dbPTM

DPEP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DPEP2_HUMAN
UniProt AC	Q9H4A9
Protein Name	Dipeptidase 2
Gene Name	DPEP2
Organism	Homo sapiens (Human).
Sequence Length	486
Subcellular Localization	Membrane Lipid-anchor, GPI-anchor.
Protein Description	Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4)..
Protein Sequence	MQPSGLEGPGTFGRWPLLSLLLLLLLLQPVTCAYTTPGPPRALTTLGAPRAHTMPGTYAPSTTLSSPSTQGLQEQARALMRDFPLVDGHNDLPLVLRQVYQKGLQDVNLRNFSYGQTSLDRLRDGLVGAQFWSAYVPCQTQDRDALRLTLEQIDLIRRMCASYSELELVTSAKALNDTQKLACLIGVEGGHSLDNSLSILRTFYMLGVRYLTLTHTCNTPWAESSAKGVHSFYNNISGLTDFGEKVVAEMNRLGMMVDLSHVSDAVARRALEVSQAPVIFSHSAARGVCNSARNVPDDILQLLKKNGGVVMVSLSMGVIQCNPSANVSTVADHFDHIKAVIGSKFIGIGGDYDGAGKFPQGLEDVSTYPVLIEELLSRGWSEEELQGVLRGNLLRVFRQVEKVQEENKWQSPLEDKFPDEQLSSSCHSDLSRLRQRQSLTSGQELTEIPIHWTAKLPAKWSVSESSPHMAPVLAVVATFPVLILWL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	SGLEGPGTFGRWPLL CCCCCCCCCCHHHHH	26.50	22798277
36	Phosphorylation	PVTCAYTTPGPPRAL HHCCCCCCCCCCCHH	17.36	24719451
53	Phosphorylation	LGAPRAHTMPGTYAP CCCCCCCCCCCCCCC	24.87	-
69	O-linked_Glycosylation	TTLSSPSTQGLQEQA CCCCCCCCHHHHHHH	30.00	OGP
100	Phosphorylation	PLVLRQVYQKGLQDV HHHHHHHHHHCCCCC	9.00	27067055
111	N-linked_Glycosylation	LQDVNLRNFSYGQTS CCCCCCCCCCCCCCH	33.12	16335952
162	Phosphorylation	LIRRMCASYSELELV HHHHHHCCCHHHHHH	25.02	30631047
170	Phosphorylation	YSELELVTSAKALND CHHHHHHHCHHHCCC	35.27	30631047
171	Phosphorylation	SELELVTSAKALNDT HHHHHHHCHHHCCCH	21.94	30631047
176	N-linked_Glycosylation	VTSAKALNDTQKLAC HHCHHHCCCHHHEEH	55.96	UniProtKB CARBOHYD
235	N-linked_Glycosylation	GVHSFYNNISGLTDF CHHHHHHCCCCCCHH	20.58	16335952
377	Phosphorylation	VLIEELLSRGWSEEE HHHHHHHHCCCCHHH	41.18	24719451
463	GPI-anchor	LPAKWSVSESSPHMA CCCCCCCCCCCCCHH	26.67	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DPEP2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DPEP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DPEP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMD_HUMAN	PAM	physical	26186194
METL9_HUMAN	METTL9	physical	26186194
ITAV_HUMAN	ITGAV	physical	26186194
GALNS_HUMAN	GALNS	physical	26186194
ERD23_HUMAN	KDELR3	physical	26186194
OS9_HUMAN	OS9	physical	26186194
CHPF2_HUMAN	CHPF2	physical	26186194
GFPT2_HUMAN	GFPT2	physical	26186194
FUT11_HUMAN	FUT11	physical	26186194
YIF1A_HUMAN	YIF1A	physical	26186194
PGLT1_HUMAN	POGLUT1	physical	26186194
CHSTC_HUMAN	CHST12	physical	26186194
WRB_HUMAN	WRB	physical	26186194
EMIL3_HUMAN	EMILIN3	physical	26186194
PLTP_HUMAN	PLTP	physical	26186194
LRFN3_HUMAN	LRFN3	physical	26186194
HYAL2_HUMAN	HYAL2	physical	26186194
HYAL2_HUMAN	HYAL2	physical	28514442
LRFN3_HUMAN	LRFN3	physical	28514442
PGLT1_HUMAN	POGLUT1	physical	28514442
FUT11_HUMAN	FUT11	physical	28514442
GALNS_HUMAN	GALNS	physical	28514442
PLTP_HUMAN	PLTP	physical	28514442
ERD23_HUMAN	KDELR3	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
ARSK_HUMAN	ARSK	physical	28514442
TAZ_HUMAN	TAZ	physical	28514442
METL9_HUMAN	METTL9	physical	28514442
ARSA_HUMAN	ARSA	physical	28514442
OS9_HUMAN	OS9	physical	28514442
CHPF2_HUMAN	CHPF2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DPEP2_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-111 AND ASN-235, AND MASSSPECTROMETRY.	16335952 [Abstract]