PLCB4_HUMAN - dbPTM
PLCB4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLCB4_HUMAN
UniProt AC Q15147
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Gene Name PLCB4
Organism Homo sapiens (Human).
Sequence Length 1175
Subcellular Localization
Protein Description The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction..
Protein Sequence MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQLEHLEFLEKQNEQAKEMQQMVKLEAEMDRRPATVV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAKPYEFNW
------CCCCCCCCC		32.60-
63PhosphorylationEGQVLECSLINSIRS
CCCEEEEEECHHHHC		23.94-
67PhosphorylationLECSLINSIRSGAIP
EEEEECHHHHCCCCC		16.63-
78UbiquitinationGAIPKDPKILAALEA
CCCCCCHHHHHHHHH		61.5629967540
106UbiquitinationCVCSGTDLVNISFTY
EEEECCCEEEEEEEE		2.9723503661
113 (in isoform 2)Ubiquitination-6.38-
145PhosphorylationANNVSPMTCLKKHWM
CCCCCHHHHHHHHHH		20.3329759185
153UbiquitinationCLKKHWMKLAFMTNT
HHHHHHHHEEEEECC		31.3223503661
158PhosphorylationWMKLAFMTNTNGKIP
HHHEEEEECCCCCEE		32.2226074081
160PhosphorylationKLAFMTNTNGKIPVR
HEEEEECCCCCEEEE		35.8622210691
168PhosphorylationNGKIPVRSITRTFAS
CCCEEEEEEEEEECC		28.6626074081
170PhosphorylationKIPVRSITRTFASGK
CEEEEEEEEEECCCC		25.5526074081
172PhosphorylationPVRSITRTFASGKTE
EEEEEEEEECCCCHH		18.2026074081
175PhosphorylationSITRTFASGKTEKVI
EEEEEECCCCHHHHH		36.3126074081
178PhosphorylationRTFASGKTEKVIFQA
EEECCCCHHHHHHHH		44.5626074081
187UbiquitinationKVIFQALKELGLPSG
HHHHHHHHHCCCCCC		54.6429967540
193PhosphorylationLKELGLPSGKNDEIE
HHHCCCCCCCCCCCC		68.4024719451
195UbiquitinationELGLPSGKNDEIEPT
HCCCCCCCCCCCCCC		66.6129967540
208UbiquitinationPTAFSYEKFYELTQK
CCCCCHHHHHHHHHH		45.0429967540
213UbiquitinationYEKFYELTQKICPRT
HHHHHHHHHHHCCCC		18.8423503661
215UbiquitinationKFYELTQKICPRTDI
HHHHHHHHHCCCCCH		40.8329967540
227UbiquitinationTDIEDLFKKINGDKT
CCHHHHHHHHCCCCC		61.1029967540
266UbiquitinationLFPFYDAKRAMQIIE
CHHHHCHHHHHHHHH		37.48-
266UbiquitinationLFPFYDAKRAMQIIE
CHHHHCHHHHHHHHH		37.4833845483
275PhosphorylationAMQIIEMYEPDEDLK
HHHHHHHCCCCHHHH		16.1230622161
284UbiquitinationPDEDLKKKGLISSDG
CCHHHHHCCCCCCCC		58.3133845483
298PhosphorylationGFCRYLMSDENAPVF
CCHHHHCCCCCCCCC		38.9024719451
415PhosphorylationFENHCSKYQQYKMSK
ECCCHHHHHHHHHHH		5.6430622161
418PhosphorylationHCSKYQQYKMSKYCE
CHHHHHHHHHHHHHH		7.9830622161
421PhosphorylationKYQQYKMSKYCEDLF
HHHHHHHHHHHHHHH		19.1330622161
472UbiquitinationLKPEVEKKQLEALRS
CCHHHHHHHHHHHHH		46.7633845483
503PhosphorylationDNEEEIESADQEEEA
CCHHHHHCCHHHHHH		42.6927362937
521PhosphorylationFKFGNELSADDLGHK
CCCCCCCCHHHHCCH		24.3927732954
