NRX3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRX3A_HUMAN
• UniProt AC: Q9Y4C0
• Protein Name: Neurexin-3
• Gene Name: NRXN3
• Organism: Homo sapiens (Human).
• Sequence Length: 1643
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling..
• Protein Sequence: MSSTLHSVFFTLKVSILLGSLLGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLDGVQAMPGFKGLILDLKYGNSEPRLLGSRGVQMDAEGPCGERPCENGGICFLLDGHPTCDCSTTGYGGKLCSEDVSQDPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	LPNQWARYLRWDAST CCHHHHHHHCCCCCC	7.90	29759185
47	Phosphorylation	YLRWDASTRSDLSFQ HHCCCCCCCCCEEEE	35.59	29759185
58	N-linked_Glycosylation	LSFQFKTNVSTGLLL EEEEEEECCCCCEEE	26.74	UniProtKB CARBOHYD
88	Dimethylation	VDGRVQLRFSMDCAE CCCEEEEEEECCHHH	12.42	-
88	Methylation	VDGRVQLRFSMDCAE CCCEEEEEEECCHHH	12.42	115390891
105	N-linked_Glycosylation	VLSNKQVNDSSWHFL EECCCCCCCCCCEEE	40.74	UniProtKB CARBOHYD
286	Phosphorylation	SSDEITLSFKTWQRN CCCEEEEEEEEEEEC	18.95	24719451
377	Phosphorylation	EDYTMLGSDDFFYVG HHEEEECCCCCEEEC	30.00	27542207
382	Phosphorylation	LGSDDFFYVGGSPST ECCCCCEEECCCCCC	9.74	27542207
386	Phosphorylation	DFFYVGGSPSTADLP CCEEECCCCCCCCCC	15.11	27542207
388	Phosphorylation	FYVGGSPSTADLPGS EEECCCCCCCCCCCC	37.61	27542207
389	Phosphorylation	YVGGSPSTADLPGSP EECCCCCCCCCCCCC	27.81	27542207
395	Phosphorylation	STADLPGSPVSNNFM CCCCCCCCCCCCCHH	21.86	27542207
398	Phosphorylation	DLPGSPVSNNFMGCL CCCCCCCCCCHHHHH	29.46	27542207
459	Phosphorylation	ETPEAYISLPKWNTK CCCHHEEECCCCCCC	26.41	24719451
518	Phosphorylation	ELLDGNLYLLLDMGS EECCCCEEEEEECCC	10.17	28787133
527	Phosphorylation	LLDMGSGTIKVKATQ EEECCCCEEEEEEEE	21.23	28787133
557	Phosphorylation	DGRSGTISVNSRRTP CCCCEEEEECCCCCC	18.32	-
560	Phosphorylation	SGTISVNSRRTPFTA CEEEEECCCCCCCCC	22.45	-
581	Phosphorylation	LDLEGDMYLGGLPEN EECCCCEEECCCCCC	13.61	23879269
620	Phosphorylation	DLFIDGRSKNIRQLA HHEECCCCHHHHHHH	35.27	21712546
636	Methylation	MQNAAGVKSSCSRMS HHHHHCCHHHHHHCC	35.42	-
636	"N6,N6-dimethyllysine"	MQNAAGVKSSCSRMS HHHHHCCHHHHHHCC	35.42	-
637	Phosphorylation	QNAAGVKSSCSRMSA HHHHCCHHHHHHCCH	33.88	-
638	Phosphorylation	NAAGVKSSCSRMSAK HHHCCHHHHHHCCHH	15.47	-
719	Phosphorylation	RFMSQRAYGLLVATT HHHCHHCCEEEEEEC	15.53	24719451
725	Phosphorylation	AYGLLVATTSRDSAD CCEEEEEECCCCCCC	20.16	24719451
726	Phosphorylation	YGLLVATTSRDSADT CEEEEEECCCCCCCE	16.42	27251275
757	N-linked_Glycosylation	DCIRINCNSSKGPET EEEEEECCCCCCCCE	44.84	UniProtKB CARBOHYD
787	Phosphorylation	RVVRRGKSLKLTVDD EEEECCCCEEEEECC	33.29	22115753
791	Phosphorylation	RGKSLKLTVDDDVAE CCCCEEEEECCCCCC	21.94	22115753
800	Phosphorylation	DDDVAEGTMVGDHTR CCCCCCCCCCCCCCE	10.53	22115753
806	Phosphorylation	GTMVGDHTRLEFHNI CCCCCCCCEEEEECC	41.51	22115753
815	Phosphorylation	LEFHNIETGIMTEKR EEEECCCCCCCCCCC	28.36	25627689
819	Phosphorylation	NIETGIMTEKRYISV CCCCCCCCCCCEEEE	36.11	25627689
993	Phosphorylation	LDLKGDLYMAGLAQG CCCCCCCHHHHHHHC	6.94	25072903
1002	Phosphorylation	AGLAQGMYSNLPKLV HHHHHCHHHCCCHHH	10.96	25072903
1003	Phosphorylation	GLAQGMYSNLPKLVA HHHHCHHHCCCHHHH	24.01	25072903
1011	Phosphorylation	NLPKLVASRDGFQGC CCCHHHHCCCCCCCE	24.35	-
1171	Phosphorylation	ISIKEERTPVNDGKY EEEECCCCCCCCCCE	34.56	24114839
1189	N-linked_Glycosylation	RFTRNGGNATLQVDN EEEECCCCEEEEECC	31.02	UniProtKB CARBOHYD
1257	N-linked_Glycosylation	NNPNIKINGSVRLVG CCCCCEECCEEEEEE	31.52	UniProtKB CARBOHYD
1292	Phosphorylation	TVMETTTTMATTTTR EEEEEECCEEEECCC	11.61	23403867
1295	Phosphorylation	ETTTTMATTTTRKNR EEECCEEEECCCCCC	17.53	23403867
1296	Phosphorylation	TTTTMATTTTRKNRS EECCEEEECCCCCCC	19.34	23403867
1301	N-linked_Glycosylation	ATTTTRKNRSTASIQ EEECCCCCCCCCEEC	39.58	UniProtKB CARBOHYD
1321	Phosphorylation	LVSSAECSSDDEDFV CHHCCCCCCCCCCCE	28.45	-
1322	Phosphorylation	VSSAECSSDDEDFVE HHCCCCCCCCCCCEE	61.82	-
1362	Phosphorylation	ATRAPSITLPPTFRP CCCCCCCCCCCCCHH	37.23	-
1372	Phosphorylation	PTFRPLLTIIETTKD CCCHHHEEEEECCCC	27.82	-
1535	Phosphorylation	LKSPLITSPMFRNVP CCCCCCCCCCCCCCC	13.84	-
1558	Phosphorylation	IRRVPGASEVIRESS CCCCCCCHHHHHCCC	38.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRX3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRX3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRX3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NLGN1_HUMAN	NLGN1	physical	8576240
NLGN2_HUMAN	NLGN2	physical	8576240
NLGN3_HUMAN	NLGN3	physical	8576240

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.