SGSM1_HUMAN - dbPTM
SGSM1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SGSM1_HUMAN
UniProt AC Q2NKQ1
Protein Name Small G protein signaling modulator 1
Gene Name SGSM1
Organism Homo sapiens (Human).
Sequence Length 1148
Subcellular Localization Golgi apparatus, trans-Golgi network . Cytoplasmic vesicle membrane
Peripheral membrane protein . Cytoplasm . Recruited to cytoplasmic vesicle membranes via its interaction with Rab family members, such as RAB9A.
Protein Description Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B..
Protein Sequence MASAPAEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQENVRKLPKLPNLSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVDGPILASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKRHSSGSMDDRPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWTPNQLMNGSVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSAESTSSDKDDDEATDYVFRIIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTPSPKEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLHSDSSSSTQVFESVDEVEQVEAEGRLEEKQPKIPNGNLVNGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANESMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTSANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationSAPAEAETRQRLLRT
CCCCHHHHHHHHHHH		38.8730631047
67PhosphorylationRAAGFLRSNKIAALF
HHHHHHHHCHHHHHH		44.62-
154PhosphorylationLVENSSKYYEKEALL
HHHCCCCCCCHHHHC		20.85-
155PhosphorylationVENSSKYYEKEALLM
HHCCCCCCCHHHHCC		25.02-
172PhosphorylationVDGPILASLLVGPCA
CCCHHHHHHHHHHHH		20.84-
182PhosphorylationVGPCALEYTKMKTAD
HHHHHHHHCCCCCCC		16.71-
183PhosphorylationGPCALEYTKMKTADH
HHHHHHHCCCCCCCC		18.45-
229PhosphorylationLCIQKRHSSGSMDDR
EEEEECCCCCCCCCC		40.1923312004
230PhosphorylationCIQKRHSSGSMDDRP
EEEECCCCCCCCCCC		28.8523312004
232PhosphorylationQKRHSSGSMDDRPSL
EECCCCCCCCCCCCC		22.4628348404
266 (in isoform 3)Phosphorylation-24.1322210691
300PhosphorylationPNQLMNGSVGDLDYE
HHHHHCCCCCCCCHH		20.2328348404
397PhosphorylationFPKLRKRSPQGSAES
CHHHCCCCCCCCCCC		25.3028985074
401PhosphorylationRKRSPQGSAESTSSD
CCCCCCCCCCCCCCC		24.5026657352
477PhosphorylationRWDTTLPTPSPKEQP
CCCCCCCCCCCCCCC		39.2424719451
509PhosphorylationWQPSPRKSSCSSCSQ
CCCCCCCCCCCCCCC		37.5427251275
510PhosphorylationQPSPRKSSCSSCSQS
CCCCCCCCCCCCCCC		22.5127251275
512PhosphorylationSPRKSSCSSCSQSGS
CCCCCCCCCCCCCCC		36.0127251275
513PhosphorylationPRKSSCSSCSQSGSA
CCCCCCCCCCCCCCC		23.3230576142
515PhosphorylationKSSCSSCSQSGSADG
CCCCCCCCCCCCCCC		29.3627251275
517PhosphorylationSCSSCSQSGSADGSS
CCCCCCCCCCCCCCC		20.5830576142
684PhosphorylationAAALAKCSSGASLDS
HHHHHHCCCCCCHHH		30.9723312004
685PhosphorylationAALAKCSSGASLDSH
HHHHHCCCCCCHHHH		48.0926657352
688PhosphorylationAKCSSGASLDSHLHR
HHCCCCCCHHHHHHH		35.9123312004
691PhosphorylationSSGASLDSHLHRMLH
CCCCCHHHHHHHHHH		32.9923312004
701PhosphorylationHRMLHRDSTISNESS
HHHHHCCCCCCCCCC		27.8323312004
702PhosphorylationRMLHRDSTISNESSQ
HHHHCCCCCCCCCCC		32.4923312004
704PhosphorylationLHRDSTISNESSQSC
HHCCCCCCCCCCCCC		34.3328348404
950PhosphorylationVQRCDRNYWYFTPAN
HHHCCCCCEEECHHH		11.4629978859
952PhosphorylationRCDRNYWYFTPANLE
HCCCCCEEECHHHHH		6.2929978859
954PhosphorylationDRNYWYFTPANLEKL
CCCCEEECHHHHHHH		13.0429978859
1021PhosphorylationPHGGAMDTHFANMRS
CCCCCHHHHHHHHHH		13.05-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SGSM1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SGSM1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SGSM1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SGSM1_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SGSM1_HUMAN

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Related Literatures of Post-Translational Modification

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