CETN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CETN1_HUMAN
• UniProt AC: Q12798
• Protein Name: Centrin-1
• Gene Name: CETN1
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Centrosome of interphase and mitotic cells.
• Protein Description: Plays a fundamental role in microtubule-organizing center structure and function. [PubMed: 8175926 Plays a role in sperm cilia formation (By similarity]
• Protein Sequence: MASGFKKPSAASTGQKRKVAPKPELTEDQKQEVREAFDLFDVDGSGTIDAKELKVAMRALGFEPRKEEMKKMISEVDREGTGKISFNDFLAVMTQKMSEKDTKEEILKAFRLFDDDETGKISFKNLKRVANELGENLTDEELQEMIDEADRDGDGEVNEEEFLRIMKKTSLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGFKKPS ------CCCCCCCCC	20.54	-
9	Phosphorylation	ASGFKKPSAASTGQK CCCCCCCCCCCCCCC	45.40	-
26	Phosphorylation	VAPKPELTEDQKQEV CCCCCCCCHHHHHHH	35.53	-
54	Ubiquitination	TIDAKELKVAMRALG CCCHHHHHHHHHHCC	29.10	-
103	Ubiquitination	KMSEKDTKEEILKAF HCCCCCCHHHHHHHH	64.58	-
120	Ubiquitination	FDDDETGKISFKNLK CCCCCCCCCCHHHHH	42.47	-
122	Phosphorylation	DDETGKISFKNLKRV CCCCCCCCHHHHHHH	33.38	24719451
124	Ubiquitination	ETGKISFKNLKRVAN CCCCCCHHHHHHHHH	55.36	21890473
124	2-Hydroxyisobutyrylation	ETGKISFKNLKRVAN CCCCCCHHHHHHHHH	55.36	-
127	Ubiquitination	KISFKNLKRVANELG CCCHHHHHHHHHHHH	54.97	-
138	Phosphorylation	NELGENLTDEELQEM HHHHCCCCHHHHHHH	53.60	-
170	Phosphorylation	LRIMKKTSLY----- HHHHHHHCCC-----	34.25	11279195

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
138	T	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
170	S	Phosphorylation	Kinase	AURKA	O14965	GPS
170	S	Phosphorylation	Kinase	PKACA	P00517	PSP
170	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
170	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CETN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CETN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP110_HUMAN	CCP110	physical	16760425
BRCA1_HUMAN	BRCA1	physical	22833046
SGSM1_HUMAN	SGSM1	physical	25416956
POC5_HUMAN	POC5	physical	25416956
XPC_HUMAN	XPC	physical	28514442
POC5_HUMAN	POC5	physical	28514442
SGSM1_HUMAN	SGSM1	physical	28514442
CC191_HUMAN	KIAA1407	physical	28514442
SFI1_HUMAN	SFI1	physical	28514442
SGSM2_HUMAN	SGSM2	physical	28514442
EFC11_HUMAN	EFCAB11	physical	28514442
KIF1A_HUMAN	KIF1A	physical	28514442
TYDP1_HUMAN	TDP1	physical	28514442
FBX16_HUMAN	FBXO16	physical	28514442
KIF1B_HUMAN	KIF1B	physical	28514442
CETN2_HUMAN	CETN2	physical	28514442
TWST1_HUMAN	TWIST1	physical	28514442
DAAF4_HUMAN	DYX1C1	physical	28514442
PKN2_HUMAN	PKN2	physical	28514442
SPRY3_HUMAN	SPRYD3	physical	28514442
LHX4_HUMAN	LHX4	physical	28514442
TTF2_HUMAN	TTF2	physical	28514442
SH3B4_HUMAN	SH3BP4	physical	28514442
DYH14_HUMAN	DNAH14	physical	28514442
CETN3_HUMAN	CETN3	physical	28514442
VIP2_HUMAN	PPIP5K2	physical	28514442
MYCB2_HUMAN	MYCBP2	physical	28514442
GANP_HUMAN	MCM3AP	physical	28514442
LDB1_HUMAN	LDB1	physical	28514442
PARP2_HUMAN	PARP2	physical	28514442
CCHCR_HUMAN	CCHCR1	physical	28514442
RABP1_HUMAN	CRABP1	physical	28514442
ZBT21_HUMAN	ZBTB21	physical	28514442
SP16H_HUMAN	SUPT16H	physical	28514442
FBXW8_HUMAN	FBXW8	physical	28514442
H2AX_HUMAN	H2AFX	physical	28514442
BCKD_HUMAN	BCKDK	physical	28514442
PCID2_HUMAN	PCID2	physical	28514442
DEFM_HUMAN	PDF	physical	28514442
CUL7_HUMAN	CUL7	physical	28514442
CTU1_HUMAN	CTU1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.