dbPTM

ZN608_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN608_HUMAN
UniProt AC	Q9ULD9
Protein Name	Zinc finger protein 608
Gene Name	ZNF608
Organism	Homo sapiens (Human).
Sequence Length	1512
Subcellular Localization
Protein Description	Transcription factor, which represses ZNF609 transcription..
Protein Sequence	MSVNISTAGKGVDPNTVDTYDSGDDWEIGVGNLIIDLDADLEKDRQKFEMNNSTTTTSSSNSKDCGGPASSGAGATAALADGLKFASVQASAPQGNSHKETSKSKVKRSKTSKDANKSLPSAALYGIPEISSTGKRQEVQGRPGEATGMNSALGQSVSSGGSGNPNSNSTSTSTSAATAGAGSCGKSKEEKPGKSQSSRGAKRDKDAGKSRKDKHDLLQGHQNGSGSQAPSGGHLYGFGAKSNGGGASPFHCGGTGSGSVAAAGEVSKSAPDSGLMGNSMLVKKEEEEEESHRRIKKLKTEKVDPLFTVPAPPPPISSSLTPQILPSYFSPSSSNIAAPVEQLLVRTRSVGVNTCEVGVVTEPECLGPCEPGTSVNLEGIVWHETEEGVLVVNVTWRNKTYVGTLLDCTKHDWAPPRFCESPTSDLEMRGGRGRGKRARSAAAAPGSEASFTESRGLQNKNRGGANGKGRRGSLNASGRRTPPNCAAEDIKASPSSTNKRKNKPPMELDLNSSSEDNKPGKRVRTNSRSTPTTPQGKPETTFLDQGCSSPVLIDCPHPNCNKKYKHINGLRYHQAHAHLDPENKLEFEPDSEDKISDCEEGLSNVALECSEPSTSVSAYDQLKAPASPGAGNPPGTPKGKRELMSNGPGSIIGAKAGKNSGKKKGLNNELNNLPVISNMTAALDSCSAADGSLAAEMPKLEAEGLIDKKNLGDKEKGKKATNCKTDKNLSKLKSARPIAPAPAPTPPQLIAIPTATFTTTTTGTIPGLPSLTTTVVQATPKSPPLKPIQPKPTIMGEPITVNPALVSLKDKKKKEKRKLKDKEGKETGSPKMDAKLGKLEDSKGASKDLPGHFLKDHLNKNEGLANGLSESQESRMASIKAEADKVYTFTDNAPSPSIGSASRLECSTLVNGQAPMAPLHVLTQNGAESSAAKTSSPAYSDISDAADDGGSDSRSEGMRSKASSPSDIISSKDSVVKGHSSTTAQSSQLKESHSPYYHSYDPYYSPSYMHPGQVGAPAAGNSGSTQGMKIKKESEEDAEKKDKAEQLDSKKVDHNSASLQPQHQSVITQRHPALAQSLYYGQYAYGLYMDQKSLMATSPAYRQQYEKYYEDQRLAEQKMAQTGRGDCERKSELPLKELGKEETKQKNMPSATISKAPSTPEPNKNHSKLGPSVPNKTEETGKSQLLSNHQQQLQADSFKAKQMENHQLIKEAVEMKSVMDSMKQTGVDPTSRFKQDPDSRTWHHYVYQPKYLDQQKSEELDREKKLKEDSPRKTPNKESGVPSLPVSLTSIKEEPKEAKHPDSQSMEESKLKNDDRKTPVNWKDSRGTRVAVSSPMSQHQSYIQYLHAYPYPQMYDPSHPAYRAVSPVLMHSYPGAYLSPGFHYPVYGKMSGREETEKVNTSPSVNTKTTTESKALDLLQQHANQYRSKSPAPVEKATAEREREAERERDRHSPFGQRHLHTHHHTHVGMGYPLIPGQYDPFQGLTSAALVASQQVAAQASASGMFPGQRRE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVNISTAG ------CCCCCCCCC	34.86	21406692
6	Phosphorylation	--MSVNISTAGKGVD --CCCCCCCCCCCCC	13.65	21406692
7	Phosphorylation	-MSVNISTAGKGVDP -CCCCCCCCCCCCCC	35.32	21406692
53	Phosphorylation	QKFEMNNSTTTTSSS HHHCCCCCCCCCCCC	23.33	28985074
56	Phosphorylation	EMNNSTTTTSSSNSK CCCCCCCCCCCCCCC	25.43	28985074
