CL066_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CL066_HUMAN
• UniProt AC: Q96MD2
• Protein Name: KICSTOR complex protein C12orf66 {ECO:0000305|PubMed:28199306}
• Gene Name: C12orf66 {ECO:0000312|HGNC:HGNC:26517}
• Organism: Homo sapiens (Human).
• Sequence Length: 445
• Subcellular Localization: Lysosome membrane .
• Protein Description: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose..
• Protein Sequence: MGESIPLAAPVPVEQAVLETFFSHLGIFSYDKAKDNVEKEREANKSAGGSWLSLLAALAHLAAAEKVYHSLTYLGQKLGGQSFFSRKDSIRTIYTSLHNELKKVVTGRGALGGTAPHVEELLSHLSEQLCFFVQARMEMADFYEKMYTLSTQKFINAEELVGLLDAIMKKYSSRFHHPILSPLESSFQLEVDVLCHLLKAQAQVSEWKFLPSLVNLHSAHTKLQTWGQIFEKQRETKKHLFGGQSQKAVQPPHLFLWLMKLKNMLLAKFSFYFHEALSRQTTASEMKTLTAKANPDFFGKISSFIRKYDAANVSLIFDNRGSESFQGHGYHHPHSYREAPKGVDQYPAVVSLPSDRPVMHWPNVIMIMTDRTSDLNSLEKVVHFYDDKVQSTYFLTRPEPHFTIVIIFESKKSERDSHFISFLNEVSLALKNPKVFASLKPGAKG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
53	Phosphorylation	SAGGSWLSLLAALAH HCCHHHHHHHHHHHH	18.32	20058876
82	Phosphorylation	GQKLGGQSFFSRKDS HHHHCCCCCCCCHHH	31.37	28857561
171	Phosphorylation	LDAIMKKYSSRFHHP HHHHHHHHHHCCCCC	13.32	22496350
238	Ubiquitination	EKQRETKKHLFGGQS HHHHHHHCHHHCCCC	53.62	29967540
300	Ubiquitination	ANPDFFGKISSFIRK CCCCHHHHHHHHHHH	33.97	-
303	Phosphorylation	DFFGKISSFIRKYDA CHHHHHHHHHHHHCC	28.32	24719451
307	Ubiquitination	KISSFIRKYDAANVS HHHHHHHHHCCCCEE	42.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CL066_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CL066_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CL066_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CL066_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.