| UniProt ID | ZY11A_HUMAN | |
|---|---|---|
| UniProt AC | Q6WRX3 | |
| Protein Name | Protein zyg-11 homolog A | |
| Gene Name | ZYG11A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 759 | |
| Subcellular Localization | ||
| Protein Description | Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC.. | |
| Protein Sequence | MVHFLHPGHTPRNIVPPDAQKDALGCCVVQEEASPYTLVNICLNVLIANLEKLCSERPDGTLCLPEHWSFPQEVAERFLRVMTWQGKLTDRTASIFRGNQMKLKLVNIQKAKISTAAFIKAFCRHKLIELNATAVHADLPVPDIISGLCSNRWIQQNLQCLLLDSTSIPQNSRLLFFSQLTGLRILSVFNVCFHTEDLANVSQLPRLESLDISNTLVTDISALLTCKDRLKSLTMHYLKCLAMTKSQILAVIRELKCLLHLDISDHRQLKSDLAFHLLQQKDILPNVVSLDISGGNCITDEAVELFIRLRPAMQFVGLLATDAGSSDFFTTKQGLRVAGGASMSQISEALSRYRNRSCFVKEALHRLFTETFSMEVTMPAILKLVAIGMRNHPLDLRVQFTASACALNLTRQGLAKGMPVRLLSEVTCLLFKALKNFPHYQQLQKNCLLSLTNSRILVDVPFDRFDAAKFVMRWLCKHENPKMQTMAVSVTSILALQLSPEQTAQLEELFMAVKELLAIVKQKTTENLDDVTFLFTLKALWNLTDGSPAACKHFIENQGLQIFIQVLETFSESAIQSKVLGLLNNIAEVRELSSKLVTEDVLKHINSLLCSREMEVSYFAAGIIAHLTSDRQLWISRDFQRRTLLQDLHATIQNWPSSSCKMTALVTYRSFKTFFPLLGNFSQPEVQLWALWAMYHVCSKNPSKYCKMLVEEEGLQLLCDIQEHSEATPKAQQIAASILDDFRMHFMNYQRPTLCQMPF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 92 | Phosphorylation | QGKLTDRTASIFRGN CCCCCCCCHHHHCCC | 27.80 | - | |
| 93 | Ubiquitination | GKLTDRTASIFRGNQ CCCCCCCHHHHCCCC | 11.09 | 29967540 | |
| 110 | Ubiquitination | LKLVNIQKAKISTAA EEEEEEEHHHHHHHH | 48.10 | 29967540 | |
| 114 | Phosphorylation | NIQKAKISTAAFIKA EEEHHHHHHHHHHHH | 15.99 | - | |
| 127 (in isoform 2) | Ubiquitination | - | 2.76 | 21890473 | |
| 127 | Ubiquitination | KAFCRHKLIELNATA HHHHHCCCHHCCCCE | 2.76 | 21890473 | |
| 181 | Phosphorylation | LLFFSQLTGLRILSV EEHHHHHHCHHHHHH | 26.91 | 24719451 | |
| 225 | Phosphorylation | TDISALLTCKDRLKS HHHHHHHHCHHHHHH | 20.54 | 26074081 | |
| 232 | Phosphorylation | TCKDRLKSLTMHYLK HCHHHHHHHHHHHHH | 33.39 | 26074081 | |
| 234 | Phosphorylation | KDRLKSLTMHYLKCL HHHHHHHHHHHHHHH | 14.70 | 26074081 | |
| 237 | Phosphorylation | LKSLTMHYLKCLAMT HHHHHHHHHHHHHCC | 9.31 | 26074081 | |
| 253 | Ubiquitination | SQILAVIRELKCLLH HHHHHHHHHHHHHHC | 36.27 | 29967540 | |
| 271 | Phosphorylation | SDHRQLKSDLAFHLL CCCHHHHHHHHHHHH | 46.58 | - | |
| 332 | Ubiquitination | SSDFFTTKQGLRVAG CCCCEECCCCCEECC | 39.03 | 21963094 | |
| 344 | Phosphorylation | VAGGASMSQISEALS ECCCCCHHHHHHHHH | 23.13 | 27174698 | |
| 347 | Phosphorylation | GASMSQISEALSRYR CCCHHHHHHHHHHHH | 14.80 | 27174698 | |
| 351 | Phosphorylation | SQISEALSRYRNRSC HHHHHHHHHHHCCCH | 34.02 | 27174698 | |
| 351 | O-linked_Glycosylation | SQISEALSRYRNRSC HHHHHHHHHHHCCCH | 34.02 | 30379171 | |
| 353 | Phosphorylation | ISEALSRYRNRSCFV HHHHHHHHHCCCHHH | 14.63 | 27174698 | |
| 371 | Phosphorylation | LHRLFTETFSMEVTM HHHHHHHCCCCCCHH | 20.25 | - | |
| 373 | Phosphorylation | RLFTETFSMEVTMPA HHHHHCCCCCCHHHH | 22.81 | - | |
| 410 | Ubiquitination | SACALNLTRQGLAKG HHHHHHHHHHHHHCC | 21.63 | 21890473 | |
| 424 | Phosphorylation | GMPVRLLSEVTCLLF CCCHHHHHHHHHHHH | 34.31 | - | |
| 427 | Phosphorylation | VRLLSEVTCLLFKAL HHHHHHHHHHHHHHH | 8.06 | - | |
| 435 | Ubiquitination | CLLFKALKNFPHYQQ HHHHHHHCCCCHHHH | 62.49 | 29967540 | |
| 450 | Phosphorylation | LQKNCLLSLTNSRIL HHHHCHHHHCCCCEE | 21.87 | - | |
| 469 | Ubiquitination | FDRFDAAKFVMRWLC CCHHHHHHHHHHHHH | 39.96 | 21890473 | |
| 469 (in isoform 1) | Ubiquitination | - | 39.96 | 21890473 | |
| 595 | Ubiquitination | EVRELSSKLVTEDVL HHHHHHHHHCHHHHH | 43.53 | 29967540 | |
| 636 | Phosphorylation | SDRQLWISRDFQRRT CCCCEEECHHHHHHH | 17.76 | 29978859 | |
| 667 | Phosphorylation | CKMTALVTYRSFKTF CCCEEEEEHHHHHHH | 17.67 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ZY11A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ZY11A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ZY11A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ZY11A_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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