58	Phosphorylation	NNSTTTTSSSNSKDC CCCCCCCCCCCCCCC	29.67	28985074
59	Phosphorylation	NSTTTTSSSNSKDCG CCCCCCCCCCCCCCC	31.29	-
60	Phosphorylation	STTTTSSSNSKDCGG CCCCCCCCCCCCCCC	44.91	28985074
71	Phosphorylation	DCGGPASSGAGATAA CCCCCCCCCHHHHHH	34.47	-
118	Phosphorylation	TSKDANKSLPSAALY CCHHHHHCCCHHHHH	45.37	22210691
131	Phosphorylation	LYGIPEISSTGKRQE HHCCCCCCCCCCCEE	21.86	22210691
248	Phosphorylation	KSNGGGASPFHCGGT CCCCCCCCCCCCCCC	31.23	22617229
269	Phosphorylation	AAGEVSKSAPDSGLM ECCCCCCCCCCCCCC	37.21	20068231
273	Phosphorylation	VSKSAPDSGLMGNSM CCCCCCCCCCCCCCE	32.54	20068231
279	Phosphorylation	DSGLMGNSMLVKKEE CCCCCCCCEEEEHHH	14.04	20068231
283	Sumoylation	MGNSMLVKKEEEEEE CCCCEEEEHHHHHHH	50.97	28112733
291	Phosphorylation	KEEEEEESHRRIKKL HHHHHHHHHHHHHHH	26.10	29514088
401	Phosphorylation	VTWRNKTYVGTLLDC EEECCCEEEEEEEEC	9.86	-
421	Phosphorylation	APPRFCESPTSDLEM CCCCCCCCCCCCCHH	34.36	23401153
423	Phosphorylation	PRFCESPTSDLEMRG CCCCCCCCCCCHHCC	44.12	29255136
424	Phosphorylation	RFCESPTSDLEMRGG CCCCCCCCCCHHCCC	43.51	29255136
440	Phosphorylation	GRGKRARSAAAAPGS CCCHHHHHHHCCCCC	22.67	29255136
447	Phosphorylation	SAAAAPGSEASFTES HHHCCCCCCCCCCCC	29.00	29978859
450	Phosphorylation	AAPGSEASFTESRGL CCCCCCCCCCCCCCC	28.75	29978859
452	Phosphorylation	PGSEASFTESRGLQN CCCCCCCCCCCCCCC	30.47	29978859
454	Phosphorylation	SEASFTESRGLQNKN CCCCCCCCCCCCCCC	28.70	29978859
471	Dimethylation	GANGKGRRGSLNASG CCCCCCCCCCCCCCC	47.96	-
471	Methylation	GANGKGRRGSLNASG CCCCCCCCCCCCCCC	47.96	54549231
473	Phosphorylation	NGKGRRGSLNASGRR CCCCCCCCCCCCCCC	19.35	28857561
477	Phosphorylation	RRGSLNASGRRTPPN CCCCCCCCCCCCCCC	31.59	23898821
481	Phosphorylation	LNASGRRTPPNCAAE CCCCCCCCCCCCCHH	41.56	23401153
493	Phosphorylation	AAEDIKASPSSTNKR CHHHHCCCCCCCCCC	21.95	28985074
495	Phosphorylation	EDIKASPSSTNKRKN HHHCCCCCCCCCCCC	47.50	27732954
496	Phosphorylation	DIKASPSSTNKRKNK HHCCCCCCCCCCCCC	39.11	27732954
497	Phosphorylation	IKASPSSTNKRKNKP HCCCCCCCCCCCCCC	49.44	27732954
512	Phosphorylation	PMELDLNSSSEDNKP CCCCCCCCCCCCCCC	42.40	20363803
513	Phosphorylation	MELDLNSSSEDNKPG CCCCCCCCCCCCCCC	36.35	20363803
514	Phosphorylation	ELDLNSSSEDNKPGK CCCCCCCCCCCCCCC	49.11	27732954
525	Phosphorylation	KPGKRVRTNSRSTPT CCCCCEECCCCCCCC	34.39	30266825
