DAAF4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DAAF4_HUMAN
• UniProt AC: Q8WXU2
• Protein Name: Dynein assembly factor 4, axonemal {ECO:0000312|HGNC:HGNC:21493}
• Gene Name: DNAAF4 {ECO:0000312|HGNC:HGNC:21493}
• Organism: Homo sapiens (Human).
• Sequence Length: 420
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity..
• Protein Sequence: MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEERKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAACHLKLKNLHKAIEDSSKALELLMPPVTDNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPSNKIVQIDAEKIRNVIQGTELKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
102	Ubiquitination	MMQRIREKSILQAQE HHHHHHHHHHHHHHH		-
103	O-linked_Glycosylation	MQRIREKSILQAQER HHHHHHHHHHHHHHH		30620550
127	Acetylation	AAKREDQKYALSVMM HHCHHHHHHHHHHHH		24889123
128	Phosphorylation	AKREDQKYALSVMMK HCHHHHHHHHHHHHH		-
135	Methylation	YALSVMMKIEEEERK HHHHHHHHHCHHHHH		-
180	Acetylation	KKIQREEKLCQKEKQ HHHHHHHHHHHHHHH		7709797
198	Ubiquitination	ERKKIKYKSLTRNLA HHHHHHHHHHHHHHH		-
199	Phosphorylation	RKKIKYKSLTRNLAS HHHHHHHHHHHHHHH		-
206	Phosphorylation	SLTRNLASRNLAPKG HHHHHHHHCCCCCCC		-
216	Phosphorylation	LAPKGRNSENIFTEK CCCCCCCCCCCCCHH		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DAAF4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DAAF4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DAAF4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS71B_MOUSE	Hspa1b	physical	15189447
KDM1A_HUMAN	KDM1A	physical	23455924
NCK2_HUMAN	NCK2	physical	26186194
NCK2_HUMAN	NCK2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.