| UniProt ID | NLGN3_HUMAN | |
|---|---|---|
| UniProt AC | Q9NZ94 | |
| Protein Name | Neuroligin-3 | |
| Gene Name | NLGN3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 848 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein. Cell junction, synapse. Detected at both glutamatergic and GABAergic synapses.. |
|
| Protein Description | Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).. | |
| Protein Sequence | MWLRLGPPSLSLSPKPTVGRSLCLTLWFLSLALRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAQGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGAGAPELGAAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPHSHSTTRV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | RLGPPSLSLSPKPTV CCCCCCCCCCCCCCC | 31.01 | 24719451 | |
| 13 | Phosphorylation | GPPSLSLSPKPTVGR CCCCCCCCCCCCCCH | 27.74 | 21815630 | |
| 98 | N-linked_Glycosylation | PSWSGIRNATHFPPV CCCCCCCCCCCCCCC | 47.47 | UniProtKB CARBOHYD | |
| 269 | Phosphorylation | IQALRWVSENIAFFG HHHHHHHHHCCEECC | 20.26 | - | |
| 441 | Phosphorylation | SNFVDNLYGYPEGKD HHHHHHHHCCCCCHH | 22.37 | - | |
| 443 | Phosphorylation | FVDNLYGYPEGKDTL HHHHHHCCCCCHHHH | 5.64 | - | |
| 502 | Phosphorylation | ARYGSPTYFYAFYHH HHHCCCHHHHHHHHH | 9.66 | 22210691 | |
| 504 | Phosphorylation | YGSPTYFYAFYHHCQ HCCCHHHHHHHHHHH | 5.84 | 22210691 | |
| 507 | Phosphorylation | PTYFYAFYHHCQSLM CHHHHHHHHHHHHHH | 5.18 | 22210691 | |
| 512 | Phosphorylation | AFYHHCQSLMKPAWS HHHHHHHHHHCCHHH | 35.51 | 22210691 | |
| 545 | N-linked_Glycosylation | PTDLFPCNFSKNDVM CCCCCCCCCCCCHHH | 44.45 | UniProtKB CARBOHYD | |
| 594 | Phosphorylation | RFEEVAWSKYNPRDQ CHHHCHHHHCCCCCC | 18.61 | 22210691 | |
| 745 | Phosphorylation | QEPLRQPSPQRGAGA CCCCCCCCCCCCCCC | 25.90 | 24043423 | |
| 792 | Phosphorylation | RLTALPDYTLTLRRS EEEECCCCEEEECCC | 11.17 | 26657352 | |
| 793 | Phosphorylation | LTALPDYTLTLRRSP EEECCCCEEEECCCC | 22.20 | 26657352 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NLGN3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NLGN3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NLGN3_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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