dbPTM

NCOA7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCOA7_HUMAN
UniProt AC	Q8NI08
Protein Name	Nuclear receptor coactivator 7
Gene Name	NCOA7
Organism	Homo sapiens (Human).
Sequence Length	942
Subcellular Localization	Nucleus .
Protein Description	Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA..
Protein Sequence	MDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRYYSIDDNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGATVSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDLPQDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGHTPTKPSGSSVSEKLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLEELSSQTGGGMHKKDTLKECLSLDPEERKKAESQINNSAVEMQVQSALAFLGTENDVELKGALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVSENLQKTELSDGKSIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEANVIKEALDSSLESTLDNSCQGAQMDNKSEVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAKEQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIVQDLEVWAFD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDTKEEKK -------CCCHHHHH	15.48	22814378
13	Phosphorylation	EKKERKQSYFARLKK HHHHHHHHHHHHHHH	25.83	27732954
14	Phosphorylation	KKERKQSYFARLKKK HHHHHHHHHHHHHHH	9.96	27732954
38	Phosphorylation	ASAVATRTHTGKEDN HHHHHHCCCCCCCCC	21.31	21712546
40	Phosphorylation	AVATRTHTGKEDNNT HHHHCCCCCCCCCCE	49.70	21712546
82	Phosphorylation	QLKEIRRTELKRYYS HHHHHHHHHHHHHEE	35.50	29083192
87	Phosphorylation	RRTELKRYYSIDDNQ HHHHHHHHEECCCCC	10.44	28796482
88	Phosphorylation	RTELKRYYSIDDNQN HHHHHHHEECCCCCC	11.81	22167270
89	Phosphorylation	TELKRYYSIDDNQNK HHHHHHEECCCCCCC	15.59	23401153
109	Ubiquitination	EKKMVVQKPHGTMEY CCCEEEECCCCCEEE	27.63	-
134	Phosphorylation	IALKFNITPNKLVEL HEHHCCCCHHHEEHH	23.16	22167270
162	Phosphorylation	LFVPDANSPSSTLRL EEECCCCCCCCEEEE	28.07	29255136
164	Phosphorylation	VPDANSPSSTLRLSS ECCCCCCCCEEEECC	35.46	29255136
165	Phosphorylation	PDANSPSSTLRLSSS CCCCCCCCEEEECCC	34.54	29255136
166	Phosphorylation	DANSPSSTLRLSSSS CCCCCCCEEEECCCC	21.89	29255136
170	Phosphorylation	PSSTLRLSSSSPGAT CCCEEEECCCCCCCE	23.03	23401153
171	Phosphorylation	SSTLRLSSSSPGATV CCEEEECCCCCCCEE	39.15	25159151
172	Phosphorylation	STLRLSSSSPGATVS CEEEECCCCCCCEEC	36.86	25159151
173	Phosphorylation	TLRLSSSSPGATVSP EEEECCCCCCCEECC	29.33	23401153
177	Phosphorylation	SSSSPGATVSPSSSD CCCCCCCEECCCCCC	27.68	23927012
179	Phosphorylation	SSPGATVSPSSSDAE CCCCCEECCCCCCCC	18.08	23401153
181	Phosphorylation	PGATVSPSSSDAEYD CCCEECCCCCCCCHH	34.66	23927012
182	Phosphorylation	GATVSPSSSDAEYDK CCEECCCCCCCCHHC	35.30	23927012
183	Phosphorylation	ATVSPSSSDAEYDKL CEECCCCCCCCHHCC	45.22	23927012
187	Phosphorylation	PSSSDAEYDKLPDAD CCCCCCCHHCCCCHH	21.79	23927012
191 (in isoform 7)	Phosphorylation	-	40.25	28355574
208	Phosphorylation	KPIERVLSSTSEEDE HHHHHHHCCCCCCCC	28.81	23927012
209	Phosphorylation	PIERVLSSTSEEDEP HHHHHHCCCCCCCCC	31.62	29255136
210	Phosphorylation	IERVLSSTSEEDEPG HHHHHCCCCCCCCCC	36.46	29255136
211	Phosphorylation	ERVLSSTSEEDEPGV HHHHCCCCCCCCCCH	40.72	19664994
220	Ubiquitination	EDEPGVVKFLKMNCR CCCCCHHEEEEECCE	42.44	-
235 (in isoform 4)	Phosphorylation	-	4.05	25278378
