TNR17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR17_HUMAN
• UniProt AC: Q02223
• Protein Name: Tumor necrosis factor receptor superfamily member 17
• Gene Name: TNFRSF17
• Organism: Homo sapiens (Human).
• Sequence Length: 184
• Subcellular Localization: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Perinuclear Golgi-like structures.
• Protein Description: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK..
• Protein Sequence: MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Acetylation	KINSEPLKDEFKNTG HHCCCCCCHHHCCCC	66.96	10654605
86	Ubiquitination	KINSEPLKDEFKNTG HHCCCCCCHHHCCCC	66.96	-
92	Phosphorylation	LKDEFKNTGSGLLGM CCHHHCCCCCHHHEE	33.06	30108239
94	Phosphorylation	DEFKNTGSGLLGMAN HHHCCCCCHHHEEEE	24.99	24719451
106	Acetylation	MANIDLEKSRTGDEI EEECCCCCCCCCCEE	53.16	10654609
106	Ubiquitination	MANIDLEKSRTGDEI EEECCCCCCCCCCEE	53.16	22817900
121	Phosphorylation	ILPRGLEYTVEECTC EECCCCEEEEEEEEH	22.56	-
133	Ubiquitination	CTCEDCIKSKPKVDS EEHHHHHHCCCCCCC	59.77	-
135	Ubiquitination	CEDCIKSKPKVDSDH HHHHHHCCCCCCCCC	43.80	-
137	Ubiquitination	DCIKSKPKVDSDHCF HHHHCCCCCCCCCCC	63.51	-
160	Ubiquitination	ATILVTTKTNDYCKS CEEEEEECCCHHHHH	35.65	-
166	Ubiquitination	TKTNDYCKSLPAALS ECCCHHHHHHHHHHC	49.12	-
173	Phosphorylation	KSLPAALSATEIEKS HHHHHHHCCHHHHHH	28.55	26657352
175	Phosphorylation	LPAALSATEIEKSIS HHHHHCCHHHHHHHH	33.83	30108239
179	Ubiquitination	LSATEIEKSISAR-- HCCHHHHHHHHCC--	59.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNR17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF5_HUMAN	TRAF5	physical	20676093
TRAF6_HUMAN	TRAF6	physical	20676093
F105A_HUMAN	FAM105A	physical	28514442
F1711_HUMAN	FAM171A1	physical	28514442
OPA3_HUMAN	OPA3	physical	28514442
CD70_HUMAN	CD70	physical	28514442
PRKN_HUMAN	PARK2	physical	28514442
TARB1_HUMAN	TARBP1	physical	28514442
FACE1_HUMAN	ZMPSTE24	physical	28514442
TSN6_HUMAN	TSPAN6	physical	28514442
INT7_HUMAN	INTS7	physical	28514442
PLCA_HUMAN	AGPAT1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.