521 (in isoform 4)Phosphorylation-24.3924719451
528UbiquitinationSADDLGHKEAVANSV
CHHHHCCHHHHHHHH		45.6429967540
541PhosphorylationSVKKGLVTVEDEQAW
HHHCCCEEECCHHHH		24.1828851738
551PhosphorylationDEQAWMASYKYVGAT
CHHHHHHHCEEEECC		13.1728851738
620PhosphorylationNYNKRQMSRIYPKGG
ECCHHHHCCCCCCCC		13.7425599653
623PhosphorylationKRQMSRIYPKGGRVD
HHHHCCCCCCCCCCC		9.5917081983
720PhosphorylationLSDKKIGTYVEVDMY
CCCCCCEEEEEEECC		28.0625907765
721PhosphorylationSDKKIGTYVEVDMYG
CCCCCEEEEEEECCC		6.8725907765
727PhosphorylationTYVEVDMYGLPTDTI
EEEEEECCCCCHHHH		15.8525907765
731PhosphorylationVDMYGLPTDTIRKEF
EECCCCCHHHHHHHH		51.3125907765
733PhosphorylationMYGLPTDTIRKEFRT
CCCCCHHHHHHHHHH		25.7625907765
733 (in isoform 2)Phosphorylation-25.7621406692
736 (in isoform 2)Phosphorylation-58.3021406692
737 (in isoform 2)Phosphorylation-30.4321406692
754UbiquitinationGLNPVYNEESFVFRK
CCCCCCCCCCCCEEE		37.0123503661
766UbiquitinationFRKVILPDLAVLRIA
EEEECCCCCEEEEEE		43.7623503661
800PhosphorylationQAGYRHISLRNEGNK
CCCCEEEEEECCCCC		18.3624719451
800 (in isoform 4)Phosphorylation-18.3624719451
839UbiquitinationVDALSDPKKFLSITE
HHHHCCHHHHHHHHH		62.2329967540
843PhosphorylationSDPKKFLSITEKRAD
CCHHHHHHHHHHHHH		30.5128857561
843 (in isoform 4)Phosphorylation-30.5124719451
851UbiquitinationITEKRADQMRAMGIE
HHHHHHHHHHHCCCC		23.4429967540
867PhosphorylationSDIADVPSDTSKNDK
HHCCCCCCCCCCCCC		54.0619276368
869 (in isoform 2)Ubiquitination-46.0321906983
870UbiquitinationADVPSDTSKNDKKGK
CCCCCCCCCCCCCCC		34.1621906983
874UbiquitinationSDTSKNDKKGKANTA
CCCCCCCCCCCCCCC		73.2023503661
886PhosphorylationNTAKANVTPQSSSEL
CCCCCCCCCCCCCCC		18.5421955146
886 (in isoform 4)Phosphorylation-18.5424719451
889PhosphorylationKANVTPQSSSELRPT
CCCCCCCCCCCCCCC		36.7130278072
889 (in isoform 4)Phosphorylation-36.7124719451
890PhosphorylationANVTPQSSSELRPTT
CCCCCCCCCCCCCCC		23.6830278072
890 (in isoform 4)Phosphorylation-23.6827251275
891PhosphorylationNVTPQSSSELRPTTT
CCCCCCCCCCCCCCH		45.9922496350
896PhosphorylationSSSELRPTTTAALAS
CCCCCCCCCHHHHHH		30.2826657352
896 (in isoform 4)Phosphorylation-30.2824719451
897PhosphorylationSSELRPTTTAALASG
CCCCCCCCHHHHHHC		19.6829978859
897 (in isoform 4)Phosphorylation-19.6824719451
898PhosphorylationSELRPTTTAALASGV
CCCCCCCHHHHHHCC		16.6526657352
903PhosphorylationTTTAALASGVEAKKG
CCHHHHHHCCHHCCC		44.1929978859
921UbiquitinationIPQVRIEDLKQMKAY
CCCCCHHHHHHHHHH		57.7123503661
923UbiquitinationQVRIEDLKQMKAYLK
CCCHHHHHHHHHHHH		61.75-
926UbiquitinationIEDLKQMKAYLKHLK
HHHHHHHHHHHHHHH		31.24-
934AcetylationAYLKHLKKQQKELNS
HHHHHHHHHHHHHHH		65.417221463
