NRX3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NRX3B_HUMAN
• UniProt AC: Q9HDB5
• Protein Name: Neurexin-3-beta
• Gene Name: NRXN3
• Organism: Homo sapiens (Human).
• Sequence Length: 637
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Description: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May play a role in angiogenesis (By similarity)..
• Protein Sequence: MHLRIHARRSPPRRPAWTLGIWFLFWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 4)	Phosphorylation	-	33.43	17081983
10 (in isoform 2)	Phosphorylation	-	33.43	17081983
10	Phosphorylation	LRIHARRSPPRRPAW CEEECCCCCCCCHHH	33.43	17081983
10 (in isoform 3)	Phosphorylation	-	33.43	17081983
74	Phosphorylation	VPISIYRSPVSLRGG CEEEEEECCCEECCC	16.81	19369195
74 (in isoform 4)	Phosphorylation	-	16.81	19369195
74 (in isoform 2)	Phosphorylation	-	16.81	19369195
74 (in isoform 3)	Phosphorylation	-	16.81	19369195
184	N-linked_Glycosylation	RFTRNGGNATLQVDN EEEECCCCEEEEECC	31.02	UniProtKB CARBOHYD
252	N-linked_Glycosylation	NNPNIKINGSVRLVG CCCCCEECCEEEEEE	31.52	UniProtKB CARBOHYD
296	N-linked_Glycosylation	ATTTTRKNRSTASIQ EEECCCCCCCCCEEC	39.58	UniProtKB CARBOHYD
328 (in isoform 2)	Phosphorylation	-	19.86	-
329 (in isoform 2)	Phosphorylation	-	60.98	-
346	Phosphorylation	VEDPLATPPIATRAP ECCCCCCCCCCCCCC	16.82	24719451
352	Phosphorylation	TPPIATRAPSITLPP CCCCCCCCCCCCCCC	9.61	24719451
466	O-linked_Glycosylation	KVSETSRTTTTSLSP CCCCCCCCCCCCCCH	28.41	OGP
479	O-linked_Glycosylation	SPELIRFTASSSSGM CHHHHEEEECCCCCC	18.77	OGP
481	O-linked_Glycosylation	ELIRFTASSSSGMVP HHHEEEECCCCCCCC	27.91	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NRX3B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NRX3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NRX3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NLGN1_HUMAN	NLGN1	physical	8576240
NLGN2_HUMAN	NLGN2	physical	8576240
NLGN3_HUMAN	NLGN3	physical	8576240

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND MASSSPECTROMETRY.
PubMed: 19369195

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.
PubMed: 17081983