FBX16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX16_HUMAN
• UniProt AC: Q8IX29
• Protein Name: F-box only protein 16
• Gene Name: FBXO16
• Organism: Homo sapiens (Human).
• Sequence Length: 292
• Protein Description: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation..
• Protein Sequence: MMAFAPPKNTDGPKMQTKMSTWTPLNHQLLNDRVFEERRALLGKWFDKWTDSQRRRILTGLLERCSLSQQKFCCRKLQEKIPAEALDFTTKLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLAELDQLWMLKCLRFNWYINFSPTPFEQGIWKKHYIQMVKELHITKPKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHPTDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSRRNPFPLCP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MMAFAPPKNTDGPKM CCCCCCCCCCCCCCC	72.00	19413330
10	Phosphorylation	AFAPPKNTDGPKMQT CCCCCCCCCCCCCCC	48.75	19413330
170	Phosphorylation	LHITKPKTPPKDGFV HCCCCCCCCCCCCEE	54.04	27966365
197	Phosphorylation	EEKQSPLSAFRSSSS HHHCCCHHHHHCHHH	28.84	24719451
255	Phosphorylation	RRKRNQMTPDFSRQS HHHHHCCCCCHHHHC	15.22	26074081
259	Phosphorylation	NQMTPDFSRQSHDKK HCCCCCHHHHCHHHH	36.47	27794612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX16_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FBX16_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10, AND MASSSPECTROMETRY.
PubMed: 19413330