527	Phosphorylation	GKRVRTNSRSTPTTP CCCEECCCCCCCCCC	27.31	30266825
529	Phosphorylation	RVRTNSRSTPTTPQG CEECCCCCCCCCCCC	38.26	30266825
530	Phosphorylation	VRTNSRSTPTTPQGK EECCCCCCCCCCCCC	24.44	30266825
532	Phosphorylation	TNSRSTPTTPQGKPE CCCCCCCCCCCCCCC	51.72	27251275
533	Phosphorylation	NSRSTPTTPQGKPET CCCCCCCCCCCCCCC	18.15	30266825
540	Phosphorylation	TPQGKPETTFLDQGC CCCCCCCCCCCCCCC	31.23	25002506
541	Phosphorylation	PQGKPETTFLDQGCS CCCCCCCCCCCCCCC	22.12	27251275
548	Phosphorylation	TFLDQGCSSPVLIDC CCCCCCCCCCEEECC	44.49	25850435
549	Phosphorylation	FLDQGCSSPVLIDCP CCCCCCCCCEEECCC	24.09	25850435
591	Phosphorylation	KLEFEPDSEDKISDC CCCCCCCCCCCHHHH	59.41	26471730
596	Phosphorylation	PDSEDKISDCEEGLS CCCCCCHHHHHHHHH	41.78	26471730
603	Phosphorylation	SDCEEGLSNVALECS HHHHHHHHCEEEECC	39.86	26471730
610	Phosphorylation	SNVALECSEPSTSVS HCEEEECCCCCCCCC	43.07	26471730
613	Phosphorylation	ALECSEPSTSVSAYD EEECCCCCCCCCHHH	29.30	26471730
614	Phosphorylation	LECSEPSTSVSAYDQ EECCCCCCCCCHHHH	43.81	26471730
615	Phosphorylation	ECSEPSTSVSAYDQL ECCCCCCCCCHHHHH	20.57	26471730
617	Phosphorylation	SEPSTSVSAYDQLKA CCCCCCCCHHHHHCC	22.37	26471730
619	Phosphorylation	PSTSVSAYDQLKAPA CCCCCCHHHHHCCCC	9.19	26471730
627	Phosphorylation	DQLKAPASPGAGNPP HHHCCCCCCCCCCCC	23.86	30266825
636	Phosphorylation	GAGNPPGTPKGKREL CCCCCCCCCCCHHHH	27.83	30266825
645	Phosphorylation	KGKRELMSNGPGSII CCHHHHHHCCCCCEE	51.78	23312004
650	Phosphorylation	LMSNGPGSIIGAKAG HHHCCCCCEEEHHCC	17.73	23312004
655	Acetylation	PGSIIGAKAGKNSGK CCCEEEHHCCCCCCC	53.08	18529917
660	Phosphorylation	GAKAGKNSGKKKGLN EHHCCCCCCCCCCCC	56.31	23312004
724	Acetylation	GKKATNCKTDKNLSK CCCCCCCCCCCCHHH	62.92	24846379
730	Phosphorylation	CKTDKNLSKLKSARP CCCCCCHHHHHCCCC	45.39	24719451
782	Phosphorylation	VVQATPKSPPLKPIQ EEECCCCCCCCCCCC	32.71	30266825
793	Phosphorylation	KPIQPKPTIMGEPIT CCCCCCCCCCCCCCE	29.71	25002506
823 (in isoform 2)	Ubiquitination	-	82.63	21890473
827	Phosphorylation	KDKEGKETGSPKMDA CCCCCCCCCCHHHHH	46.58	22985185
829	Phosphorylation	KEGKETGSPKMDAKL CCCCCCCCHHHHHHH	28.85	30387612
838	Ubiquitination	KMDAKLGKLEDSKGA HHHHHHCCCCCCCCC	60.17	-
847	Ubiquitination	EDSKGASKDLPGHFL CCCCCCCCCCCHHHH	63.85	-
871	Phosphorylation	LANGLSESQESRMAS HHCCCCHHHHHHHHH	35.55	17525332
