dbPTM

CP11A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CP11A_HUMAN
UniProt AC	P05108
Protein Name	Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name	CYP11A1
Organism	Homo sapiens (Human).
Sequence Length	521
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein . Localizes to the matrix side of the mitochondrion inner membrane.
Protein Description	Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones..
Protein Sequence	MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	KGCQTFLSAPREGLG ECHHHHHCCCCCCCC	31.84	24719451
113	Phosphorylation	DVALLFKSEGPNPER HHEEEEECCCCCHHH	40.21	-
164	Phosphorylation	EVMAPEATKNFLPLL HHCCHHHHHCHHHHH	25.51	-
275	Phosphorylation	AAWDVIFSKADIYTQ HHHHHHHHHHHEHHH	18.79	24719451
473	Phosphorylation	RIAELEMTIFLINML HHHHHHHHHHHHHHH	10.13	27535140

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CP11A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CP11A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CP11A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ADX_HUMAN	FDX1	physical	1429635

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CP11A_HUMAN

Related Literatures of Post-Translational Modification