NADC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NADC_HUMAN
• UniProt AC: Q15274
• Protein Name: Nicotinate-nucleotide pyrophosphorylase [carboxylating]
• Gene Name: QPRT
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Protein Description: Involved in the catabolism of quinolinic acid (QA)..
• Protein Sequence: MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	S-nitrosocysteine	EVRGPAHCLLLGERV EECCCHHHEEECHHH	2.88	-
96	S-nitrosylation	EVRGPAHCLLLGERV EECCCHHHEEECHHH	2.88	19483679
139	Ubiquitination	GHVAGTRKTTPGFRL CCCCCCCCCCCCCEE	57.50	-
149	Ubiquitination	PGFRLVEKYGLLVGG CCCEEEEHHCEEEEC	36.82	-
150	Phosphorylation	GFRLVEKYGLLVGGA CCEEEEHHCEEEECC	10.25	21406692
159	Phosphorylation	LLVGGAASHRYDLGG EEEECCCCCCEECCC	14.15	21406692
161	Dimethylation	VGGAASHRYDLGGLV EECCCCCCEECCCEE	24.94	-
161	Methylation	VGGAASHRYDLGGLV EECCCCCCEECCCEE	24.94	115372775
162	Phosphorylation	GGAASHRYDLGGLVM ECCCCCCEECCCEEE	15.31	-
171	Ubiquitination	LGGLVMVKDNHVVAA CCCEEEEECCEEEEE	34.42	-
171	Acetylation	LGGLVMVKDNHVVAA CCCEEEEECCEEEEE	34.42	26051181
183	Acetylation	VAAGGVEKAVRAARQ EEECHHHHHHHHHHH	50.18	11789889
183	Ubiquitination	VAAGGVEKAVRAARQ EEECHHHHHHHHHHH	50.18	-
225	Ubiquitination	LVLLDNFKPEELHPT EEEEECCCHHHCCCC	58.75	-
288	Ubiquitination	FSLKLFAKEVAPVPK HHHHHHHHHCCCCCC	45.44	-
295	Ubiquitination	KEVAPVPKIH----- HHCCCCCCCC-----	54.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NADC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NADC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NADC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
SUFU_HUMAN	SUFU	physical	16189514
NT2NL_HUMAN	NOTCH2NL	physical	24722188
NADC_HUMAN	QPRT	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
PRC2C_HUMAN	PRRC2C	physical	26186194
SMRD2_HUMAN	SMARCD2	physical	26186194
SEH1_HUMAN	SEH1L	physical	26186194
RAVR2_HUMAN	RAVER2	physical	26186194
SRCAP_HUMAN	SRCAP	physical	26186194
BCOR_HUMAN	BCOR	physical	26186194
TGO1_HUMAN	MIA3	physical	26186194
SF3A1_HUMAN	SF3A1	physical	26186194
PER1_HUMAN	PER1	physical	26186194
TIF1A_HUMAN	TRIM24	physical	26186194
TRI33_HUMAN	TRIM33	physical	26186194
IF4G3_HUMAN	EIF4G3	physical	26186194
ZMYM6_HUMAN	ZMYM6	physical	26186194
SFR15_HUMAN	SCAF4	physical	26186194
P3C2A_HUMAN	PIK3C2A	physical	26186194
DMAP1_HUMAN	DMAP1	physical	26186194
CRY2_HUMAN	CRY2	physical	26186194
CRY1_HUMAN	CRY1	physical	26186194
ARP6_HUMAN	ACTR6	physical	26186194
SF3A3_HUMAN	SF3A3	physical	26186194
ARI1B_HUMAN	ARID1B	physical	26186194
CCAR1_HUMAN	CCAR1	physical	26186194
NCOR1_HUMAN	NCOR1	physical	26186194
SF3A2_HUMAN	SF3A2	physical	26186194
TBL1R_HUMAN	TBL1XR1	physical	26186194
IF4G2_HUMAN	EIF4G2	physical	26186194
VPS72_HUMAN	VPS72	physical	26186194
TLE1_HUMAN	TLE1	physical	26186194
TLE3_HUMAN	TLE3	physical	26186194
TLE4_HUMAN	TLE4	physical	26186194
PATL1_HUMAN	PATL1	physical	26186194
HDAC3_HUMAN	HDAC3	physical	26186194
CIKS_HUMAN	TRAF3IP2	physical	26186194
ADNP_HUMAN	ADNP	physical	26186194
SATB2_HUMAN	SATB2	physical	26186194
SATB1_HUMAN	SATB1	physical	26186194
I2BP1_HUMAN	IRF2BP1	physical	26186194
RAVR2_HUMAN	RAVER2	physical	28514442
SATB2_HUMAN	SATB2	physical	28514442
SATB1_HUMAN	SATB1	physical	28514442
CIKS_HUMAN	TRAF3IP2	physical	28514442
TRI33_HUMAN	TRIM33	physical	28514442
I2BP1_HUMAN	IRF2BP1	physical	28514442
PATL1_HUMAN	PATL1	physical	28514442
CRY2_HUMAN	CRY2	physical	28514442
PER1_HUMAN	PER1	physical	28514442
SF3A2_HUMAN	SF3A2	physical	28514442
TIF1A_HUMAN	TRIM24	physical	28514442
IF4G2_HUMAN	EIF4G2	physical	28514442
P3C2A_HUMAN	PIK3C2A	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442
SFR15_HUMAN	SCAF4	physical	28514442
VPS72_HUMAN	VPS72	physical	28514442
ARP6_HUMAN	ACTR6	physical	28514442
PRC2C_HUMAN	PRRC2C	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
BCOR_HUMAN	BCOR	physical	28514442
TBL1R_HUMAN	TBL1XR1	physical	28514442
SRCAP_HUMAN	SRCAP	physical	28514442
CRY1_HUMAN	CRY1	physical	28514442
IF4G3_HUMAN	EIF4G3	physical	28514442
SMRD2_HUMAN	SMARCD2	physical	28514442
P66B_HUMAN	GATAD2B	physical	28514442
ARI1B_HUMAN	ARID1B	physical	28514442
ADNP_HUMAN	ADNP	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00627: Niacin