| UniProt ID | TRDMT_HUMAN | |
|---|---|---|
| UniProt AC | O14717 | |
| Protein Name | tRNA (cytosine(38)-C(5))-methyltransferase | |
| Gene Name | TRDMT1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 391 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).. | |
| Protein Sequence | MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 96 | Phosphorylation | GDMTDSRTNSFLHIL CCCCCCCHHHHHHHH | 38.88 | 21949786 | |
| 98 | Phosphorylation | MTDSRTNSFLHILDI CCCCCHHHHHHHHHH | 28.68 | 21949786 | |
| 122 | Ubiquitination | YILLENVKGFEVSST EEEEECCCCCCEECH | 70.26 | - | |
| 153 | Phosphorylation | EFLLSPTSLGIPNSR EHHCCCCCCCCCCHH | 28.16 | - | |
| 204 | Ubiquitination | YAMDVENKIQEKNVE CCCCHHHHHHHCCCC | 32.06 | - | |
| 215 | Phosphorylation | KNVEPNISFDGSIQC CCCCCCCEECCCEEE | 24.75 | 28555341 | |
| 219 | Phosphorylation | PNISFDGSIQCSGKD CCCEECCCEEECCCC | 16.01 | 27690223 | |
| 261 | Phosphorylation | KDFLEDDTDVNQYLL HHHHHCCCCCHHHCC | 54.92 | 29083192 | |
| 266 | Phosphorylation | DDTDVNQYLLPPKSL CCCCCHHHCCCHHHH | 12.66 | 29083192 | |
| 272 | Phosphorylation | QYLLPPKSLLRYALL HHCCCHHHHHHHHHH | 38.11 | 24719451 | |
| 276 | Phosphorylation | PPKSLLRYALLLDIV CHHHHHHHHHHHHHH | 11.11 | 22210691 | |
| 286 | Phosphorylation | LLDIVQPTCRRSVCF HHHHHCHHCCCCCEE | 11.10 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TRDMT_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRDMT_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRDMT_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CSN6_HUMAN | COPS6 | physical | 16169070 | |
| RBM48_HUMAN | RBM48 | physical | 16169070 | |
| UT14A_HUMAN | UTP14A | physical | 16169070 | |
| STX1A_HUMAN | STX1A | physical | 16169070 | |
| EF1A1_HUMAN | EEF1A1 | physical | 16169070 | |
| LRIF1_HUMAN | LRIF1 | physical | 16169070 | |
| SETB1_HUMAN | SETDB1 | physical | 16169070 | |
| U119A_HUMAN | UNC119 | physical | 16169070 | |
| A4_HUMAN | APP | physical | 21832049 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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