874	Phosphorylation	GLSESQESRMASIKA CCCHHHHHHHHHHHH	21.51	26714015
880	Sumoylation	ESRMASIKAEADKVY HHHHHHHHHHHCEEE	37.36	28112733
887	Phosphorylation	KAEADKVYTFTDNAP HHHHCEEEEECCCCC	11.24	29255136
888	Phosphorylation	AEADKVYTFTDNAPS HHHCEEEEECCCCCC	24.05	29255136
890	Phosphorylation	ADKVYTFTDNAPSPS HCEEEEECCCCCCCC	22.12	29255136
895	Phosphorylation	TFTDNAPSPSIGSAS EECCCCCCCCCCCCC	28.95	23401153
897	Phosphorylation	TDNAPSPSIGSASRL CCCCCCCCCCCCCCE	43.87	30266825
900	Phosphorylation	APSPSIGSASRLECS CCCCCCCCCCCEEEH	22.77	29255136
902	Phosphorylation	SPSIGSASRLECSTL CCCCCCCCCEEEHHH	38.81	29255136
934	Phosphorylation	AESSAAKTSSPAYSD CCCCCCCCCCCCCCC	29.70	30108239
935	Phosphorylation	ESSAAKTSSPAYSDI CCCCCCCCCCCCCCH	33.35	30108239
936	Phosphorylation	SSAAKTSSPAYSDIS CCCCCCCCCCCCCHH	20.84	30108239
939	Phosphorylation	AKTSSPAYSDISDAA CCCCCCCCCCHHHHC	15.40	30108239
940	Phosphorylation	KTSSPAYSDISDAAD CCCCCCCCCHHHHCC	30.49	30108239
943	Phosphorylation	SPAYSDISDAADDGG CCCCCCHHHHCCCCC	26.62	18452278
951	Phosphorylation	DAADDGGSDSRSEGM HHCCCCCCCCHHHHH	37.63	27732954
953	Phosphorylation	ADDGGSDSRSEGMRS CCCCCCCCHHHHHHC	39.13	27732954
960	Phosphorylation	SRSEGMRSKASSPSD CHHHHHHCCCCCHHH	24.55	27732954
963	Phosphorylation	EGMRSKASSPSDIIS HHHHCCCCCHHHHHC	46.66	30266825
964	Phosphorylation	GMRSKASSPSDIISS HHHCCCCCHHHHHCC	33.03	19664994
966	Phosphorylation	RSKASSPSDIISSKD HCCCCCHHHHHCCCC	43.31	30266825
970	Phosphorylation	SSPSDIISSKDSVVK CCHHHHHCCCCCCCC	31.50	23403867
971	Phosphorylation	SPSDIISSKDSVVKG CHHHHHCCCCCCCCC	30.03	23403867
974	Phosphorylation	DIISSKDSVVKGHSS HHHCCCCCCCCCCCC	32.33	23312004
981	Phosphorylation	SVVKGHSSTTAQSSQ CCCCCCCCCCCCHHH	24.89	-
1003	Phosphorylation	YYHSYDPYYSPSYMH CCCCCCCCCCCCCCC	17.43	22798277
1097	Phosphorylation	DQKSLMATSPAYRQQ CHHHHHHCCHHHHHH	22.68	27732954
1098	Phosphorylation	QKSLMATSPAYRQQY HHHHHHCCHHHHHHH	9.67	28112733
1101	Phosphorylation	LMATSPAYRQQYEKY HHHCCHHHHHHHHHH	16.61	27732954
1118	Sumoylation	DQRLAEQKMAQTGRG HHHHHHHHHHHCCCC	27.92	28112733
1143	Phosphorylation	KELGKEETKQKNMPS HHHCHHHHHHHCCCC	39.61	-
1150	Phosphorylation	TKQKNMPSATISKAP HHHHCCCCCCCCCCC	27.55	22985185
1152	Phosphorylation	QKNMPSATISKAPST HHCCCCCCCCCCCCC	30.07	-
