HID1_HUMAN - dbPTM
HID1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HID1_HUMAN
UniProt AC Q8IV36
Protein Name Protein HID1
Gene Name HID1
Organism Homo sapiens (Human).
Sequence Length 788
Subcellular Localization Cytoplasm . Golgi apparatus membrane
Lipid-anchor . Shuttles between the cytosol and the Golgi apparatus.
Protein Description May play an important role in the development of cancers in a broad range of tissues..
Protein Sequence MGSTDSKLNFRKAVIQLTTKTQPVEATDDAFWDQFWADTATSVQDVFALVPAAEIRAVREESPSNLATLCYKAVEKLVQGAESGCHSEKEKQIVLNCSRLLTRVLPYIFEDPDWRGFFWSTVPGAGRGGQGEEDDEHARPLAESLLLAIADLLFCPDFTVQSHRRSTVDSAEDVHSLDSCEYIWEAGVGFAHSPQPNYIHDMNRMELLKLLLTCFSEAMYLPPAPESGSTNPWVQFFCSTENRHALPLFTSLLNTVCAYDPVGYGIPYNHLLFSDYREPLVEEAAQVLIVTLDHDSASSASPTVDGTTTGTAMDDADPPGPENLFVNYLSRIHREEDFQFILKGIARLLSNPLLQTYLPNSTKKIQFHQELLVLFWKLCDFNKKFLFFVLKSSDVLDILVPILFFLNDARADQSRVGLMHIGVFILLLLSGERNFGVRLNKPYSIRVPMDIPVFTGTHADLLIVVFHKIITSGHQRLQPLFDCLLTIVVNVSPYLKSLSMVTANKLLHLLEAFSTTWFLFSAAQNHHLVFFLLEVFNNIIQYQFDGNSNLVYAIIRKRSIFHQLANLPTDPPTIHKALQRRRRTPEPLSRTGSQEGTSMEGSRPAAPAEPGTLKTSLVATPGIDKLTEKSQVSEDGTLRSLEPEPQQSLEDGSPAKGEPSQAWREQRRPSTSSASGQWSPTPEWVLSWKSKLPLQTIMRLLQVLVPQVEKICIDKGLTDESEILRFLQHGTLVGLLPVPHPILIRKYQANSGTAMWFRTYMWGVIYLRNVDPPVWYDTDVKLFEIQRV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Myristoylation------MGSTDSKLN
------CCCCHHHHH		38.9721337012
2N-myristoyl glycine------MGSTDSKLN
------CCCCHHHHH		38.97-
4O-linked_Glycosylation----MGSTDSKLNFR
----CCCCHHHHHHH		38.2630379171
4Phosphorylation----MGSTDSKLNFR
----CCCCHHHHHHH		38.2624719451
6O-linked_Glycosylation--MGSTDSKLNFRKA
--CCCCHHHHHHHHH		38.8530379171
6Phosphorylation--MGSTDSKLNFRKA
--CCCCHHHHHHHHH		38.8524719451
68PhosphorylationESPSNLATLCYKAVE
CCCCHHHHHHHHHHH		22.1128060719
83PhosphorylationKLVQGAESGCHSEKE
HHHHHHHCCCCCHHH		46.3022468782
87O-linked_GlycosylationGAESGCHSEKEKQIV
HHHCCCCCHHHHHHH		55.2130379171
121PhosphorylationWRGFFWSTVPGAGRG
CCCCEEECCCCCCCC		22.70-
135 (in isoform 3)Ubiquitination-53.5121906983
144PhosphorylationHARPLAESLLLAIAD
CHHHHHHHHHHHHHH		20.79-
170PhosphorylationHRRSTVDSAEDVHSL
CCCCCCCCHHHHHCC		29.2628348404
362 (in isoform 2)Ubiquitination-42.8921906983
363 (in isoform 1)Ubiquitination-47.9321906983
363UbiquitinationTYLPNSTKKIQFHQE
HHCCCCCCCEEHHHH		47.932190698
430PhosphorylationVFILLLLSGERNFGV
HHHHHHHHCCCCCCC		38.2820068231
444PhosphorylationVRLNKPYSIRVPMDI
CCCCCCEEEEECCCC		16.6724719451
559PhosphorylationYAIIRKRSIFHQLAN
EEHHHHCCHHHHHHC		32.4226657352
