ELF3_HUMAN - dbPTM
ELF3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ELF3_HUMAN
UniProt AC P78545
Protein Name ETS-related transcription factor Elf-3
Gene Name ELF3 {ECO:0000312|HGNC:HGNC:3318}
Organism Homo sapiens (Human).
Sequence Length 371
Subcellular Localization Cytoplasm . Nucleus . Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transf
Protein Description Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity)..
Protein Sequence MAATCEISNIFSNYFSAMYSSEDSTLASVPPAATFGADDLVLTLSNPQMSLEGTEKASWLGEQPQFWSKTQVLDWISYQVEKNKYDASAIDFSRCDMDGATLCNCALEELRLVFGPLGDQLHAQLRDLTSSSSDELSWIIELLEKDGMAFQEALDPGPFDQGSPFAQELLDDGQQASPYHPGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSDGFRDCKKGDPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVLQSRN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
58PhosphorylationLEGTEKASWLGEQPQ
CCCCCCCHHCCCCCC		33.6228348404
68PhosphorylationGEQPQFWSKTQVLDW
CCCCCCCCHHHHHHH		27.41-
82UbiquitinationWISYQVEKNKYDASA
HHHHHHHHCCCCCCC		60.9421906983
82 (in isoform 2)Ubiquitination-60.9421906983
82 (in isoform 1)Ubiquitination-60.9421906983
84UbiquitinationSYQVEKNKYDASAID
HHHHHHCCCCCCCCC		56.4221906983
84 (in isoform 1)Ubiquitination-56.4221906983
84 (in isoform 2)Ubiquitination-56.4221906983
137PhosphorylationSSSSDELSWIIELLE
CCCHHHHHHHHHHHH		17.7428348404
183 (in isoform 2)Phosphorylation-17.5227762562
184 (in isoform 2)Phosphorylation-5.5527762562
206PhosphorylationAGTGASRSSHSSDSG
CCCCCCCCCCCCCCC		29.8823663014
207PhosphorylationGTGASRSSHSSDSGG
CCCCCCCCCCCCCCC		26.6917491012
209PhosphorylationGASRSSHSSDSGGSD
CCCCCCCCCCCCCCC		37.4823663014
210PhosphorylationASRSSHSSDSGGSDV
CCCCCCCCCCCCCCC		30.3023663014
212PhosphorylationRSSHSSDSGGSDVDL
CCCCCCCCCCCCCCC		47.1828355574
215PhosphorylationHSSDSGGSDVDLDPT
CCCCCCCCCCCCCCC		37.6828355574
222PhosphorylationSDVDLDPTDGKLFPS
CCCCCCCCCCCCCCC		57.9828176443
254PhosphorylationRGRPRKLSKEYWDCL
CCCCCCCCHHHHHHH		26.8625394399
257PhosphorylationPRKLSKEYWDCLEGK
CCCCCHHHHHHHCCC		15.4130576142
264UbiquitinationYWDCLEGKKSKHAPR
HHHHHCCCCCCCCCC		44.49-
271 (in isoform 2)Ubiquitination-64.5221906983
294 (in isoform 1)Ubiquitination-57.3021906983
294UbiquitinationELNEGLMKWENRHEG
HHCCCHHHCCCCCHH		57.3021906983
295 (in isoform 2)Ubiquitination-8.3021906983
304AcetylationNRHEGVFKFLRSEAV
CCCHHHHHHHHHHHH		40.8730588473
305 (in isoform 2)Ubiquitination-4.6821906983
308PhosphorylationGVFKFLRSEAVAQLW
HHHHHHHHHHHHHHH		31.86-
318"N6,N6-dimethyllysine"VAQLWGQKKKNSNMT
HHHHHCCCCCCCCCC		62.87-
318UbiquitinationVAQLWGQKKKNSNMT
HHHHHCCCCCCCCCC		62.8721906983
318MethylationVAQLWGQKKKNSNMT
HHHHHCCCCCCCCCC		62.87-
318 (in isoform 1)Ubiquitination-62.8721906983
319"N6,N6-dimethyllysine"AQLWGQKKKNSNMTY
HHHHCCCCCCCCCCH		49.66-
319MethylationAQLWGQKKKNSNMTY
HHHHCCCCCCCCCCH		49.66-
320MethylationQLWGQKKKNSNMTYE
HHHCCCCCCCCCCHH		73.05-
320"N6,N6-dimethyllysine"QLWGQKKKNSNMTYE
HHHCCCCCCCCCCHH		73.05-
322PhosphorylationWGQKKKNSNMTYEKL
HCCCCCCCCCCHHHH		36.5429396449
325PhosphorylationKKKNSNMTYEKLSRA
CCCCCCCCHHHHHHH		32.5529396449
326PhosphorylationKKNSNMTYEKLSRAM
CCCCCCCHHHHHHHH		10.5729396449
328UbiquitinationNSNMTYEKLSRAMRY
CCCCCHHHHHHHHHH		41.1521906983
328 (in isoform 1)Ubiquitination-41.1521906983
333 (in isoform 2)Ubiquitination-2.4821906983
339 (in isoform 2)Ubiquitination-21.7721906983
356 (in isoform 1)Ubiquitination-57.7121906983
356UbiquitinationRLVYKFGKNSSGWKE
EEEEECCCCCCCCCH		57.7121906983
362 (in isoform 1)Ubiquitination-59.7921906983
362UbiquitinationGKNSSGWKEEEVLQS
CCCCCCCCHHHHHHC		59.792190698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
68SPhosphorylationKinasePRKCIP41743
GPS
207SPhosphorylationKinasePAK1Q13153
PSP
-KUbiquitinationE3 ubiquitin ligaseBTRCQ9Y297
PMID:24658274
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ELF3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ELF3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDIA1_HUMANP4HBphysical
17353931
DDX3X_HUMANDDX3Xphysical
17353931
GANAB_HUMANGANABphysical
17353931
EHF_HUMANEHFphysical
17353931
PUR9_HUMANATICphysical
17353931
K1H1_HUMANKRT31physical
17353931
SYTC_HUMANTARSphysical
17353931
ISG15_HUMANISG15physical
17353931
CALR_HUMANCALRphysical
17353931
KRT82_HUMANKRT82physical
17353931
EF1D_HUMANEEF1Dphysical
17353931
JAK1_HUMANJAK1physical
17353931
NFKB1_HUMANNFKB1physical
11036073
MED23_HUMANMED23physical
12242338
ERBB2_HUMANERBB2genetic
12242338
TBP_HUMANTBPphysical
10391676
TAF9_HUMANTAF9physical
10821850
FBW1A_HUMANBTRCphysical
17491012
MYC_HUMANMYCphysical
1651323
JUN_RATJunphysical
1651323
EP300_HUMANEP300physical
15075319
XRCC6_HUMANXRCC6physical
15075319
XRCC5_HUMANXRCC5physical
15075319
RL6_HUMANRPL6physical
15075319
CBR3_HUMANCBR3physical
15075319
MED23_HUMANMED23physical
12708845
MED23_HUMANMED23genetic
12242338
NFKB1_HUMANNFKB1physical
23687337
TF65_HUMANRELAphysical
23687337
ANDR_HUMANARphysical
23435425
ELF3_HUMANELF3physical
17148437
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ELF3_HUMAN

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Related Literatures of Post-Translational Modification

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