FAIM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAIM1_HUMAN
• UniProt AC: Q9NVQ4
• Protein Name: Fas apoptotic inhibitory molecule 1
• Gene Name: FAIM
• Organism: Homo sapiens (Human).
• Sequence Length: 179
• Subcellular Localization: Cytoplasm.
• Protein Description: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells..
• Protein Sequence: MTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTDLVAVWD ------CCCEEEEEE	37.73	19413330
3 (in isoform 3)	Phosphorylation	-	37.54	25921289
7 (in isoform 3)	Phosphorylation	-	3.32	25921289
13	Phosphorylation	AVWDVALSDGVHKIE EEEEEECCCCCEEEE	23.68	29083192
15 (in isoform 3)	Phosphorylation	-	21.76	27251275
24	Acetylation	HKIEFEHGTTSGKRV EEEEEECCCCCCCEE	24.40	19413330
25	Phosphorylation	KIEFEHGTTSGKRVV EEEEECCCCCCCEEE	21.50	25954137
26	Phosphorylation	IEFEHGTTSGKRVVY EEEECCCCCCCEEEE	39.82	25954137
27	Phosphorylation	EFEHGTTSGKRVVYV EEECCCCCCCEEEEE	42.00	25954137
29	Ubiquitination	EHGTTSGKRVVYVDG ECCCCCCCEEEEECC	41.61	29967540
36	Acetylation	KRVVYVDGKEEIRKE CEEEEECCCHHHHHH	29.27	19413330
37	Ubiquitination	RVVYVDGKEEIRKEW EEEEECCCHHHHHHH	47.94	29967540
42	Ubiquitination	DGKEEIRKEWMFKLV CCCHHHHHHHHHHHH	62.48	22817900
47	Ubiquitination	IRKEWMFKLVGKETF HHHHHHHHHHCCEEE	26.59	22817900
47 (in isoform 1)	Ubiquitination	-	26.59	21890473
51	Ubiquitination	WMFKLVGKETFYVGA HHHHHHCCEEEEEEE	46.21	22817900
53	O-linked_Glycosylation	FKLVGKETFYVGAAK HHHHCCEEEEEEEEC	24.61	30379171
55	Phosphorylation	LVGKETFYVGAAKTK HHCCEEEEEEEECCE	12.85	29496907
59	Ubiquitination	ETFYVGAAKTKATIN EEEEEEEECCEEEEE	17.70	29967540
60	Ubiquitination	TFYVGAAKTKATINI EEEEEEECCEEEEEE	50.45	32015554
62	Ubiquitination	YVGAAKTKATINIDA EEEEECCEEEEEECE	42.71	25015289
63	Ubiquitination	VGAAKTKATINIDAI EEEECCEEEEEECEE	20.95	29967540
64	Ubiquitination	GAAKTKATINIDAIS EEECCEEEEEECEEC	18.99	22817900
69 (in isoform 3)	Ubiquitination	-	8.27	21890473
69	Ubiquitination	KATINIDAISGFAYE EEEEEECEECCEEEE	8.27	21890473
71	Ubiquitination	TINIDAISGFAYEYT EEEECEECCEEEEEE	29.58	29967540
73	Ubiquitination	NIDAISGFAYEYTLE EECEECCEEEEEEEE	5.37	22817900
76	Ubiquitination	AISGFAYEYTLEING EECCEEEEEEEEECC	28.72	22817900
81 (in isoform 2)	Ubiquitination	-	10.41	21890473
81	Ubiquitination	AYEYTLEINGKSLKK EEEEEEEECCEEHHH	10.41	21890473
82	Ubiquitination	YEYTLEINGKSLKKY EEEEEEECCEEHHHH	42.33	32015554
84	Ubiquitination	YTLEINGKSLKKYME EEEEECCEEHHHHHH	48.39	25015289
85	Ubiquitination	TLEINGKSLKKYMED EEEECCEEHHHHHHH	46.98	22817900
94	Ubiquitination	KKYMEDRSKTTNTWV HHHHHHCCCCCCEEE	46.83	32015554
96	Ubiquitination	YMEDRSKTTNTWVLH HHHHCCCCCCEEEEE	26.90	22817900
101	Ubiquitination	SKTTNTWVLHMDGEN CCCCCEEEEEECCCC	2.18	21890473
105	Ubiquitination	NTWVLHMDGENFRIV CEEEEEECCCCEEEE	50.97	22817900
114	Ubiquitination	ENFRIVLEKDAMDVW CCEEEEEECCCEEEE	37.69	25015289
116	Ubiquitination	FRIVLEKDAMDVWCN EEEEEECCCEEEEEC	37.44	25015289
125	Ubiquitination	MDVWCNGKKLETAGE EEEEECCEEEEECEE	39.95	32015554
147	Ubiquitination	THFSIGNHDCYIKAV EEEEECCCCEEEEEE	22.70	32015554
158	Ubiquitination	IKAVSSGKRKEGIIH EEEECCCCCCCCEEE	63.34	22817900
159	Ubiquitination	KAVSSGKRKEGIIHT EEECCCCCCCCEEEE	45.87	32015554
160 (in isoform 1)	Ubiquitination	-	64.87	21890473
160	Ubiquitination	AVSSGKRKEGIIHTL EECCCCCCCCEEEEE	64.87	22817900
180	Ubiquitination	EIPEIAS-------- CCCCCCC--------		22817900
182	Ubiquitination	PEIAS---------- CCCCC----------		21890473
182 (in isoform 3)	Ubiquitination	-		21890473
192	Ubiquitination	-------------------- --------------------		22817900
194 (in isoform 2)	Ubiquitination	-		21890473
194	Ubiquitination	---------------------- ----------------------		21890473
212	Ubiquitination	---------------------------------------- ----------------------------------------		22817900
214	Ubiquitination	------------------------------------------ ------------------------------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAIM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAIM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAIM1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FAIM1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.