dbPTM

TM143_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TM143_HUMAN
UniProt AC	Q96AN5
Protein Name	Transmembrane protein 143
Gene Name	TMEM143
Organism	Homo sapiens (Human).
Sequence Length	459
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MTVELWLRLRGKGLAMLHVTRGVWGSRVRVWPLLPALLGPPRALSSLAAKMGEYRKMWNPREPRDWAQQYRERFIPFSKEQLLRLLIQEFHSSPAEKAALEAFSAHVDFCTLFHYHQILARLQALYDPINPDRETLDQPSLTDPQRLSNEQEVLRALEPLLAQANFSPLSEDTLAYALVVHHPQDEVQVTVNLDQYVYIHFWALGQRVGQMPLKSSVGSRRGFFTKLPPAERRYFKRVVLAARTKRGHLVLKSFKDTPLEGLEQLLPELKVRTPTLQRALLNLMLVVSGVAIFVNVGMVVLTDLKVATSLLLLLFAIFMGLRASKMFGQRRSAQALELAHMLYYRSTSNNSELLSALALRAQDEHTKEALLAHSFLARRPGGTQGSPEETSRWLRSEVENWLLAKSGCEVTFNGTRALAHLQALTPSMGLYPPPGFPKLDPVAPITSEPPQATPSSNIS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	VTRGVWGSRVRVWPL ECCCCCCCCCCHHHC	16.34	30631047
215	Phosphorylation	VGQMPLKSSVGSRRG CCCCCCCCCCCCCCC	37.63	29759185
216	Phosphorylation	GQMPLKSSVGSRRGF CCCCCCCCCCCCCCC	28.98	29759185
253	Phosphorylation	RGHLVLKSFKDTPLE CCEEEECCCCCCCCH	33.11	24719451
332	Phosphorylation	KMFGQRRSAQALELA HHHCCHHHHHHHHHH	27.24	-
355	Phosphorylation	SNNSELLSALALRAQ CCHHHHHHHHHHHHC	33.58	23403867
374	Phosphorylation	KEALLAHSFLARRPG HHHHHHHHHHHCCCC	19.15	24719451
386	Phosphorylation	RPGGTQGSPEETSRW CCCCCCCCHHHHHHH	21.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TM143_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TM143_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TM143_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TM143_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TM143_HUMAN

Related Literatures of Post-Translational Modification