NPRL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NPRL3_HUMAN
• UniProt AC: Q12980
• Protein Name: GATOR complex protein NPRL3 {ECO:0000305}
• Gene Name: NPRL3 {ECO:0000312|HGNC:HGNC:14124}
• Organism: Homo sapiens (Human).
• Sequence Length: 569
• Subcellular Localization: Lysosome membrane . Localization to lysosomes is amino acid-independent.
• Protein Description: As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway..
• Protein Sequence: MRDNTSPISVILVSSGSRGNKLLFRYPFQRSQEHPASQTSKPRSRYAASNTGDHADEQDGDSRFSDVILATILATKSEMCGQKFELKIDNVRFVGHPTLLQHALGQISKTDPSPKREAPTMILFNVVFALRANADPSVINCLHNLSRRIATVLQHEERRCQYLTREAKLILALQDEVSAMADGNEGPQSPFHHILPKCKLARDLKEAYDSLCTSGVVRLHINSWLEVSFCLPHKIHYAASSLIPPEAIERSLKAIRPYHALLLLSDEKSLLGELPIDCSPALVRVIKTTSAVKNLQQLAQDADLALLQVFQLAAHLVYWGKAIIIYPLCENNVYMLSPNASVCLYSPLAEQFSHQFPSHDLPSVLAKFSLPVSLSEFRNPLAPAVQETQLIQMVVWMLQRRLLIQLHTYVCLMASPSEEEPRPREDDVPFTARVGGRSLSTPNALSFGSPTSSDDMTLTSPSMDNSSAELLPSGDSPLNQRMTENLLASLSEHERAAILSVPAAQNPEDLRMFARLLHYFRGRHHLEEIMYNENTRRSQLLMLFDKFRSVLVVTTHEDPVIAVFQALLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRDNTSPISVIL ---CCCCCCCEEEEE	39.92	25072903
6	Phosphorylation	--MRDNTSPISVILV --CCCCCCCEEEEEE	26.87	25072903
9	Phosphorylation	RDNTSPISVILVSSG CCCCCCEEEEEEECC	13.39	25072903
14	Phosphorylation	PISVILVSSGSRGNK CEEEEEEECCCCCCE	26.07	25072903
15	Phosphorylation	ISVILVSSGSRGNKL EEEEEEECCCCCCEE	33.05	25072903
17	Phosphorylation	VILVSSGSRGNKLLF EEEEECCCCCCEEEE	38.67	25072903
21	Ubiquitination	SSGSRGNKLLFRYPF ECCCCCCEEEEEECC	49.76	-
41	Ubiquitination	HPASQTSKPRSRYAA CCCCCCCCCCHHHCC	48.08	21906983
51	Phosphorylation	SRYAASNTGDHADEQ HHHCCCCCCCCCCCC	41.30	-
62	Phosphorylation	ADEQDGDSRFSDVIL CCCCCCCCCHHHHHH	40.53	-
76	Ubiquitination	LATILATKSEMCGQK HHHHHHHCHHHCCCC	38.52	-
83	Ubiquitination	KSEMCGQKFELKIDN CHHHCCCCEEEEECC	26.53	-
87	Malonylation	CGQKFELKIDNVRFV CCCCEEEEECCEEEC	40.59	26320211
87	Ubiquitination	CGQKFELKIDNVRFV CCCCEEEEECCEEEC	40.59	-
87	Acetylation	CGQKFELKIDNVRFV CCCCEEEEECCEEEC	40.59	25953088
109	Ubiquitination	HALGQISKTDPSPKR HHHHCCCCCCCCCCC	59.58	-
120	Phosphorylation	SPKREAPTMILFNVV CCCCCCCCEEEEHHH	24.72	24719451
178	Phosphorylation	LALQDEVSAMADGNE HHHHHHHHHHCCCCC	15.41	28176443
189	Phosphorylation	DGNEGPQSPFHHILP CCCCCCCCCCHHHHH	32.44	20873877
205	Ubiquitination	CKLARDLKEAYDSLC CHHHHHHHHHHHHHH	44.58	-
208	Phosphorylation	ARDLKEAYDSLCTSG HHHHHHHHHHHHCCC	13.73	20068231
210	Phosphorylation	DLKEAYDSLCTSGVV HHHHHHHHHHCCCCE	16.81	29978859
213	Phosphorylation	EAYDSLCTSGVVRLH HHHHHHHCCCCEEEE	33.53	29978859
214	Phosphorylation	AYDSLCTSGVVRLHI HHHHHHCCCCEEEEE	28.70	24850871
237	Phosphorylation	CLPHKIHYAASSLIP ECCHHHHHHHHHCCC	13.82	23898821
240	Phosphorylation	HKIHYAASSLIPPEA HHHHHHHHHCCCHHH	19.94	23898821
241	Phosphorylation	KIHYAASSLIPPEAI HHHHHHHHCCCHHHH	26.12	23898821
253	Ubiquitination	EAIERSLKAIRPYHA HHHHHHHHHHHHHHH	42.91	-
258	Phosphorylation	SLKAIRPYHALLLLS HHHHHHHHHHEEEEC	7.00	20049867
287	Ubiquitination	PALVRVIKTTSAVKN HHHHHHHHHHHHHHH	42.78	-
353	Phosphorylation	SPLAEQFSHQFPSHD CHHHHHHHCCCCCCC	18.97	25332170
431	Phosphorylation	REDDVPFTARVGGRS CCCCCCCEEEECCCC	13.90	26074081
438	Phosphorylation	TARVGGRSLSTPNAL EEEECCCCCCCCCCC	29.91	26074081
440	Phosphorylation	RVGGRSLSTPNALSF EECCCCCCCCCCCCC	42.96	26074081
441	Phosphorylation	VGGRSLSTPNALSFG ECCCCCCCCCCCCCC	26.34	26074081
446	Phosphorylation	LSTPNALSFGSPTSS CCCCCCCCCCCCCCC	25.75	26074081
476	Phosphorylation	ELLPSGDSPLNQRMT CCCCCCCCHHHHHHH	34.51	26285051
538	Phosphorylation	YNENTRRSQLLMLFD CCCCCCHHHHHHHHH	23.14	29214152
546	Ubiquitination	QLLMLFDKFRSVLVV HHHHHHHHCCEEEEE	35.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NPRL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NPRL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NPRL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBP2_HUMAN	APPBP2	physical	25416956
DDX11_HUMAN	DDX11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.