FETA_HUMAN - dbPTM
FETA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FETA_HUMAN
UniProt AC P02771
Protein Name Alpha-fetoprotein
Gene Name AFP
Organism Homo sapiens (Human).
Sequence Length 609
Subcellular Localization Secreted.
Protein Description Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties..
Protein Sequence MKWVESIFLIFLLNFTESRTLHRNEYGIASILDSYQCTAEISLADLATIFFAQFVQEATYKEVSKMVKDALTAIEKPTGDEQSSGCLENQLPAFLEELCHEKEILEKYGHSDCCSQSEEGRHNCFLAHKKPTPASIPLFQVPEPVTSCEAYEEDRETFMNKFIYEIARRHPFLYAPTILLWAARYDKIIPSCCKAENAVECFQTKAATVTKELRESSLLNQHACAVMKNFGTRTFQAITVTKLSQKFTKVNFTEIQKLVLDVAHVHEHCCRGDVLDCLQDGEKIMSYICSQQDTLSNKITECCKLTTLERGQCIIHAENDEKPEGLSPNLNRFLGDRDFNQFSSGEKNIFLASFVHEYSRRHPQLAVSVILRVAKGYQELLEKCFQTENPLECQDKGEEELQKYIQESQALAKRSCGLFQKLGEYYLQNAFLVAYTKKAPQLTSSELMAITRKMAATAATCCQLSEDKLLACGEGAADIIIGHLCIRHEMTPVNPGVGQCCTSSYANRRPCFSSLVVDETYVPPAFSDDKFIFHKDLCQAQGVALQTMKQEFLINLVKQKPQITEEQLEAVIADFSGLLEKCCQGQEQEVCFAEEGQKLISKTRAALGV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
111PhosphorylationILEKYGHSDCCSQSE
HHHHHCCCCCCCCCC		28.1626091039
115PhosphorylationYGHSDCCSQSEEGRH
HCCCCCCCCCCCCCC		42.9726091039
117PhosphorylationHSDCCSQSEEGRHNC
CCCCCCCCCCCCCCC		22.7126091039
232PhosphorylationAVMKNFGTRTFQAIT
HHHHHCCCCEEEEEE		23.5424719451
234PhosphorylationMKNFGTRTFQAITVT
HHHCCCCEEEEEEEE		21.6720068231
239PhosphorylationTRTFQAITVTKLSQK
CCEEEEEEEEECCHH		25.7424719451
239O-linked_GlycosylationTRTFQAITVTKLSQK
CCEEEEEEEEECCHH		25.74OGP
241O-linked_GlycosylationTFQAITVTKLSQKFT
EEEEEEEEECCHHCC		20.02OGP
241PhosphorylationTFQAITVTKLSQKFT
EEEEEEEEECCHHCC		20.0220068231
248PhosphorylationTKLSQKFTKVNFTEI
EECCHHCCCCCHHHH		40.9146160229
251N-linked_GlycosylationSQKFTKVNFTEIQKL
CHHCCCCCHHHHHHH		39.417524678
251N-linked_GlycosylationSQKFTKVNFTEIQKL
CHHCCCCCHHHHHHH		39.417524678
255UbiquitinationTKVNFTEIQKLVLDV
CCCCHHHHHHHHHHH		3.8832015554
327PhosphorylationDEKPEGLSPNLNRFL
CCCCCCCCCCHHHHH		23.6926422651
344PhosphorylationRDFNQFSSGEKNIFL
CCHHHCCCCCCCEEH		52.8626091039
368PhosphorylationRHPQLAVSVILRVAK
HCHHHHHHHHHHHHH		9.6146160217
404PhosphorylationGEEELQKYIQESQAL
CHHHHHHHHHHHHHH		8.5526330541
408PhosphorylationLQKYIQESQALAKRS
HHHHHHHHHHHHHHH		12.3626330541
413UbiquitinationQESQALAKRSCGLFQ
HHHHHHHHHHCCHHH		45.7732015554
413AcetylationQESQALAKRSCGLFQ
HHHHHHHHHHCCHHH		45.77132723
415PhosphorylationSQALAKRSCGLFQKL
HHHHHHHHCCHHHHH		16.3046160223
444O-linked_GlycosylationKKAPQLTSSELMAIT
CCCCCCCHHHHHHHH		30.33OGP
444PhosphorylationKKAPQLTSSELMAIT
CCCCCCCHHHHHHHH		30.3326091039
445PhosphorylationKAPQLTSSELMAITR
CCCCCCHHHHHHHHH		29.5226091039
445O-linked_GlycosylationKAPQLTSSELMAITR
CCCCCCHHHHHHHHH		29.52OGP
457PhosphorylationITRKMAATAATCCQL
HHHHHHHHHHHHHHC		13.7929978859
460PhosphorylationKMAATAATCCQLSED
HHHHHHHHHHHCCCC		16.0229978859
465PhosphorylationAATCCQLSEDKLLAC
HHHHHHCCCCHHHHC		20.1928509920
576PhosphorylationEAVIADFSGLLEKCC
HHHHHHHHHHHHHHC		29.1322210691
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
111SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
115SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
117SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
344SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
444SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
445SPhosphorylationKinaseFAM20CQ8IXL6
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FETA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FETA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CCR5_HUMANCCR5physical
12176010
XIAP_HUMANXIAPphysical
16869888
PSB7_HUMANPSMB7physical
21988832
GBB1_HUMANGNB1physical
21988832
EHD4_HUMANEHD4physical
21988832
MED27_HUMANMED27physical
21988832
AP4S1_HUMANAP4S1physical
21988832
PHB2_HUMANPHB2physical
21988832
PIDD1_HUMANPIDD1physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615969Alpha-fetoprotein deficiency (AFPD)
615970Alpha-fetoprotein, hereditary persistence (HPAFP)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FETA_HUMAN

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Related Literatures of Post-Translational Modification

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