236 (in isoform 4)	Phosphorylation	-	8.23	25278378
243 (in isoform 4)	Phosphorylation	-	14.90	25278378
246 (in isoform 4)	Phosphorylation	-	28.45	25278378
290	Ubiquitination	DISHMKIKDALPSDL CCCCCCHHHCCCCCC	31.28	-
295 (in isoform 2)	Phosphorylation	-	53.26	28355574
305	Phosphorylation	PQDLCPLYRPGEWED CCCCCCCCCCCCHHH	10.41	27642862
317	Ubiquitination	WEDLASEKDINPFSK HHHHCCCCCCCCHHH	62.50	-
342	Phosphorylation	QNGEKIMTSDSRPIV HHCCCCCCCCCCCEE	32.62	28555341
343	Phosphorylation	NGEKIMTSDSRPIVP HCCCCCCCCCCCEEE	19.06	28555341
354	Phosphorylation	PIVPLEKSTGHTPTK CEEECCCCCCCCCCC	30.19	30266825
355	Phosphorylation	IVPLEKSTGHTPTKP EEECCCCCCCCCCCC	44.01	30266825
358	Phosphorylation	LEKSTGHTPTKPSGS CCCCCCCCCCCCCCC	33.72	23401153
360	Phosphorylation	KSTGHTPTKPSGSSV CCCCCCCCCCCCCCH	57.66	30266825
363	Phosphorylation	GHTPTKPSGSSVSEK CCCCCCCCCCCHHHH	53.51	30266825
365	Phosphorylation	TPTKPSGSSVSEKLK CCCCCCCCCHHHHHH	31.72	25159151
366	Phosphorylation	PTKPSGSSVSEKLKK CCCCCCCCHHHHHHH	32.94	26657352
368	Phosphorylation	KPSGSSVSEKLKKLD CCCCCCHHHHHHHHC	30.84	29396449
376	Phosphorylation	EKLKKLDSSRETSHG HHHHHHCCCCCCCCC	41.55	25159151
380	Phosphorylation	KLDSSRETSHGSPTV HHCCCCCCCCCCCCE	25.55	23403867
381	Phosphorylation	LDSSRETSHGSPTVT HCCCCCCCCCCCCEE	22.54	23403867
384	Phosphorylation	SRETSHGSPTVTKLS CCCCCCCCCCEEECC	16.39	25159151
386	Phosphorylation	ETSHGSPTVTKLSKE CCCCCCCCEEECCCC	42.37	23403867
388	Phosphorylation	SHGSPTVTKLSKEPS CCCCCCEEECCCCCC	28.84	23403867
391	Phosphorylation	SPTVTKLSKEPSDTS CCCEEECCCCCCCCC	36.21	27251275
395	Phosphorylation	TKLSKEPSDTSSAFE EECCCCCCCCCHHHH	55.39	22210691
397	Phosphorylation	LSKEPSDTSSAFEST CCCCCCCCCHHHHHH	28.99	21815630
398	Phosphorylation	SKEPSDTSSAFESTA CCCCCCCCHHHHHHH	25.35	27251275
399	Phosphorylation	KEPSDTSSAFESTAK CCCCCCCHHHHHHHH	38.78	27251275
403	Phosphorylation	DTSSAFESTAKENFL CCCHHHHHHHHHHCC	27.49	27251275
404	Phosphorylation	TSSAFESTAKENFLG CCHHHHHHHHHHCCC	34.25	27251275
423	Phosphorylation	FVDLEELSSQTGGGM CCCHHHHHHCCCCCC	24.55	27732954
424	Phosphorylation	VDLEELSSQTGGGMH CCHHHHHHCCCCCCC	44.37	22210691
426	Phosphorylation	LEELSSQTGGGMHKK HHHHHHCCCCCCCCC	39.48	22210691
435	Phosphorylation	GGMHKKDTLKECLSL CCCCCCCHHHHHHCC	48.92	26699800
441	Phosphorylation	DTLKECLSLDPEERK CHHHHHHCCCHHHHH	42.24	23401153
452	Phosphorylation	EERKKAESQINNSAV HHHHHHHHHHHHHHH	41.02	22468782
500	Phosphorylation	MPEVDKQSGSPESRV CCHHHCCCCCCHHHH	47.15	23401153
502	Phosphorylation	EVDKQSGSPESRVEN HHHCCCCCCHHHHHH	30.64	30266825
505	Phosphorylation	KQSGSPESRVENTLN CCCCCCHHHHHHHEE	45.04	30266825
510	Phosphorylation	PESRVENTLNIHEDL CHHHHHHHEECCCCH	14.00	28102081
519	Acetylation	NIHEDLDKVKLIEYY ECCCCHHHHHHHHHH	48.87	23954790
519	Ubiquitination	NIHEDLDKVKLIEYY ECCCCHHHHHHHHHH	48.87	-
525	Phosphorylation	DKVKLIEYYLTKNKE HHHHHHHHHHHCCCC	9.22	28796482
526	Phosphorylation	KVKLIEYYLTKNKEG HHHHHHHHHHCCCCC	8.63	28796482
531	Ubiquitination	EYYLTKNKEGPQVSE HHHHHCCCCCCCCCH	66.65	-
542	Ubiquitination	QVSENLQKTELSDGK CCCHHCCCCCCCCCC	47.32	-
550	Phosphorylation	TELSDGKSIEPGGID CCCCCCCCCCCCCEE	37.40	22468782
559	Phosphorylation	EPGGIDITLSSSLSQ CCCCEEEEECCCHHH	19.48	27732954
