SPIT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPIT1_HUMAN
• UniProt AC: O43278
• Protein Name: Kunitz-type protease inhibitor 1
• Gene Name: SPINT1
• Organism: Homo sapiens (Human).
• Sequence Length: 529
• Subcellular Localization: Secreted.
• Protein Description: Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14)..
• Protein Sequence: MAPARTMARARLAPAGIPAVALWLLCTLGLQGTQAGPPPAPPGLPAGADCLNSFTAGVPGFVLDTNASVSNGATFLESPTVRRGWDCVRACCTTQNCNLALVELQPDRGEDAIAACFLINCLYEQNFVCKFAPREGFINYLTREVYRSYRQLRTQGFGGSGIPKAWAGIDLKVQPQEPLVLKDVENTDWRLLRGDTDVRVERKDPNQVELWGLKEGTYLFQLTVTSSDHPEDTANVTVTVLSTKQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGVQGGPLRGSSGAQATFPQGPSMERRHPVCSGTCQPTQFRCSNGCCIDSFLECDDTPNCPDASDEAACEKYTSGFDELQRIHFPSDKGHCVDLPDTGLCKESIPRWYYNPFSEHCARFTYGGCYGNKNNFEEEQQCLESCRGISKKDVFGLRREIPIPSTGSVEMAVAVFLVICIVVVVAILGYCFFKNQRKDFHGHHHHPPPTPASSTVSTTEDTEHLVYNHTTRPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	N-linked_Glycosylation	PGFVLDTNASVSNGA CCEEEECCCCCCCCC	29.86	UniProtKB CARBOHYD
154	Phosphorylation	RSYRQLRTQGFGGSG HHHHHHHHCCCCCCC	41.45	22210691
160	Phosphorylation	RTQGFGGSGIPKAWA HHCCCCCCCCCCCCC	33.65	24719451
172 (in isoform 2)	Ubiquitination	-	34.77	21906983
172 (in isoform 1)	Ubiquitination	-	34.77	21906983
172	Ubiquitination	AWAGIDLKVQPQEPL CCCCCCCEECCCCCE	34.77	22817900
235	N-linked_Glycosylation	DHPEDTANVTVTVLS CCCCCCCEEEEEEEE	31.89	UniProtKB CARBOHYD
277	Phosphorylation	PTEQICKSFVYGGCL CHHHHHHHHHHHCCC	18.61	18669648
311	Phosphorylation	QGGPLRGSSGAQATF CCCCCCCCCCCCCCC	21.11	22210691
312	Phosphorylation	GGPLRGSSGAQATFP CCCCCCCCCCCCCCC	40.76	22210691
317	O-linked_Glycosylation	GSSGAQATFPQGPSM CCCCCCCCCCCCCCC	24.62	OGP
334	O-linked_Glycosylation	RHPVCSGTCQPTQFR CCCCCCCCCCCCEEE	7.53	OGP
373	O-linked_Glycosylation	EAACEKYTSGFDELQ HHHHHHHHCCCHHHH	33.18	OGP
403	Phosphorylation	DTGLCKESIPRWYYN CCCCCCCCCCHHHCC	24.32	24719451
505	Phosphorylation	HHHHPPPTPASSTVS CCCCCCCCCCCCCCC	36.94	-
508	Phosphorylation	HPPPTPASSTVSTTE CCCCCCCCCCCCCCC	27.96	-
510	Phosphorylation	PPTPASSTVSTTEDT CCCCCCCCCCCCCCC	18.91	-
512	Phosphorylation	TPASSTVSTTEDTEH CCCCCCCCCCCCCCE	29.69	-
514	Phosphorylation	ASSTVSTTEDTEHLV CCCCCCCCCCCCEEE	25.10	-
522	Phosphorylation	EDTEHLVYNHTTRPL CCCCEEEECCCCCCC	13.95	27259358
523	N-linked_Glycosylation	DTEHLVYNHTTRPL- CCCEEEECCCCCCC-	20.67	UniProtKB CARBOHYD
526	Phosphorylation	HLVYNHTTRPL---- EEEECCCCCCC----	23.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPIT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPIT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPIT1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPIT1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.