| UniProt ID | SCRB2_HUMAN | |
|---|---|---|
| UniProt AC | Q14108 | |
| Protein Name | Lysosome membrane protein 2 | |
| Gene Name | SCARB2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 478 | |
| Subcellular Localization |
Lysosome membrane Multi-pass membrane protein . |
|
| Protein Description | Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting.; (Microbial infection) Acts as a receptor for enterovirus 71.. | |
| Protein Sequence | MGRCCFYTAGTLSLLLLVTSVTLLVARVFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGETPRVEEVGPYTYRELRNKANIQFGDNGTTISAVSNKAYVFERDQSVGDPKIDLIRTLNIPVLTVIEWSQVHFLREIIEAMLKAYQQKLFVTHTVDELLWGYKDEILSLIHVFRPDISPYFGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWITDKCNMINGTDGDSFHPLITKDEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVPAEILANTSDNAGFCIPEGNCLGSGVLNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIYVKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTTLIITNIPYIIMALGVFFGLVFTWLACKGQGSMDEGTADERAPLIRT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MGRCCFYTAGTLSL -CCCCCCCCHHHHHH | 5.03 | 24043423 | |
| 8 | Phosphorylation | MGRCCFYTAGTLSLL CCCCCCCCHHHHHHH | 9.81 | 24043423 | |
| 11 | Phosphorylation | CCFYTAGTLSLLLLV CCCCCHHHHHHHHHH | 15.65 | 24043423 | |
| 13 | Phosphorylation | FYTAGTLSLLLLVTS CCCHHHHHHHHHHHH | 19.46 | 24043423 | |
| 19 | Phosphorylation | LSLLLLVTSVTLLVA HHHHHHHHHHHHHHH | 19.90 | 24043423 | |
| 20 | Phosphorylation | SLLLLVTSVTLLVAR HHHHHHHHHHHHHHH | 12.96 | 24043423 | |
| 22 | Phosphorylation | LLLVTSVTLLVARVF HHHHHHHHHHHHHHH | 17.72 | 24043423 | |
| 39 | 2-Hydroxyisobutyrylation | AVDQSIEKKIVLRNG HHHHHHHHHEEEECC | 46.24 | - | |
| 45 | N-linked_Glycosylation | EKKIVLRNGTEAFDS HHHEEEECCCCCCCC | 58.54 | 24162852 | |
| 68 | N-linked_Glycosylation | YTQFYFFNVTNPEEI EEEEEEEECCCHHHH | 29.79 | 24162852 | |
| 89 | Phosphorylation | RVEEVGPYTYRELRN CCCEECCCCHHHHHH | 15.52 | - | |
| 90 | Phosphorylation | VEEVGPYTYRELRNK CCEECCCCHHHHHHH | 21.16 | - | |
| 105 | N-linked_Glycosylation | ANIQFGDNGTTISAV CCEEECCCCCEEEEE | 50.52 | 17660510 | |
| 129 | 2-Hydroxyisobutyrylation | DQSVGDPKIDLIRTL CCCCCCCCCHHHHCC | 54.30 | - | |
| 206 | N-linked_Glycosylation | FGLFYEKNGTNDGDY CEEEEEECCCCCCCE | 51.05 | 24162852 | |
| 224 | N-linked_Glycosylation | TGEDSYLNFTKIVEW ECCCCCEEEEEEEEE | 34.02 | 24162852 | |
| 249 | N-linked_Glycosylation | TDKCNMINGTDGDSF ECCCCCCCCCCCCCC | 36.22 | 24162852 | |
| 282 | Phosphorylation | RSVYITFSDYESVQG CEEEEEECCCHHCCC | 30.54 | 18220336 | |
| 284 | Phosphorylation | VYITFSDYESVQGLP EEEEECCCHHCCCCC | 14.65 | 18220336 | |
| 304 | N-linked_Glycosylation | VPAEILANTSDNAGF CCHHHHCCCCCCCCE | 36.35 | 24162852 | |
| 325 | N-linked_Glycosylation | CLGSGVLNVSICKNG EECCCCEEEEEECCC | 24.08 | 24162852 | |
| 373 | Phosphorylation | FVDINPLTGIILKAA ECCCCCCCHHHHHHH | 27.82 | - | |
| 388 | Phosphorylation | KRFQINIYVKKLDDF HHCCEEEEEEEHHHH | 11.17 | 18452278 | |
| 391 | 2-Hydroxyisobutyrylation | QINIYVKKLDDFVET CEEEEEEEHHHHHHC | 47.29 | - | |
| 412 | N-linked_Glycosylation | VFPVMYLNESVHIDK EEEEEECCCCEECCH | 23.24 | 12754519 | |
| 430 | N-linked_Glycosylation | SRLKSMINTTLIITN HHHHHHHHCCHHHCC | 20.54 | UniProtKB CARBOHYD | |
| 458 | S-palmitoylation | LVFTWLACKGQGSMD HHHHHHHHCCCCCCC | 4.82 | 29575903 | |
| 463 | Phosphorylation | LACKGQGSMDEGTAD HHHCCCCCCCCCCCC | 18.38 | - | |
| 468 | Phosphorylation | QGSMDEGTADERAPL CCCCCCCCCCCCCCC | 28.96 | - | |
| 478 | Phosphorylation | ERAPLIRT------- CCCCCCCC------- | 35.65 | 25159151 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SCRB2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SCRB2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SCRB2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TSP1_HUMAN | THBS1 | physical | 9478926 | |
| E2AK2_HUMAN | EIF2AK2 | physical | 26496610 | |
| PRP8_HUMAN | PRPF8 | physical | 26496610 | |
| PNKD_HUMAN | PNKD | physical | 26496610 | |
| MYOF_HUMAN | MYOF | physical | 26496610 | |
| VAMP3_HUMAN | VAMP3 | physical | 28514442 | |
| JIP4_HUMAN | SPAG9 | physical | 28514442 | |
| GLMN_HUMAN | GLMN | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00810 | Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease ( | |||||
| OMIM Disease | ||||||
| 254900 | Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45; ASN-68; ASN-105;ASN-206; ASN-249; ASN-304 AND ASN-325, AND MASS SPECTROMETRY. | |
| "Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry."; Zhang H., Li X.-J., Martin D.B., Aebersold R.; Nat. Biotechnol. 21:660-666(2003). Cited for: GLYCOSYLATION AT ASN-249 AND ASN-412. | |
