CD70_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD70_HUMAN
• UniProt AC: P32970
• Protein Name: CD70 antigen
• Gene Name: CD70
• Organism: Homo sapiens (Human).
• Sequence Length: 193
• Subcellular Localization: Membrane; Single-pass type II membrane protein.
• Protein Description: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells..
• Protein Sequence: MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAELQLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTASRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRNTDETFFGVQWVRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	S-palmitoylation	MPEEGSGCSVRRRPY CCCCCCCCCCCCCCC	3.49	29575903
17	S-palmitoylation	VRRRPYGCVLRAALV CCCCCCCHHHHHHHH	1.83	29575903
63	N-linked_Glycosylation	DVAELQLNHTGPQQD CEEEEECCCCCCCCC	20.08	UniProtKB CARBOHYD
74	O-linked_Glycosylation	PQQDPRLYWQGGPAL CCCCCCEEECCCCCC	9.28	55829353
84	Phosphorylation	GGPALGRSFLHGPEL CCCCCCCCCCCCCCC	30.29	20071362
93	Ubiquitination	LHGPELDKGQLRIHR CCCCCCCCCCEEECC	62.27	21906983
93	2-Hydroxyisobutyrylation	LHGPELDKGQLRIHR CCCCCCCCCCEEECC	62.27	-
93	Ubiquitination	LHGPELDKGQLRIHR CCCCCCCCCCEEECC	62.27	-
104	Phosphorylation	RIHRDGIYMVHIQVT EECCCCEEEEEEEEE	9.90	24732914
111	Phosphorylation	YMVHIQVTLAICSST EEEEEEEEEHHHCCC	8.29	24732914
116	Phosphorylation	QVTLAICSSTTASRH EEEEHHHCCCCCCCC	25.30	24732914
117	Phosphorylation	VTLAICSSTTASRHH EEEHHHCCCCCCCCC	25.93	24732914
118	Phosphorylation	TLAICSSTTASRHHP EEHHHCCCCCCCCCC	15.30	24732914
119	Phosphorylation	LAICSSTTASRHHPT EHHHCCCCCCCCCCC	25.28	24732914
121	Phosphorylation	ICSSTTASRHHPTTL HHCCCCCCCCCCCEE	30.01	24732914
133	S-palmitoylation	TTLAVGICSPASRSI CEEEEEEECHHHHHH	3.07	29575903
151	S-palmitoylation	RLSFHQGCTIASQRL HHEECCCCCCHHHCC	1.68	29575903
170	N-linked_Glycosylation	RGDTLCTNLTGTLLP CCCCEEECCCCCCCC	34.31	UniProtKB CARBOHYD
178	Phosphorylation	LTGTLLPSRNTDETF CCCCCCCCCCCCCCE	37.83	25278378

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD70_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD70_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD70_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CD27_HUMAN	CD27	physical	21917027
KDM8_HUMAN	KDM8	physical	28514442
S14L1_HUMAN	SEC14L1	physical	28514442
TAM41_HUMAN	TAMM41	physical	28514442
FANCG_HUMAN	FANCG	physical	28514442
NR2C2_HUMAN	NR2C2	physical	28514442
PDXD1_HUMAN	PDXDC1	physical	28514442
UTP20_HUMAN	UTP20	physical	28514442
XPO7_HUMAN	XPO7	physical	28514442
GPC5B_HUMAN	GPRC5B	physical	28514442
TBC20_HUMAN	TBC1D20	physical	28514442
MP2K3_HUMAN	MAP2K3	physical	28514442
PPTC7_HUMAN	PPTC7	physical	28514442
TBRG4_HUMAN	TBRG4	physical	28514442
MET15_HUMAN	METTL15	physical	28514442
INT2_HUMAN	INTS2	physical	28514442
ATRIP_HUMAN	ATRIP	physical	28514442
ATLA3_HUMAN	ATL3	physical	28514442
TTYH3_HUMAN	TTYH3	physical	28514442
TNPO3_HUMAN	TNPO3	physical	28514442
HUS1_HUMAN	HUS1	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
PDS5A_HUMAN	PDS5A	physical	28514442
GNL3L_HUMAN	GNL3L	physical	28514442
MIGA1_HUMAN	FAM73A	physical	28514442
TIM_HUMAN	TIMELESS	physical	28514442
DEP1A_HUMAN	DEPDC1	physical	28514442
INT4_HUMAN	INTS4	physical	28514442
ATM_HUMAN	ATM	physical	28514442
RUFY2_HUMAN	RUFY2	physical	28514442
DCNL5_HUMAN	DCUN1D5	physical	28514442
INT3_HUMAN	INTS3	physical	28514442
COT2_HUMAN	NR2F2	physical	28514442
GLMN_HUMAN	GLMN	physical	28514442
ZNT5_HUMAN	SLC30A5	physical	28514442
PLAP_HUMAN	PLAA	physical	28514442
RNBP6_HUMAN	RANBP6	physical	28514442
NOP9_HUMAN	NOP9	physical	28514442
IFRD1_HUMAN	IFRD1	physical	28514442
CHPT1_HUMAN	CHPT1	physical	28514442
PDS5B_HUMAN	PDS5B	physical	28514442
GXLT2_HUMAN	GXYLT2	physical	28514442
COT1_HUMAN	NR2F1	physical	28514442
UBE4A_HUMAN	UBE4A	physical	28514442
UBP22_HUMAN	USP22	physical	28514442
SYAM_HUMAN	AARS2	physical	28514442
COQ8B_HUMAN	ADCK4	physical	28514442
SYNM_HUMAN	NARS2	physical	28514442
SCAM1_HUMAN	SCAMP1	physical	28514442
COPT1_HUMAN	SLC31A1	physical	28514442
TFB2M_HUMAN	TFB2M	physical	28514442
EI2BG_HUMAN	EIF2B3	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
TTI1_HUMAN	TTI1	physical	28514442
NUP85_HUMAN	NUP85	physical	28514442
DYM_HUMAN	DYM	physical	28514442
NUP98_HUMAN	NUP98	physical	28514442
RUFY1_HUMAN	RUFY1	physical	28514442
HIP1R_HUMAN	HIP1R	physical	28514442
ORC5_HUMAN	ORC5	physical	28514442
IPO11_HUMAN	IPO11	physical	28514442
SPP2B_HUMAN	SPPL2B	physical	28514442
EXOC6_HUMAN	EXOC6	physical	28514442
INT5_HUMAN	INTS5	physical	28514442
NOL11_HUMAN	NOL11	physical	28514442
GLPK_HUMAN	GK	physical	28514442
MDN1_HUMAN	MDN1	physical	28514442
XPO4_HUMAN	XPO4	physical	28514442
PLCE_HUMAN	AGPAT5	physical	28514442
UCKL1_HUMAN	UCKL1	physical	28514442
STAG2_HUMAN	STAG2	physical	28514442
RBFA_HUMAN	RBFA	physical	28514442
MP2K2_HUMAN	MAP2K2	physical	28514442
NU160_HUMAN	NUP160	physical	28514442
TBB8_HUMAN	TUBB8	physical	28514442
NU107_HUMAN	NUP107	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D10341: Vorsetuzumab mafodotin (USAN/INN)
• D10342: Vorsetuzumab (USAN/INN)
• DrugBank
• There are no disease associations of PTM sites.