584PhosphorylationALQRRRRTPEPLSRT
HHHHHCCCCCCCCCC		30.1423312004
589PhosphorylationRRTPEPLSRTGSQEG
CCCCCCCCCCCCCCC		38.2123312004
591PhosphorylationTPEPLSRTGSQEGTS
CCCCCCCCCCCCCCC		37.5030278072
593PhosphorylationEPLSRTGSQEGTSME
CCCCCCCCCCCCCCC		25.1723401153
597PhosphorylationRTGSQEGTSMEGSRP
CCCCCCCCCCCCCCC		24.9326657352
598PhosphorylationTGSQEGTSMEGSRPA
CCCCCCCCCCCCCCC		26.2023403867
602PhosphorylationEGTSMEGSRPAAPAE
CCCCCCCCCCCCCCC		23.0623403867
612PhosphorylationAAPAEPGTLKTSLVA
CCCCCCCCEEEEEEE		35.4823403867
616PhosphorylationEPGTLKTSLVATPGI
CCCCEEEEEEECCCH		21.1827251275
620PhosphorylationLKTSLVATPGIDKLT
EEEEEEECCCHHHHC		17.9927251275
629UbiquitinationGIDKLTEKSQVSEDG
CHHHHCCCCCCCCCC		40.7433845483
633PhosphorylationLTEKSQVSEDGTLRS
HCCCCCCCCCCCCCC		23.4928348404
637PhosphorylationSQVSEDGTLRSLEPE
CCCCCCCCCCCCCCC		31.1826657352
640PhosphorylationSEDGTLRSLEPEPQQ
CCCCCCCCCCCCCCC		39.9525849741
648PhosphorylationLEPEPQQSLEDGSPA
CCCCCCCCCCCCCCC		28.6026657352
653PhosphorylationQQSLEDGSPAKGEPS
CCCCCCCCCCCCCCC		33.7219664994
660PhosphorylationSPAKGEPSQAWREQR
CCCCCCCCHHHHHHC		28.3830243723
670PhosphorylationWREQRRPSTSSASGQ
HHHHCCCCCCCCCCC		38.8327273156
671PhosphorylationREQRRPSTSSASGQW
HHHCCCCCCCCCCCC		29.4127273156
672PhosphorylationEQRRPSTSSASGQWS
HHCCCCCCCCCCCCC		28.3923898821
673PhosphorylationQRRPSTSSASGQWSP
HCCCCCCCCCCCCCC		26.9227273156
675PhosphorylationRPSTSSASGQWSPTP
CCCCCCCCCCCCCCC		33.2021082442
679PhosphorylationSSASGQWSPTPEWVL
CCCCCCCCCCCHHHH		15.8230087585
681PhosphorylationASGQWSPTPEWVLSW
CCCCCCCCCHHHHHC		28.4628102081
696PhosphorylationKSKLPLQTIMRLLQV
CCCCCHHHHHHHHHH		25.1523403867
747PhosphorylationHPILIRKYQANSGTA
CCEEEEEEECCCCCC		11.74-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HID1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HID1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HID1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHIP2_HUMANINPPL1physical
20368287
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HID1_HUMAN

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Related Literatures of Post-Translational Modification
Myristoylation
ReferencePubMed
"HID-1 is a peripheral membrane protein primarily associated with themedial- and trans- Golgi apparatus.";
Wang L., Zhan Y., Song E., Yu Y., Jiu Y., Du W., Lu J., Liu P., Xu P.,Xu T.;
Protein Cell 2:74-85(2011).
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MYRISTOYLATION AT GLY-2.

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