KBRS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KBRS1_HUMAN
• UniProt AC: Q9NYS0
• Protein Name: NF-kappa-B inhibitor-interacting Ras-like protein 1
• Gene Name: NKIRAS1
• Organism: Homo sapiens (Human).
• Sequence Length: 192
• Subcellular Localization: Cytoplasm .
• Protein Description: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB..
• Protein Sequence: MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLPGRKNKGNSNSEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Ubiquitination	VETDRGVKEQLHLYD EECCCCHHHHEEEEC	42.43	29967540
108	Ubiquitination	KKEIDKFKDKKEVAI HHHHHHCCCCCCEEE	74.50	-
135	Ubiquitination	RQVDAEVAQQWAKSE HHHHHHHHHHHHHCC	6.32	30230243
140	Ubiquitination	EVAQQWAKSEKVRLW HHHHHHHHCCCEEEE	57.07	21906983
141	Phosphorylation	VAQQWAKSEKVRLWE HHHHHHHCCCEEEEE	34.60	23911959
142	Ubiquitination	AQQWAKSEKVRLWEV HHHHHHCCCEEEEEE	55.66	32142685
143	Acetylation	QQWAKSEKVRLWEVT HHHHHCCCEEEEEEE	39.48	19825055
143	Ubiquitination	QQWAKSEKVRLWEVT HHHHHCCCEEEEEEE	39.48	22817900
150	Phosphorylation	KVRLWEVTVTDRKTL CEEEEEEEECCCCHH	13.23	23911959
152	Phosphorylation	RLWEVTVTDRKTLIE EEEEEEECCCCHHHC	22.26	23911959
155	Ubiquitination	EVTVTDRKTLIEPFT EEEECCCCHHHCHHH	50.96	-
166	Phosphorylation	EPFTLLASKLSQPQS CHHHHHHHHHCCCCC	33.81	-
167	Ubiquitination	PFTLLASKLSQPQSK HHHHHHHHHCCCCCC	46.69	21963094
174	Ubiquitination	KLSQPQSKSSFPLPG HHCCCCCCCCCCCCC	44.89	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KBRS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KBRS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KBRS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IKBB_HUMAN	NFKBIB	physical	12672800
A4_HUMAN	APP	physical	21832049
XRCC2_HUMAN	XRCC2	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.