561	Phosphorylation	GGIDITLSSSLSQAG CCEEEEECCCHHHCC	14.83	27732954
562	Phosphorylation	GIDITLSSSLSQAGD CEEEEECCCHHHCCC	38.11	27732954
563	Phosphorylation	IDITLSSSLSQAGDP EEEEECCCHHHCCCC	28.76	27732954
565	Phosphorylation	ITLSSSLSQAGDPIT EEECCCHHHCCCCCC	21.67	30576142
572	Phosphorylation	SQAGDPITEGNKEPD HHCCCCCCCCCCCCC	43.14	27732954
595	Phosphorylation	PLPVKLNSSTEANVI CCCCCCCCCCCHHHH	49.42	29255136
596	Phosphorylation	LPVKLNSSTEANVIK CCCCCCCCCCHHHHH	29.24	29255136
597	Phosphorylation	PVKLNSSTEANVIKE CCCCCCCCCHHHHHH	38.65	29255136
608	Phosphorylation	VIKEALDSSLESTLD HHHHHHHHHHHHHHC	37.36	23403867
609	Phosphorylation	IKEALDSSLESTLDN HHHHHHHHHHHHHCC	35.50	23403867
612	Phosphorylation	ALDSSLESTLDNSCQ HHHHHHHHHHCCCCC	39.29	23403867
613	Phosphorylation	LDSSLESTLDNSCQG HHHHHHHHHCCCCCC	28.84	21815630
617	Phosphorylation	LESTLDNSCQGAQMD HHHHHCCCCCCCCCC	13.90	27251275
647	Phosphorylation	PIEDILPSKEEKSKT CHHHCCCCHHHHCCC	49.61	24719451
670	Phosphorylation	VGKPMRKSFATHTAA CCCCCHHHHHHHHHH	15.11	20068231
673	Phosphorylation	PMRKSFATHTAAMVQ CCHHHHHHHHHHHHH	20.11	20068231
682	Phosphorylation	TAAMVQQYGKRRKQP HHHHHHHHHHHCCCC	13.92	27642862
684	Acetylation	AMVQQYGKRRKQPEY HHHHHHHHHCCCCCC	44.06	25953088
691	Phosphorylation	KRRKQPEYWFAVPRE HHCCCCCCEEEEEHH	16.71	-
756	Ubiquitination	IITVEEAKRRKSTCS EEEHHHHHHHCCCCC	56.89	-
760	Phosphorylation	EEAKRRKSTCSYYED HHHHHHCCCCCCCCC	32.60	24247654
761	Phosphorylation	EAKRRKSTCSYYEDE HHHHHCCCCCCCCCC	14.43	26657352
763	Phosphorylation	KRRKSTCSYYEDEDE HHHCCCCCCCCCCCC	30.73	27251275
764	Phosphorylation	RRKSTCSYYEDEDEE HHCCCCCCCCCCCCC	17.02	27251275
765	Phosphorylation	RKSTCSYYEDEDEEV HCCCCCCCCCCCCCC	10.70	27251275
810	Phosphorylation	PWRLAYSTLEHGTSL CCHHHHHHHCCCCCH	24.40	20068231
816	Phosphorylation	STLEHGTSLKTLYRK HHHCCCCCHHHHHHH	32.25	20068231
818	Ubiquitination	LEHGTSLKTLYRKSA HCCCCCHHHHHHHCC	35.93	-
823	Ubiquitination	SLKTLYRKSASLDSP CHHHHHHHCCCCCCC	36.50	-
878	Phosphorylation	HFKVFKWSGENSYFI CEEEEEECCCCCEEE	36.50	20068231
882	Phosphorylation	FKWSGENSYFINGDI EEECCCCCEEEECCE	19.67	20068231
883	Phosphorylation	KWSGENSYFINGDIS EECCCCCEEEECCEE	21.76	20068231
918	Phosphorylation	HGRSNSCSTFNNDIL CCCCCCCHHCCCCHH	35.54	-
919	Phosphorylation	GRSNSCSTFNNDILS CCCCCCHHCCCCHHH	34.41	-
926	Phosphorylation	TFNNDILSKKEDFIV HCCCCHHHCCCCEEE	41.85	-
927	Ubiquitination	FNNDILSKKEDFIVQ CCCCHHHCCCCEEEC	57.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NCOA7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCOA7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCOA7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_HUMAN	ESR1	physical	11971969
GABPA_HUMAN	GABPA	physical	22863883
RB3GP_HUMAN	RAB3GAP1	physical	22863883

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCOA7_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89; SER-179; SER-208 ANDSER-211, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182; SER-183; SER-208AND SER-211, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-134; SER-208; SER-209;THR-210; SER-211 AND SER-441, AND MASS SPECTROMETRY.	18669648 [Abstract]