CAST2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAST2_HUMAN
• UniProt AC: A6NHX0
• Protein Name: Cytosolic arginine sensor for mTORC1 subunit 2 {ECO:0000312|HGNC:HGNC:37073}
• Gene Name: CASTOR2 {ECO:0000303|PubMed:26972053, ECO:0000312|HGNC:HGNC:37073}
• Organism: Homo sapiens (Human).
• Sequence Length: 329
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2-containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway..
• Protein Sequence: MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADQNISVFMLSTYQTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLGITNGFVKPKLVQRPVIHPLSSPSNRFCVTSLDPDTLPAVATLLMDVMFYSNGVKDPMATGDDCGHIRFFSFSLIEGYISLVMDVQTQQRFPSNLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENINGVISALKVSQAEKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Acetylation	LFTYGLIKLAFLSSK HHHHHHHHHHHHCCC		11190477
36	Acetylation	KLAFLSSKTRCKFFS HHHHHCCCCCEEEEE		11190485
36	Ubiquitination	KLAFLSSKTRCKFFS HHHHHCCCCCEEEEE		-
167	Ubiquitination	GITNGFVKPKLVQRP CCCCCCCCCCEECCC		22817900
167	Ubiquitination	GITNGFVKPKLVQRP CCCCCCCCCCEECCC		21906983
169	Ubiquitination	TNGFVKPKLVQRPVI CCCCCCCCEECCCEE		22817900
322	Ubiquitination	NGVISALKVSQAEKH CHHHHHHHHHHHCCC		32015554

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAST2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAST2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAST2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MIO_HUMAN	MIOS	physical	26972053
CAST2_HUMAN	GATSL2	physical	26972053
CAST1_HUMAN	GATSL3	physical	26972053
WDR24_HUMAN	WDR24	physical	26972053

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.