UBE3D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE3D_HUMAN
• UniProt AC: Q7Z6J8
• Protein Name: E3 ubiquitin-protein ligase E3D
• Gene Name: UBE3D
• Organism: Homo sapiens (Human).
• Sequence Length: 389
• Subcellular Localization: Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome..
• Protein Sequence: MAASAAETRVFLEVRGQLQSALLILGEPKEGGMPMNISIMPSSLQMKTPEGCTEIQLPAEVRLVPSSCRGLQFVVGDGLHLRLQTQAKLGTKLISMFNQSSQTQECCTFYCQSCGEVIIKDRKLLRVLPLPSENWGALVGEWCCHPDPFANKSLHPQENDCFIGDSFFLVNLRTSLWQQRPELSPVEMCCVSSDNHCKLEPKANTKVICKRCKVMLGETVSSETTKFYMTEIIIQSSERSFPIIPRSWFVQSVIAQCLVQLSSARSTFRFTIQGQDDKVYILLWLLNSDSLVIESLRNSKYIKKFPLLENTFKADSSSAWSAVKVLYQPCIKSRNEKLVSLWESDISVHPLTLPSATCLELLLILSKSNANLPSSLRRVNSFQVAFLKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASAAETR ------CCCCHHHHH	15.32	22814378
4	Phosphorylation	----MAASAAETRVF ----CCCCHHHHHHH	20.62	22210691
20	Phosphorylation	EVRGQLQSALLILGE HHHHHHHEEEECCCC	29.49	22210691
38	Phosphorylation	GGMPMNISIMPSSLQ CCCCCEEEECCCCCC	14.08	22210691
43	Phosphorylation	NISIMPSSLQMKTPE EEEECCCCCCCCCCC	19.42	22210691
88	Ubiquitination	LRLQTQAKLGTKLIS EEEHHHHHHHHHHHH	37.32	-
174	Phosphorylation	FFLVNLRTSLWQQRP EEEEECCHHHHHHCC	31.19	29449344
175	Phosphorylation	FLVNLRTSLWQQRPE EEEECCHHHHHHCCC	22.60	29449344
184	Phosphorylation	WQQRPELSPVEMCCV HHHCCCCCCCEEEEE	25.82	25159151
228	Phosphorylation	SSETTKFYMTEIIIQ CCCCCCEEEEEEEEE	12.51	28509920
230	Phosphorylation	ETTKFYMTEIIIQSS CCCCEEEEEEEEECC	16.80	28509920
347	Phosphorylation	SLWESDISVHPLTLP HHHHCCCCCCCCCCC	21.26	22210691
352	Phosphorylation	DISVHPLTLPSATCL CCCCCCCCCCHHHHH	40.86	22210691
357	Phosphorylation	PLTLPSATCLELLLI CCCCCHHHHHHHHHH	23.20	22210691
374	Phosphorylation	KSNANLPSSLRRVNS HCCCCCCHHHHHCCE	45.21	-
381	Phosphorylation	SSLRRVNSFQVAFLK HHHHHCCEEEEEEEC	17.75	27732954

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE3D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE3D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE3D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE2C_HUMAN	UBE2C	physical	15749827
UBE3D_HUMAN	UBE3D	physical	15749827
CCNB1_HUMAN	CCNB1	physical	15749827
KTU_HUMAN	DNAAF2	physical	28514442
GTPB2_HUMAN	GTPBP2	physical	28514442
SUFU_HUMAN	SUFU	physical	28514442
STIP1_HUMAN	STIP1	physical	28514442
BORA_HUMAN	BORA	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
PPM1A_HUMAN	PPM1A	physical	28514442
CPSF3_HUMAN	CPSF3	physical	28514442
T22D3_HUMAN	TSC22D3	physical	28514442
KTU_HUMAN	DNAAF2	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.