dbPTM

SH21A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SH21A_HUMAN
UniProt AC	O60880
Protein Name	SH2 domain-containing protein 1A
Gene Name	SH2D1A
Organism	Homo sapiens (Human).
Sequence Length	128
Subcellular Localization	Cytoplasm .
Protein Description	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. [PubMed: 11806999 However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1]
Protein Sequence	MDAVAVYHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGTTGIREDPDVCLKAP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MDAVAVYHGKISRE -CCEEEEECCEECHH	8.63	24719451
10	Ubiquitination	AVAVYHGKISRETGE EEEEECCEECHHHCC	24.97	24816145
12	Phosphorylation	AVYHGKISRETGEKL EEECCEECHHHCCEE	27.78	24719451
15	Phosphorylation	HGKISRETGEKLLLA CCEECHHHCCEEEEE	49.91	23879269
18	Ubiquitination	ISRETGEKLLLATGL ECHHHCCEEEEEECC	45.86	-
23	Phosphorylation	GEKLLLATGLDGSYL CCEEEEEECCCCCEE	37.94	24719451
28	Phosphorylation	LATGLDGSYLLRDSE EEECCCCCEECCCCC	16.57	24719451
29	Phosphorylation	ATGLDGSYLLRDSES EECCCCCEECCCCCC	18.45	24719451
74	Ubiquitination	ETAPGVHKRYFRKIK CCCCCHHHHHHHHHH	46.52	-
81	Ubiquitination	KRYFRKIKNLISAFQ HHHHHHHHHHHHHHC	49.05	29967540
89	Acetylation	NLISAFQKPDQGIVI HHHHHHCCCCCCEEE	44.07	19608861
89	Ubiquitination	NLISAFQKPDQGIVI HHHHHHCCCCCCEEE	44.07	19608861
104	Ubiquitination	PLQYPVEKKSSARST EECCEECCCCCCCCC	59.18	-
105	Ubiquitination	LQYPVEKKSSARSTQ ECCEECCCCCCCCCC	35.82	-
106	Phosphorylation	QYPVEKKSSARSTQG CCEECCCCCCCCCCC	40.05	22817900
107	Phosphorylation	YPVEKKSSARSTQGT CEECCCCCCCCCCCC	36.26	22817900
110	Phosphorylation	EKKSSARSTQGTTGI CCCCCCCCCCCCCCC	25.46	27251275
111	Phosphorylation	KKSSARSTQGTTGIR CCCCCCCCCCCCCCC	26.01	-
114	Phosphorylation	SARSTQGTTGIREDP CCCCCCCCCCCCCCC	16.42	-
115	Phosphorylation	ARSTQGTTGIREDPD CCCCCCCCCCCCCCC	37.12	-
126	Ubiquitination	EDPDVCLKAP----- CCCCCCEECC-----	54.18	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SH21A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SH21A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SH21A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SLAF1_HUMAN	SLAMF1	physical	11806999
SLAF5_HUMAN	CD84	physical	12928397
FYN_HUMAN	FYN	physical	12458214
SLAF5_HUMAN	CD84	physical	11389028
LY9_HUMAN	LY9	physical	11389028
DOK1_HUMAN	DOK1	physical	10852966
SLAF1_HUMAN	SLAMF1	physical	11477068
CD244_HUMAN	CD244	physical	11477068
LY9_HUMAN	LY9	physical	11477068
SLAF5_HUMAN	CD84	physical	11477068
EGFR_HUMAN	EGFR	physical	16273093
ERBB3_HUMAN	ERBB3	physical	16273093
ACK1_HUMAN	TNK2	physical	25416956
LHX4_HUMAN	LHX4	physical	25416956
FAK1_HUMAN	PTK2	physical	25814554
ZNHI1_HUMAN	ZNHIT1	physical	25814554
ATF3_HUMAN	ATF3	physical	25814554
CC74A_HUMAN	CCDC74A	physical	25814554
LTMD1_HUMAN	LETMD1	physical	25814554
NGEF_HUMAN	NGEF	physical	25814554
OLIG1_HUMAN	OLIG1	physical	25814554
TERA_HUMAN	VCP	physical	19570996

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
308240	Lymphoproliferative syndrome, X-linked, 1 (XLP1)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SH21A_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-89, AND MASS SPECTROMETRY.	19608861 [Abstract]