HUMAN | |
|---|---|---|
| UniProt AC | Q14410 | |
| Protein Name | Glycerol kinase 2 | |
| Gene Name | GK2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 553 | |
| Subcellular Localization |
Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm. In sperm the majority of the enzyme is bound to mitochondria.. |
|
| Protein Description | Key enzyme in the regulation of glycerol uptake and metabolism.. | |
| Protein Sequence | MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEILQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIYGLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLRHLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALSVLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSMVMLIGARYISGVP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | Acetylation | CIARTCEKLDELNID HHHHHHHHHHHCCEE | 64.48 | 25038526 | |
| 109 | Phosphorylation | KLTGEPLYNAVVWLD CCCCCCCCEEEEEEE | 16.28 | - | |
| 139 | Phosphorylation | GNSNFVKSKTGLPLS CCCCCCCCCCCCCHH | 30.10 | 22210691 | |
| 140 | Ubiquitination | NSNFVKSKTGLPLST CCCCCCCCCCCCHHH | 40.68 | - | |
| 141 | Phosphorylation | SNFVKSKTGLPLSTY CCCCCCCCCCCHHHH | 51.55 | 22210691 | |
| 146 | Phosphorylation | SKTGLPLSTYFSAVK CCCCCCHHHHHHHHH | 21.08 | 29978859 | |
| 147 | Phosphorylation | KTGLPLSTYFSAVKL CCCCCHHHHHHHHHH | 35.95 | 29978859 | |
| 148 | Phosphorylation | TGLPLSTYFSAVKLR CCCCHHHHHHHHHHH | 7.67 | 22210691 | |
| 150 | Phosphorylation | LPLSTYFSAVKLRWM CCHHHHHHHHHHHHH | 23.03 | 22210691 | |
| 315 | Phosphorylation | LGREKPAYYALEGSV HCCCCCCEEEEECHH | 9.59 | 18491316 | |
| 316 | Phosphorylation | GREKPAYYALEGSVA CCCCCCEEEEECHHH | 13.55 | 18491316 | |
| 480 | Phosphorylation | SLEPQALSVLRMERF ECCHHHHHHHHHHHC | 23.32 | 24719451 | |
| 494 | Phosphorylation | FEPQIQATESEIRYA CCHHHHCCHHHHHHH | 24.54 | 28509920 | |
| 500 | Phosphorylation | ATESEIRYATWKKAV CCHHHHHHHHHHHHH | 17.66 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GLPK2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GLPK2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GLPK2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HSP7C_HUMAN | HSPA8 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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