1154	Phosphorylation	NMPSATISKAPSTPE CCCCCCCCCCCCCCC	20.57	-
1158	Phosphorylation	ATISKAPSTPEPNKN CCCCCCCCCCCCCCC	62.55	28348404
1159	Phosphorylation	TISKAPSTPEPNKNH CCCCCCCCCCCCCCC	30.52	27251275
1176	Sumoylation	LGPSVPNKTEETGKS CCCCCCCCCHHHCHH	51.77	28112733
1182	Sumoylation	NKTEETGKSQLLSNH CCCHHHCHHHHHHHH	42.31	28112733
1199	Sumoylation	QLQADSFKAKQMENH HHHHHHHHHHHHHHH	59.64	28112733
1216	Sumoylation	IKEAVEMKSVMDSMK HHHHHHHHHHHHHHH	26.79	28112733
1234	Sumoylation	VDPTSRFKQDPDSRT CCCCCCCCCCCCCCC	53.32	28112733
1239	Phosphorylation	RFKQDPDSRTWHHYV CCCCCCCCCCCCEEE	36.68	-
1250	Ubiquitination	HHYVYQPKYLDQQKS CEEECCCHHHCHHHH	42.81	21890473
1250	Sumoylation	HHYVYQPKYLDQQKS CEEECCCHHHCHHHH	42.81	28112733
1250 (in isoform 1)	Ubiquitination	-	42.81	21890473
1283	Phosphorylation	NKESGVPSLPVSLTS CCCCCCCCCCCCHHC	42.79	-
1292	Sumoylation	PVSLTSIKEEPKEAK CCCHHCCCCCCCCCC	56.65	28112733
1309	Phosphorylation	DSQSMEESKLKNDDR CCCCHHHHHCCCCCC	29.95	-
1310	Sumoylation	SQSMEESKLKNDDRK CCCHHHHHCCCCCCC	67.75	28112733
1318	Phosphorylation	LKNDDRKTPVNWKDS CCCCCCCCCCCCCCC	33.10	23403867
1366	Phosphorylation	HPAYRAVSPVLMHSY CHHHHCCCCCHHCCC	14.33	27251275
1396	Phosphorylation	KMSGREETEKVNTSP CCCCCCCCCCCCCCC	36.03	29083192
1401	Phosphorylation	EETEKVNTSPSVNTK CCCCCCCCCCCCCCC	45.03	27732954
1402	Phosphorylation	ETEKVNTSPSVNTKT CCCCCCCCCCCCCCC	15.24	27732954
1404	Phosphorylation	EKVNTSPSVNTKTTT CCCCCCCCCCCCCCC	27.97	27251275
1407	Phosphorylation	NTSPSVNTKTTTESK CCCCCCCCCCCCHHH	27.84	29083192
1414	Sumoylation	TKTTTESKALDLLQQ CCCCCHHHHHHHHHH	46.89	28112733
1428	Phosphorylation	QHANQYRSKSPAPVE HHHHHHHCCCCCCHH	32.33	22798277
1430	Phosphorylation	ANQYRSKSPAPVEKA HHHHHCCCCCCHHHH	27.78	28985074
1453	Phosphorylation	ERERDRHSPFGQRHL HHHHHCCCCCCCCCC	23.87	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN608_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN608_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN608_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZN608_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN608_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-627 AND THR-636, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-871, AND MASSSPECTROMETRY.	17525332 [Abstract]