EFMT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFMT1_HUMAN
• UniProt AC: Q8WVE0
• Protein Name: EEF1A lysine methyltransferase 1 {ECO:0000255|HAMAP-Rule:MF_03187, ECO:0000312|HGNC:HGNC:27351}
• Gene Name: EEF1AKMT1 {ECO:0000255|HAMAP-Rule:MF_03187, ECO:0000312|HGNC:HGNC:27351}
• Organism: Homo sapiens (Human).
• Sequence Length: 214
• Subcellular Localization: Cytoplasm .
• Protein Description: Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'..
• Protein Sequence: MSDLEDDETPQLSAHALAALQEFYAEQKQQIEPGEDDKYNIGIIEENWQLSQFWYSQETALQLAQEAIAAVGEGGRIACVSAPSVYQKLRELCRENFSIYIFEYDKRFAMYGEEFIFYDYNNPLDLPERIAAHSFDIVIADPPYLSEECLRKTSETVKYLTRGKILLCTGAIMEEQAAELLGVKMCTFVPRHTRNLANEFRCYVNYDSGLDCGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDLEDDET ------CCCCCCCCC		19413330
2	Phosphorylation	------MSDLEDDET ------CCCCCCCCC		26055452
9	Phosphorylation	SDLEDDETPQLSAHA CCCCCCCCHHHHHHH		26074081
13	Phosphorylation	DDETPQLSAHALAAL CCCCHHHHHHHHHHH		26074081
24	Phosphorylation	LAALQEFYAEQKQQI HHHHHHHHHHHHHHC		26074081
88	Ubiquitination	SAPSVYQKLRELCRE CCHHHHHHHHHHHHH		-
100	Phosphorylation	CRENFSIYIFEYDKR HHHCCEEEEEEECHH		-
158	Ubiquitination	RKTSETVKYLTRGKI HCCHHHHHHHHHCCE		-
159	Phosphorylation	KTSETVKYLTRGKIL CCHHHHHHHHHCCEE		24719451
161	Phosphorylation	SETVKYLTRGKILLC HHHHHHHHHCCEEEE		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFMT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFMT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFMT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1A2_HUMAN	EEF1A2	physical	28514442
TTL12_HUMAN	TTLL12	physical	28514442
EF1A1_HUMAN	EEF1A1	physical	28514442
NFS1_HUMAN	NFS1	physical	28514442
EGLN1_HUMAN	EGLN1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.