TPRA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPRA1_HUMAN
• UniProt AC: Q86W33
• Protein Name: Transmembrane protein adipocyte-associated 1
• Gene Name: TPRA1
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Sequence: MDTLEEVTWANGSTALPPPLAPNISVPHRCLLLLYEDIGTSRVRYWDLLLLIPNVLFLIFLLWKLPSARAKIRITSSPIFITFYILVFVVALVGIARAVVSMTVSTSNAATVADKILWEITRFFLLAIELSVIILGLAFGHLESKSSIKRVLAITTVLSLAYSVTQGTLEILYPDAHLSAEDFNIYGHGGRQFWLVSSCFFFLVYSLVVILPKTPLKERISLPSRRSFYVYAGILALLNLLQGLGSVLLCFDIIEGLCCVDATTFLYFSFFAPLIYVAFLRGFFGSEPKILFSYKCQVDETEEPDVHLPQPYAVARREGLEAAGAAGASAASYSSTQFDSAGGVAYLDDIASMPCHTGSINSTDSERWKAINA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDTLEEVTWA -----CCCHHHCCCC	34.47	-
11	N-linked_Glycosylation	LEEVTWANGSTALPP HHHCCCCCCCCCCCC	36.19	UniProtKB CARBOHYD
14	Phosphorylation	VTWANGSTALPPPLA CCCCCCCCCCCCCCC	33.34	-
23	N-linked_Glycosylation	LPPPLAPNISVPHRC CCCCCCCCCCCCHHH	33.29	UniProtKB CARBOHYD
252	Ubiquitination	GSVLLCFDIIEGLCC CHHHHHHHHHHCCCC	39.70	21890473
258	Ubiquitination	FDIIEGLCCVDATTF HHHHHCCCCCCHHHH	2.90	21963094
289	Ubiquitination	GFFGSEPKILFSYKC HHHCCCCEEEEEEEE	48.25	22817900
289 (in isoform 1)	Ubiquitination	-	48.25	21890473
293	Phosphorylation	SEPKILFSYKCQVDE CCCEEEEEEEECCCC	21.90	23312004
294	Phosphorylation	EPKILFSYKCQVDET CCEEEEEEEECCCCC	14.40	23312004
295	Ubiquitination	PKILFSYKCQVDETE CEEEEEEEECCCCCC	19.59	21963094
301	Phosphorylation	YKCQVDETEEPDVHL EEECCCCCCCCCCCC	40.98	21945579
312	Phosphorylation	DVHLPQPYAVARREG CCCCCCCHHHHHHHH	14.41	21945579
361	N-linked_Glycosylation	PCHTGSINSTDSERW CCCCCCCCCCCHHHH	40.32	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPRA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPRA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPRA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SC6A8_HUMAN	SLC6A8	physical	28514442
MFSD8_HUMAN	MFSD8	physical	28514442
CP2S1_HUMAN	CYP2S1	physical	28514442
ZNT5_HUMAN	SLC30A5	physical	28514442
BMR1B_HUMAN	BMPR1B	physical	28514442
TM143_HUMAN	TMEM143	physical	28514442
ZNT6_HUMAN	SLC30A6	physical	28514442
SNX13_HUMAN	SNX13	physical	28514442
CSCL2_HUMAN	TMEM63B	physical	28514442
DOLK_HUMAN	DOLK	physical	28514442
SC5D_HUMAN	SC5D	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
GHITM_HUMAN	GHITM	physical	28514442
CSCL1_HUMAN	TMEM63A	physical	28514442
ATG9A_HUMAN	ATG9A	physical	28514442
OSBL8_HUMAN	OSBPL8	physical	28514442
AT133_HUMAN	ATP13A3	physical	28514442
SPPL3_HUMAN	SPPL3	physical	28514442
S12A9_HUMAN	SLC12A9	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442
NPC1_HUMAN	NPC1	physical	28514442
RETST_HUMAN	RETSAT	physical	28514442
CJ035_HUMAN	C10orf35	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.