937AcetylationKHLKKQQKELNSLKK
HHHHHHHHHHHHHHH		62.777221473
943AcetylationQKELNSLKKKHAKEH
HHHHHHHHHHHHHHH		60.6469171
944AcetylationKELNSLKKKHAKEHS
HHHHHHHHHHHHHHH		55.907221483
945AcetylationELNSLKKKHAKEHST
HHHHHHHHHHHHHHH		47.4069175
955UbiquitinationKEHSTMQKLHCTQVD
HHHHHHHHHHHHHHH		29.4029967540
967UbiquitinationQVDKIVAQYDKEKST
HHHHHHHHHHHCCCH		35.7429967540
969UbiquitinationDKIVAQYDKEKSTHE
HHHHHHHHHCCCHHH		40.3223503661
981UbiquitinationTHEKILEKAMKKKGG
HHHHHHHHHHHHCCC		50.7823503661
986AcetylationLEKAMKKKGGSNCLE
HHHHHHHCCCCCCCC		64.097965455
995AcetylationGSNCLEMKKETEIKI
CCCCCCCHHHHEEEE		37.777704283
996AcetylationSNCLEMKKETEIKIQ
CCCCCCHHHHEEEEE		69.437672333
998PhosphorylationCLEMKKETEIKIQTL
CCCCHHHHEEEEEEC		52.47-
1004PhosphorylationETEIKIQTLTSDHKS
HHEEEEEECCCCCHH		35.16-
1010UbiquitinationQTLTSDHKSKVKEIV
EECCCCCHHHHHHHH		57.8933845483
1014UbiquitinationSDHKSKVKEIVAQHT
CCCHHHHHHHHHHHH		45.5233845483
1021PhosphorylationKEIVAQHTKEWSEMI
HHHHHHHHHHHHHHH		20.69-
1022UbiquitinationEIVAQHTKEWSEMIN
HHHHHHHHHHHHHHH		55.8721906983
1022 (in isoform 1)Ubiquitination-55.8721906983
1026UbiquitinationQHTKEWSEMINTHSA
HHHHHHHHHHHCCCH		45.1933845483
1034UbiquitinationMINTHSAEEQEIRDL
HHHCCCHHHHHHHHH		64.33-
1034UbiquitinationMINTHSAEEQEIRDL
HHHCCCHHHHHHHHH		64.3332015554
1052UbiquitinationQQCELLKKLLINAHE
HHHHHHHHHHHHHHH		48.7929967540
1064UbiquitinationAHEQQTQQLKLSHDR
HHHHHHHHHHHHCCH		43.9129967540
1138UbiquitinationKEMDQLKKVQLEHLE
HHHHHHHHHHHHHHH		43.7529967540
1149UbiquitinationEHLEFLEKQNEQAKE
HHHHHHHHHHHHHHH		61.6529967540
1150UbiquitinationHLEFLEKQNEQAKEM
HHHHHHHHHHHHHHH		49.6829967540
1156UbiquitinationKQNEQAKEMQQMVKL
HHHHHHHHHHHHHHH		45.2829967540
1173PhosphorylationEMDRRPATVV-----
HHHCCCCCCC-----		25.2029691806
1177 (in isoform 4)Phosphorylation-27732954
1183 (in isoform 4)Phosphorylation-27251275
1184 (in isoform 4)Phosphorylation-27251275
1186 (in isoform 4)Phosphorylation-26471730
1187 (in isoform 4)Phosphorylation-24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLCB4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLCB4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLCB4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
REL_HUMANRELphysical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614669Auriculocondylar syndrome 2 (ARCND2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLCB4_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-890, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-620 AND TYR-623, ANDMASS SPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory