TRI14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI14_HUMAN
• UniProt AC: Q14142
• Protein Name: Tripartite motif-containing protein 14
• Gene Name: TRIM14
• Organism: Homo sapiens (Human).
• Sequence Length: 442
• Subcellular Localization: Mitochondrion outer membrane .
• Protein Description: Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. [PubMed: 24379373 Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation]
• Protein Sequence: MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGAHRGHPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSISQEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAGAATGSRTPGR --CCCCCCCCCCCCC	34.85	27251275
8	Phosphorylation	MAGAATGSRTPGRSE CCCCCCCCCCCCCHH	28.73	24719451
10	Phosphorylation	GAATGSRTPGRSELV CCCCCCCCCCCHHHC	31.62	21712546
14	Phosphorylation	GSRTPGRSELVEGCG CCCCCCCHHHCCCCC	40.99	21712546
70	Ubiquitination	EAAVHVQKLSQECLK HHHHHHHHHCHHHHH	49.36	-
72	Phosphorylation	AVHVQKLSQECLKQL HHHHHHHCHHHHHHH	30.85	26074081
77	Ubiquitination	KLSQECLKQLAIKKQ HHCHHHHHHHHHHHH	55.73	-
83	Ubiquitination	LKQLAIKKQQHIDNI HHHHHHHHHHHHHCC	49.42	-
99	Ubiquitination	QIEDATEKLKANAES HHHHHHHHHHHHHHH	51.43	-
108	Ubiquitination	KANAESSKTWLKGKF HHHHHHCCHHHHCCH	53.66	-
114	Ubiquitination	SKTWLKGKFTELRLL CCHHHHCCHHHHHHH	47.74	-
130	Ubiquitination	DEEEALAKKFIDKNT CHHHHHHHHHCCCCC	49.41	-
131	Ubiquitination	EEEALAKKFIDKNTQ HHHHHHHHHCCCCCC	41.78	-
135	Ubiquitination	LAKKFIDKNTQLTLQ HHHHHCCCCCCEEEH	58.01	-
139 (in isoform 4)	Phosphorylation	-	4.93	24114839
232	Ubiquitination	TPLDIRLKESINCQL CCCCCEEHHHHCCCC	39.30	-
246	Ubiquitination	LSDPSSTKPGTLLKT CCCCCCCCCCCEEEC	43.32	-
252	Ubiquitination	TKPGTLLKTSPSPER CCCCCEEECCCCHHH	50.50	-
264	Ubiquitination	PERSLLLKYARTPTL HHHHHHHHHCCCCCC	36.51	-
365	Ubiquitination	NRQSWCLKRYDLEYW CCCCHHCCCCCCEEE	45.86	-
371	Phosphorylation	LKRYDLEYWAFHDGQ CCCCCCEEEEEECCC	14.88	20049867
437	Phosphorylation	RLWEGAISIPRLP-- HHHCCCCCCCCCC--	26.46	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAVS_HUMAN	MAVS	physical	24379373
NEMO_HUMAN	IKBKG	physical	24379373

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.