SGSM2_HUMAN - dbPTM
SGSM2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SGSM2_HUMAN
UniProt AC O43147
Protein Name Small G protein signaling modulator 2
Gene Name SGSM2
Organism Homo sapiens (Human).
Sequence Length 1006
Subcellular Localization Cytoplasm . Melanosome . Melanosomal localization is mediated by RAB9A.
Protein Description Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. [PubMed: 26620560]
Protein Sequence MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGEICHKVQELQQQAEGRKPSGVSQEALRRQGSASGKAPALSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRHSSGSASEDRLAACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVFPKLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHNAGDMIEMQGFGPSLPAWHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCESMKRQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKELELLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRLIHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGPGTPGTAVVEQQHSVEFDSPDSGLPSSRNYSVASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQDPSQEKPQAGELEAGEELAAVCAAAYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDFTDIIKFFNERAEHHDAQEILRIARDLVHKVQMLIENK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
100UbiquitinationQQQAEGRKPSGVSQE
HHHHCCCCCCCCCHH		55.16-
102PhosphorylationQAEGRKPSGVSQEAL
HHCCCCCCCCCHHHH		55.6627174698
105PhosphorylationGRKPSGVSQEALRRQ
CCCCCCCCHHHHHHC		26.3127174698
114PhosphorylationEALRRQGSASGKAPA
HHHHHCCCCCCCCCC		15.7827174698
116PhosphorylationLRRQGSASGKAPALS
HHHCCCCCCCCCCCC		42.3927174698
123PhosphorylationSGKAPALSPQALKHV
CCCCCCCCHHHHHHH		19.6425159151
187UbiquitinationALEYTKLKTADHYWT
HHHHHCCCCCCCCCC		43.13-
216PhosphorylationGPPTRQDSPAKRPAL
CCCCCCCCCCCCCCC		20.5824719451
230PhosphorylationLGIRKRHSSGSASED
CCCCCCCCCCCCCHH		40.1923312004
231PhosphorylationGIRKRHSSGSASEDR
CCCCCCCCCCCCHHH		30.5529449344
233PhosphorylationRKRHSSGSASEDRLA
CCCCCCCCCCHHHHH		30.4823312004
235PhosphorylationRHSSGSASEDRLAAC
CCCCCCCCHHHHHHH		41.5526546556
288PhosphorylationSLHQSAESLTLKWTP
HHHHCCCHHCCCCCC		26.7724719451
398PhosphorylationFPKLRKRSSIRSVDM
CHHHHCCCCCCCCCH		32.9028348404
399PhosphorylationPKLRKRSSIRSVDME
HHHHCCCCCCCCCHH		26.5022617229
402PhosphorylationRKRSSIRSVDMEEMG
HCCCCCCCCCHHHHC		22.3122617229
412MethylationMEEMGTGRATDYVFR
HHHHCCCCCCEEEEE		33.8724380707
412DimethylationMEEMGTGRATDYVFR
HHHHCCCCCCEEEEE		33.87-
419DimethylationRATDYVFRIIYPGHR
CCCEEEEEEECCCCC		12.35-
419MethylationRATDYVFRIIYPGHR
CCCEEEEEEECCCCC		12.3524380717
444 (in isoform 2)Phosphorylation-3.6424719451
460 (in isoform 2)Phosphorylation-6.63-
492UbiquitinationRLLCESMKRQIVSRA
HHHHHHHHHHHHHHH		50.89-
545UbiquitinationLTKDVWSKYQKDKKN
CCHHHHHHHHHHCCC		35.67-
554UbiquitinationQKDKKNYKELELLRQ
HHHCCCHHHHHHHHH		66.28-
590AcetylationYKFGMSKKEMEQVDA
HHCCCCHHHHHHHHH		55.7920167786
611AcetylationQQVLAEWKACEVVVR
HHHHHHHHHCHHHHH		34.3620167786
628PhosphorylationEREAHPATRTKFSSG
HHHCCCCCCCCCCCC		43.2427966365
630PhosphorylationEAHPATRTKFSSGSS
HCCCCCCCCCCCCCC		31.8923090842
631UbiquitinationAHPATRTKFSSGSSI
CCCCCCCCCCCCCCH		39.70-
633PhosphorylationPATRTKFSSGSSIDS
CCCCCCCCCCCCHHH		35.0328450419
634PhosphorylationATRTKFSSGSSIDSH
CCCCCCCCCCCHHHH		45.9128450419
636PhosphorylationRTKFSSGSSIDSHVQ
CCCCCCCCCHHHHHH		26.5228450419
637PhosphorylationTKFSSGSSIDSHVQR
CCCCCCCCHHHHHHH		33.6628450419
640PhosphorylationSSGSSIDSHVQRLIH
CCCCCHHHHHHHHHH		24.7227732954
979 (in isoform 5)Phosphorylation-46.5126270265
980 (in isoform 5)Phosphorylation-17.8126270265
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SGSM2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SGSM2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SGSM2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FETA_HUMANAFPphysical
16169070
CELR3_HUMANCELSR3physical
16169070
ILF2_MOUSEIlf2physical
16169070
KHDR3_HUMANKHDRBS3physical
16169070
RGMA_HUMANRGMAphysical
16169070
RS25_HUMANRPS25physical
16169070
CAH12_HUMANCA12physical
16169070
CHD3_HUMANCHD3physical
16169070
EGFR_HUMANEGFRphysical
16169070
GDPD2_HUMANGDPD2physical
16169070
PNO1_HUMANPNO1physical
16169070
EM55_HUMANMPP1physical
16169070
FBP1L_HUMANFNBP1Lphysical
16169070
PTN_HUMANPTNphysical
16169070
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SGSM2_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory