TMCO4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TMCO4_HUMAN
• UniProt AC: Q5TGY1
• Protein Name: Transmembrane and coiled-coil domain-containing protein 4
• Gene Name: TMCO4
• Organism: Homo sapiens (Human).
• Sequence Length: 634
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MAMWNRPCQRLPQQPLVAEPTAEGEPHLPTGRELTEANRFAYAALCGISLSQLFPEPEHSSFCTEFMAGLVQWLELSEAVLPTMTAFASGLGGEGADVFVQILLKDPILKDDPTVITQDLLSFSLKDGHYDARARVLVCHMTSLLQVPLEELDVLEEMFLESLKEIKEEESEMAEASRKKKENRRKWKRYLLIGLATVGGGTVIGVTGGLAAPLVAAGAATIIGSAGAAALGSAAGIAIMTSLFGAAGAGLTGYKMKKRVGAIEEFTFLPLTEGRQLHITIAVTGWLASGKYRTFSAPWAALAHSREQYCLAWEAKYLMELGNALETILSGLANMVAQEALKYTVLSGIVAALTWPASLLSVANVIDNPWGVCLHRSAEVGKHLAHILLSRQQGRRPVTLIGFSLGARVIYFCLQEMAQEKDCQGIIEDVILLGAPVEGEAKHWEPFRKVVSGRIINGYCRGDWLLSFVYRTSSVQLRVAGLQPVLLQDRRVENVDLTSVVSGHLDYAKQMDAILKAVGIRTKPGWDEKGLLLAPGCLPSEEPRQAAAAASSGETPHQVGQTQGPISGDTSKLAMSTDPSQAQVPVGLDQSEGASLPAAASPERPPICSHGMDPNPLGCPDCACKTQGPSTGLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
114	Phosphorylation	PILKDDPTVITQDLL CCCCCCCCEEEHHHH	31.38	-
122	Phosphorylation	VITQDLLSFSLKDGH EEEHHHHHCCCCCCC	21.78	21815630
124	Phosphorylation	TQDLLSFSLKDGHYD EHHHHHCCCCCCCCH	31.00	22167270
242	Phosphorylation	AGIAIMTSLFGAAGA HHHHHHHHHHCHHCC	12.34	-
252	Phosphorylation	GAAGAGLTGYKMKKR CHHCCCCCCHHHHCC	37.23	-
254	Phosphorylation	AGAGLTGYKMKKRVG HCCCCCCHHHHCCCC	11.59	-
289	Phosphorylation	AVTGWLASGKYRTFS EEECCHHCCCEECCC	33.38	24719451
442	Ubiquitination	APVEGEAKHWEPFRK CCCCCCCCCCCCCHH	44.97	29967540
523	Ubiquitination	KAVGIRTKPGWDEKG HHHCCCCCCCCCCCC	31.52	29967540
529	Ubiquitination	TKPGWDEKGLLLAPG CCCCCCCCCEEECCC	53.00	29967540
551	Phosphorylation	RQAAAAASSGETPHQ HHHHHHHHCCCCCCC	33.86	28555341
552	Phosphorylation	QAAAAASSGETPHQV HHHHHHHCCCCCCCC	35.60	21712546
555	Phosphorylation	AAASSGETPHQVGQT HHHHCCCCCCCCCCC	29.60	25627689
567	Phosphorylation	GQTQGPISGDTSKLA CCCCCCCCCCCCCEE	33.48	28555341
570	Phosphorylation	QGPISGDTSKLAMST CCCCCCCCCCEEECC	31.14	28555341
591	Phosphorylation	VPVGLDQSEGASLPA CCCCCCCCCCCCCCC	37.35	28348404
595	Phosphorylation	LDQSEGASLPAAASP CCCCCCCCCCCCCCC	45.82	28348404
601	Phosphorylation	ASLPAAASPERPPIC CCCCCCCCCCCCCCC	23.67	28348404
609	Phosphorylation	PERPPICSHGMDPNP CCCCCCCCCCCCCCC	24.64	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TMCO4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TMCO4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TMCO4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TMCO4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.